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Composition and cataplasm for promoting transdermal absorption of evodiamine

A technology of evodiamine and poultice, which is applied in the field of compositions for promoting transdermal absorption of evodiamine, can solve problems such as difficulty in oral absorption, and achieve the effects of excellent penetration promoting effect, alleviating discomfort, and being beneficial to treatment or adjuvant treatment.

Inactive Publication Date: 2019-02-22
SOUTHWEST UNIVERSITY FOR NATIONALITIES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Evodiamine is a poorly soluble compound, almost insoluble in water and most organic solvents, difficult to absorb when taken orally

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1 composition of the present invention

[0033] Take 4 g of peppermint oil, 1 g of oleic acid, and 3 g of wintergreen oil, and mix them uniformly to obtain the composition of the present invention.

Embodiment 2

[0034] The preparation of embodiment 2 cataplasm of the present invention

[0035] Element:

[0036] Phase A: glycerin 13g, NP-8002g, aluminum glycolate 0.04g;

[0037] Phase B: 38g water, 4.5g gelatin, 0.05g tartaric acid;

[0038] Phase C: 0.1g evodiamine, 3g absolute ethanol, 6g 1% w / w carbomer gel;

[0039] Transdermal absorption enhancer 1.5g, absolute ethanol 1ml.

[0040] Preparation:

[0041] (1) Take glycerin and NP-800 and stir evenly, add aluminum glyoxate dissolved in 1g of water, stir well, and use it as phase A;

[0042] (2) Take water and gelatin, heat until dissolved, then add tartaric acid, stir well as phase B;

[0043] (3) Dissolve carbomer with water, fully swell, add triethanolamine to adjust to neutrality, and obtain 1% w / w carbomer gel; take evodiamine, add ethanol to dissolve and add carbomer gel as C Mutually;

[0044] (4) Mix phase A and phase B evenly, add phase C and stir evenly, then add a transdermal absorption accelerator (peppermint oil: ...

Embodiment 3

[0046] Example 3 Composition of the present invention promotes evodiamine transdermal absorption test

[0047] The test experiment of the present invention mainly refers to "In vitro transdermal absorption characteristics of oil-in-water microemulsion cataplasm of Evodia rutaecarpa. Zhang Guangchang, et al. Chinese Journal of Experimental Formulas, 2015, Volume 21, Issue 17".

[0048] (1) Preparation of isolated skin

[0049] Healthy nude mice were taken and killed by cervical dislocation. The abdominal skin was cut off with scissors and the fascia was gently scraped off with a blade, rinsed with normal saline for later use.

[0050] (2) Selection of receiving fluid for isolated skin Use 30% ethanol saline as the receiving fluid.

[0051] (3) Collection and determination of samples

[0052] Catapult of the present invention and contrast group Catapult A, B, C, D, E each 5 groups, the nude mouse skin that has been processed is fixed on the diffusion cell, and the volume of di...

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PUM

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Abstract

The invention provides a composition for promoting transdermal absorption of evodiamine. The composition consists of the following components in parts by weight: 3-5 parts of peppermint oil, 1-2 parts of oleic acid and 2-4 parts of wintergreen oil. The cataplasm disclosed by the invention takes the combination of the peppermint oil, the oleic acid and the wintergreen oil as a transdermal absorption enhancer; compared with the single use of borneol, the peppermint oil, the oleic acid or the wintergreen oil, the combined use can significantly increase a permeation amount of the evodiamine, showing that the skin permeability of the ingredient, namely the evodiamine, can be effectively promoted on the basis of a synergistic effect which is developed with the combined use of the peppermint oil, the oleic acid and the wintergreen oil.

Description

technical field [0001] The invention relates to a composition for promoting transdermal absorption of evodiamine. Background technique [0002] Evodia rutaecarpa has the functions of dispelling cold and relieving pain, lowering adverse flow and relieving vomiting, helping yang and relieving diarrhea. It is often used clinically to treat Jueyin headache, cold-damp beriberi, abdominal pain during menstruation, etc. It has the functions of protecting the heart, anti-arrhythmia, anti-inflammatory and analgesic. Its main functional components are evodiamine and evodiamine. Evodiamine is a poorly soluble compound, almost insoluble in water and most organic solvents, and difficult to absorb when taken orally. Systemic administration of evodiamine is not an ideal route of administration for exerting the analgesic effect of these compounds. Local application of drugs can directly reach the lesion, increase the local drug concentration, reduce the distribution of drugs in the system...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/44A61K47/12A61K9/70A61K31/519A61P29/00A61P19/06
CPCA61K9/7023A61K31/519A61K47/12A61K47/44
Inventor 顾健谭锐
Owner SOUTHWEST UNIVERSITY FOR NATIONALITIES