3-cyanopyridine production method

Abstract

The present invention discloses a 3-cyanopyridine production method, which belongs to the technical field of fine chemical production, raw material molar ratio is as follows: 3-methylpyridine:ammonia:oxygen:homemade catalyst is 1: 4-14: 12-40: 1.5-2.5; and key points of the production method are as follows: 1, selection of the raw material ratio; 2, selection of appropriate temperature, to be more specific, the temperature is as low as possible under possible conditions;3, selection of reaction time; and 4, selection of a catalyst, to be more specific, the catalyst is selected for more full reaction to obtain a highest yield. The 3-cyanopyridine production method has the advantages of simple production process, low production cost and no pollution, the product yield can reach 70%, the content can reach 90%; the main use of the product is as follows: 1. 3-cyanopyridine is used as a dye intermediate; 2. the 3-cyanopyridine is used as a pesticide pymetrozine intermediate, rodenticide pyridyl phenylcarbamates and mieshujing intermediate; 3. and the 3-cyanopyridine is used as a pharmaceutical intermediate, pigment intermediate, resin intermediate, and the like, and also used as an important chemical intermediate.

Description

Technical field: [0001] The invention belongs to the field of pesticide production, in particular to a production method of tricyanopyridine. Background technique: [0002] Tricyanopyridine, Chinese alias 3-pyridinecarbonitrile, niconitrile, etc., molecular formula C6H4N2, molecular weight 104.11, appearance: white crystal, capable of sublimation, soluble in ethanol, ether, chloroform, benzene and petroleum ether, slightly soluble in water . According to existing reports, the synthetic method of international and domestic tricyanopyridines has the following routes: 1. nicotinamide method, nicotinamide method refers to nicotinamide and catalyst P2O5 react in molten state to prepare 3-cyanopyridine, The reaction yield is 83% to 84%. Although the yield of 3-cyanopyridine produced by this method is relatively high, we can see from the source of raw materials and the reaction process that this method is only suitable for laboratory use; 2.2- Methylglutaronitrile oxidation metho...

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Problems solved by technology

According to existing reports, the synthetic method of international and domestic tricyanopyridines has the following routes: 1. nicotinamide method, nicotinamide method refers to nicotinamide and catalyst P2O5 react in molten state to prepare 3-cyanopyridine, The reaction yield is 83% to 84%. Although the yield of 3-cyanopyridine produced by this method is relatively high, we can see from the source of raw materials and the reaction process that this method is only suitable for laboratory use; 2.2- Methylglutaronitrile oxidation method, 2-methylglutaronitrile is directly oxidized to produce 3-cyanopyridine. The raw materials of this process route are relatively easy to obtain, and the by-products of adiponitrile produced from acrylonitrile are rationally utilized. At the same time, the reaction The device is a fixed bed reactor, which can be produced continuously and has good industrialization prospects, but there are few reports at present; 3. Ammoxidation method, ammoxidation refers to the reaction of olefins, aromatics, alkanes and their derivatives with air (oxygen), ammonia A type of reaction in which gas is mixed and reacted on a catalyst to obtain cyanide compounds