A kind of cross-linked polyglutamic acid suspension and its preparation method and application
A technology of polyglutamic acid and polyglutamate, which is applied in the direction of pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., to achieve the effects of simple preparation methods, reducing the possibility of allergies to complex additives, and facilitating industrial production
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Embodiment 1
[0028] Add 0.6g of polyethylene glycol diglycidyl ether into 80g of deionized water, stir well, then add 12g of sodium polyglutamate with an average molecular weight of 800kDa, mix well, keep warm at 50°C for 8h, add 6000g of deionized water, 8000r / min homogenate for 40min, the particle size of the homogenate is d(90)<280 μm (ninety percent of the particle diameter is less than 280 microns), add 0.6g relative average molecular weight to the homogenate product and be 50kDa potassium polyglutamate, stir Evenly, the suspension of cross-linked polyglutamic acid with salt is obtained.
Embodiment 2
[0030] Add 2.5g of ethylene glycol diglycidyl ether into 120g of deionized water, stir evenly, then add 25g of polyglutamic acid with an average molecular weight of 2000kDa, mix evenly, keep warm at 65°C for 2h, add 32000g of polyglutamic acid containing 0.50wt% paraben Ester deionized aqueous solution, 25000r / min homogenization for 20min, homogenization to particle size d (90) <200μm (ninety percent of the particle diameter is less than 200μm); add 7.5g relative average molecular weight of 2000kDa to the homogenization product Sodium polyglutamate, stirred evenly, obtains the suspension of cross-linked polyglutamic acid with salt added.
Embodiment 3
[0032] Add 1.5g of ethylene glycol diglycidyl ether into 100g of deionized water, stir evenly, then add 18g of sodium polyglutamate with an average molecular weight of 1500kDa, mix evenly, and keep warm at 60°C for 4.5h, then add 16133g of sodium polyglutamate containing 0.25wt% benzene Oxygen ethanol deionized water solution, 15000 r / min homogenate for 30min, homogenate to particle size d(90)<200μm (ninety percent of the particle diameter is less than 200μm); add 3.5g average molecular weight 2000kDa to the homogenate product sodium polyglutamate, and stir evenly to obtain a suspension of cross-linked polyglutamate with salt added.
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