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A kind of cross-linked polyglutamic acid suspension and its preparation method and application

A technology of polyglutamic acid and polyglutamate, which is applied in the direction of pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., to achieve the effects of simple preparation methods, reducing the possibility of allergies to complex additives, and facilitating industrial production

Active Publication Date: 2017-12-26
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And the cross-linked polyglutamic acid suspension lotion that integrates thickening, moisturizing, whitening and other effects has not been reported yet.

Method used

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  • A kind of cross-linked polyglutamic acid suspension and its preparation method and application
  • A kind of cross-linked polyglutamic acid suspension and its preparation method and application
  • A kind of cross-linked polyglutamic acid suspension and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Add 0.6g of polyethylene glycol diglycidyl ether into 80g of deionized water, stir well, then add 12g of sodium polyglutamate with an average molecular weight of 800kDa, mix well, keep warm at 50°C for 8h, add 6000g of deionized water, 8000r / min homogenate for 40min, the particle size of the homogenate is d(90)<280 μm (ninety percent of the particle diameter is less than 280 microns), add 0.6g relative average molecular weight to the homogenate product and be 50kDa potassium polyglutamate, stir Evenly, the suspension of cross-linked polyglutamic acid with salt is obtained.

Embodiment 2

[0030] Add 2.5g of ethylene glycol diglycidyl ether into 120g of deionized water, stir evenly, then add 25g of polyglutamic acid with an average molecular weight of 2000kDa, mix evenly, keep warm at 65°C for 2h, add 32000g of polyglutamic acid containing 0.50wt% paraben Ester deionized aqueous solution, 25000r / min homogenization for 20min, homogenization to particle size d (90) <200μm (ninety percent of the particle diameter is less than 200μm); add 7.5g relative average molecular weight of 2000kDa to the homogenization product Sodium polyglutamate, stirred evenly, obtains the suspension of cross-linked polyglutamic acid with salt added.

Embodiment 3

[0032] Add 1.5g of ethylene glycol diglycidyl ether into 100g of deionized water, stir evenly, then add 18g of sodium polyglutamate with an average molecular weight of 1500kDa, mix evenly, and keep warm at 60°C for 4.5h, then add 16133g of sodium polyglutamate containing 0.25wt% benzene Oxygen ethanol deionized water solution, 15000 r / min homogenate for 30min, homogenate to particle size d(90)<200μm (ninety percent of the particle diameter is less than 200μm); add 3.5g average molecular weight 2000kDa to the homogenate product sodium polyglutamate, and stir evenly to obtain a suspension of cross-linked polyglutamate with salt added.

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Abstract

The invention belongs to the application field of cross-linked high molecular polymers, and in particular relates to a suspension of cross-linked polyglutamic acid and its preparation method and application. The invention provides a preparation method of cross-linked polyglutamic acid suspension: (1) Add cross-linking agent into deionized water, stir evenly, then add polyglutamic acid and / or polyglutamate, stir (2) add deionized water to the premix for homogenization; (3) add 0.6-7.5 parts of glutamate compounds to the homogenate product, stir evenly, and obtain Linked Polyglutamic Acid Suspension. The preparation method is simple to operate and easy to industrialized production; the viscosity drop rate of the cross-linked polyglutamic acid suspension prepared by the method is less than 10% in 12 months, and the subjective feeling is that the viscosity reduction is not obvious; the cross-linked polyglutamic acid prepared by the present invention The acid suspension is applied to viscous moisturizing and whitening lotion, and the lotion has the characteristics of viscous, moisturizing and whitening effects in one.

Description

technical field [0001] The invention belongs to the application field of cross-linked high molecular polymers, and in particular relates to a suspension of cross-linked polyglutamic acid and its preparation method and application. Background technique [0002] Polyglutamic acid is a homopolyglutamic acid straight-chain linear polymer connected by γ-amide bonds, which can be obtained by biological fermentation of Bacillus subtilis. A large number of peptide bonds on the main chain of polyglutamic acid are susceptible to light, heat and hydrolytic enzymes in the environment, degraded into non-toxic short peptides or glutamic acid monomers, so polyglutamic acid can be naturally degraded, safe and environmentally friendly to use . [0003] Polyglutamic acid molecules contain a large number of hydrophilic carboxyl groups, amino groups and hydroxyl groups, and have good water absorption and moisturizing properties. It is a commonly used moisturizer in the field of cosmetics. The...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L77/04C08J3/24C08K5/17A61K8/88A61K8/04A61Q19/02A61Q19/00
CPCA61K8/044A61K8/88A61Q19/00A61Q19/02C08J3/24C08J2377/04C08K5/175C08L77/04C08L2205/025
Inventor 陈勉陈磊刘飞朱希强刘霞张林军刘少英张祥奎凌沛学于林艳钊倩倩
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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