Desloratadine citrate disodium freeze-dried oral instant tablets and preparing method thereof

A technology of oral instant tablets and loratadine, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., to achieve considerable economic and social benefits, high mechanical strength and wear resistance , good drug compliance

Active Publication Date: 2016-07-20
HEFEI HUAFANG PHARMA SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no effective treatment for urticaria, and antihistamines are mostly used orally.

Method used

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  • Desloratadine citrate disodium freeze-dried oral instant tablets and preparing method thereof
  • Desloratadine citrate disodium freeze-dried oral instant tablets and preparing method thereof
  • Desloratadine citrate disodium freeze-dried oral instant tablets and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Each tablet contains 8.8 mg of desloratadine citrate, and the composition of 1000 desloratadine citrate freeze-dried oral instant tablets is as follows:

[0033]

[0034]

[0035] The preparation method is as follows:

[0036] (1) Dissolve the prescribed amount of sulfobutyl ether-β-cyclodextrin in purified water of 80% of the total amount of prescribed water, heat to 45°C under stirring, slowly add the prescribed amount of desloratadine citrate , continue stirring for 24 hours;

[0037] (2) Weigh the prescribed amount of mannitol, lactose, and sucralose, and add them to the solution in step (1).

[0038] (3) Gelatin and xanthan gum of prescription quantity are taken by weighing, be dissolved in the purified water of prescription water consumption 20%, be heated to fully dissolving;

[0039] (4) Combine the above two solutions and stir evenly, adjust the pH value to 5.5-6.5 with citric acid, and add a small amount of tartrazine;

[0040](5) After measuring the ...

Embodiment 2

[0044] Each tablet contains 8.8 mg of desloratadine citrate, and the composition of 1000 desloratadine citrate freeze-dried oral instant tablets is as follows:

[0045]

[0046]

[0047] The preparation method is as follows:

[0048] (1) Dissolve the prescribed amount of sulfobutyl ether-β-cyclodextrin in purified water of 80% of the total amount of prescribed water, heat to 45°C under stirring, slowly add the prescribed amount of desloratadine citrate , continue stirring for 24 hours;

[0049] (2) Weigh the prescribed amount of mannitol, lactose, and sucralose, and add them to the solution in step (1).

[0050] (3) Gelatin and xanthan gum of prescription quantity are taken by weighing, be dissolved in the purified water of prescription water consumption 20%, be heated to fully dissolving;

[0051] (4) Combine the above two solutions and stir evenly, adjust the pH value to 5.5-6.5 with citric acid, and add a small amount of tartrazine;

[0052] (5) After measuring the...

Embodiment 3

[0056] Each tablet contains 8.8 mg of desloratadine citrate, and the composition of 1000 desloratadine citrate freeze-dried oral instant tablets is as follows:

[0057]

[0058]

[0059] The preparation method is as follows:

[0060] (1) Dissolve the prescribed amount of sulfobutyl ether-β-cyclodextrin in purified water of 80% of the total amount of prescribed water, heat to 45°C under stirring, slowly add the prescribed amount of desloratadine citrate , continue stirring for 24 hours;

[0061] (2) Weigh the prescribed amount of mannitol, lactose, and sucralose, and add them to the solution in step (1).

[0062] (3) Gelatin and xanthan gum of prescription quantity are taken by weighing, be dissolved in the purified water of prescription water consumption 20%, be heated to fully dissolving;

[0063] (4) Combine the above two solutions and stir evenly, adjust the pH value to 5.5-6.5 with citric acid, and add a small amount of tartrazine;

[0064] (5) After measuring the...

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PUM

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Abstract

The invention discloses desloratadine citrate disodium freeze-dried oral instant tablets and a preparing method thereof, and belongs to the field of preparation of desloratadine citrate disodium freeze-dried oral instant tablets. The desloratadine citrate disodium freeze-dried oral instant tablets are prepared from, by weight, 5-20 parts of desloratadine citrate disodium, 30-80 parts of framework materials, 10-30 parts of cyclodextrin, 1-10 parts of a suspending agent, 0.1-5 parts of a flavoring agent, 0.1-2 parts of a pH regulating agent and 0.001-0.01 part of a coloring agent. The desloratadine citrate disodium freeze-dried oral instant tablets are good in appearance, small in friability, good in taste, short in melting time, capable of taking effect fast, convenient to carry and good in taking compliance.

Description

technical field [0001] The invention relates to oral fast-disintegrating tablets, and also relates to a preparation method of the desloratadine citrate freeze-dried oral instant tablets, belonging to the field of preparation of desloratadine citrate freeze-dried oral instant tablets. technical background [0002] Urticaria is "a group of heterogeneous diseases with unique and identical skin manifestations". It is a common allergic skin disease with clinical features such as protracted disease course, recurrent attacks, and difficult to cure. Its clinical manifestations are as follows: Itchy skin that appears as pale, bright red, or skin-colored wheals. In some cases, edematous erythema will appear, and the shape and size of the wheal of each patient are different, and the time of attack is not fixed. The cause of the disease is often not found. About 1 / 3 of patients with chronic urticaria have abnormal autoimmune function. Patients have red, swollen and itchy rashes on thei...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/48A61K47/26A61K47/42A61K47/36A61K31/4545A61P17/00A61P37/08
CPCA61K9/006A61K9/2018A61K9/205A61K9/2063A61K31/4545
Inventor 杨贤龙何勇吴宗好封保龙高永好
Owner HEFEI HUAFANG PHARMA SCI & TECH
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