Application of norathyriol in preparation of medicaments and health-care products for preventing and treating chronic kidney disease
A technology of chronic kidney disease and mangiferin aglycone is used in the field of preparation of mangiferin aglycone as a medicine for preventing and treating kidney damage caused by different etiologies and nephropathy
Inactive Publication Date: 2016-07-20
KUNMING MEDICAL UNIVERSITY
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Problems solved by technology
Pharmacological studies have shown that mangiferin has various pharmacological activities such as anti-oxidation, anti-tumor, inhibition of xanthine oxidase and PTP1B activity, improvement of insulin resistance, lowering blood sugar, lowering lipids, anti-inflammation, and inhibition of benign prostatic hyperplasia. Prevention and treatment of kidney disease reports
Method used
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Embodiment Construction
[0024] 1. Effects of Compounds of the Invention on Uric Acid-Induced Kidney Injury
[0025] 60 Kunming mice were randomly divided into 6 groups, 10 in each group, respectively normal control group, model group, mangiferin low-dose group (1.0mg / kg), mangiferin middle-dose group (2.0mg / kg ), mangiferin high dose group (4.0mg / kg) group and positive control benzbromarone group (12.5mg / kg). Except for the animals in the normal control group, the animals in each group were intraperitoneally injected with 100 mg / kg of uric acid to induce kidney damage, twice a day for a total of 10 days. At the same time, the animals in the normal group and the model group were given carboxymethylcellulose sodium (CMC-Na) of 0.5% by intragastric administration, and each drug group was given mangiferin 1.0, 2.0 and 4.0 mg / kg and benzbromarone 12.5 mg / kg respectively. , administered by intragastric administration at 20ml / kg, once a day, for 10 days in total. At the end of the experiment, the eyeballs...
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The invention discloses application of norathyriol in preparation of medicaments and health-care products for preventing and treating chronic kidney disease and belongs to preparation of ketone compounds as the medicaments. The norathyriol comprises oral medicines, like in the medicaments and the health-care products for preventing and treating chronic kidney disease. Experiments show that the norathyriol fed by intragastric administration has a good preventing and treating effect for mice with hyperuricemia and high glucose-induced kidney injury and uric acid-induced kidney injury and animals with diabetic nephropathy, and can be used for remarkably reducing levels of serum creatinine and urea nitrogen of the animals and remarkably improving kidney functions. Histopathology shows that the norathyriol can be used for significantly improving the changes of glomeruli and kidney tubules caused by hyperuricemia and hyperglycemia. The norathyriol disclosed by the invention has high activity and good development and application prospect.
Description
technical field [0001] The invention belongs to a method for preparing a ketone compound as a medicine, and particularly relates to the use of mangiferin as a medicine for preventing and treating kidney damage and nephropathy caused by different causes. Background technique [0002] Chronic kidney disease (chronickidney disease, CKD) has a complex etiology, including primary glomerulonephritis, tubulointerstitial disease, hypertension, diabetes, gout, hyperuricemia, lupus erythematosus, allergic purpura, and hereditary nephropathy. End-stage renal disease (ESRD), which leads to CKD, necessitates alternative treatments such as kidney dialysis or kidney transplantation, which cause huge economic and mental pressure for patients, and can only prolong the survival of some patients. The incidence of CKD in European and American countries is between 6 and 16%, and 23 million Americans suffer from CKD [NymanHA. Renal Dosing in High-Risk Populations. Journal of Infusion Nursing 20...
Claims
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Patent Timeline
Login to View More IPC IPC(8): A61K31/352A61P13/12A23L33/10
CPCA23V2002/00A61K31/352A23V2200/30A23V2250/30
Inventor 李玲高丽辉刘旭林华牛艳芬涂彩霞
Owner KUNMING MEDICAL UNIVERSITY