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Application of Dodecyl Chitosan in Preparation of Hemostatic Dressing

A dodecyl shell and chitosan technology, applied in bandages, absorbent pads, medical science, etc., can solve problems such as delayed wound healing, unstable intermediate Schiff base, and fibrin glue derived from blood

Active Publication Date: 2019-06-25
SANITARY EQUIP INST ACAD OF MILITARY MEDICAL SCI PLA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Conventional hemostasis methods such as artificial extrusion, cautery and wound sutures sometimes cannot effectively stop bleeding and require the use of hemostatic materials
Commonly used hemostatic materials include gelatin, collagen, fibrin glue, α-cyanoacrylate glue, porous zeolite, etc. Although these materials have their own advantages, they also have some defects: tissue adhesion of gelatin and collagen Poor[1]; fibrin glue is derived from blood and can cause viral infection[2]; toxic substances such as cyanide and formaldehyde are released during the degradation of α-cyanoacrylate glue, causing delayed wound healing[3]; porous Zeolite will release a lot of heat after absorbing the water in the blood [4] and so on
However, the intermediate Schiff base formed by the reaction is extremely unstable in aqueous solution [13], and it is easy to re-decompose into the initial reactant, and the reducing agent is also easy to decompose in water, so the search for a suitable solvent and reducing agent is reductive amination The key to the preparation of alkylated chitosan

Method used

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  • Application of Dodecyl Chitosan in Preparation of Hemostatic Dressing
  • Application of Dodecyl Chitosan in Preparation of Hemostatic Dressing
  • Application of Dodecyl Chitosan in Preparation of Hemostatic Dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The preparation method of dodecyl chitosan powder, comprises the steps:

[0041] (1) dissolving chitosan (CS) with a viscosity-average molecular weight of 650,000 and a degree of deacetylation of 95% in an aqueous acetic acid solution with a volume concentration of 1%, stirring until completely dissolved; the chitosan and the aqueous acetic acid solution The ratio is 2g:100mL;

[0042] (2) Add 1mol / L aqueous sodium hydroxide solution to the solution obtained in step (1) to adjust the pH to 12 to produce chitosan precipitation; filter and dissolve the filter cake in dimethylformamide; the filter cake product The ratio with dimethylformamide is 5g:150mL; add lauric aldehyde (Aladdin, Shanghai) according to the ratio of the number of chitosan repeating unit molecules to the number of lauric aldehyde molecules, and adjust the pH with acetic acid to 6.5, stirred at room temperature for 6 h; under nitrogen, added sodium triacetoxyborohydride (STAB-H, Kramar, Shanghai) equimo...

Embodiment 2

[0047] The preparation method of dodecyl chitosan powder, comprises the steps:

[0048] (1) be 300,000, the chitosan of degree of deacetylation 92% to be dissolved in the acetic acid aqueous solution that volume concentration is 1% by viscosity-average molecular weight, stir until fully dissolving; The ratio of described chitosan and described acetic acid aqueous solution is 2g: 50mL;

[0049] (2) Add 1mol / L aqueous sodium hydroxide solution to the solution obtained in step (1) to adjust the pH to 8 to produce chitosan precipitation; filter and dissolve the filter cake in dimethylformamide; the filter cake product The ratio with dimethylformamide is 5g:100ml; the ratio of the number of chitosan repeating unit molecules to the number of laurylaldehyde molecules is 5:1, add lauric aldehyde, adjust the pH to 7 with acetic acid, and stir at room temperature 4h; add sodium triacetoxyborohydride equimolar with laurylaldehyde under nitrogen, continue to react for 12h, filter, filter...

Embodiment 3

[0053] The preparation method of dodecyl chitosan powder, comprises the steps:

[0054] (1) be 1,000,000, the chitosan of degree of deacetylation 98% to be dissolved in the acetic acid aqueous solution that volume concentration is 1% by viscosity-average molecular weight, stir until fully dissolving; The ratio of described chitosan and described acetic acid aqueous solution is 2g: 100mL;

[0055] (2) Add 1mol / L aqueous sodium hydroxide solution to the solution obtained in step (1) to adjust the pH to 10 to produce chitosan precipitation; filter and dissolve the filter cake in dimethylformamide; the filter cake product The ratio with dimethylformamide is 5g:200ml; Add laurylaldehyde according to the ratio of 10:3 between the number of chitosan repeating unit molecules and the number of laurylaldehyde molecules, adjust the pH to 5 with acetic acid, and stir at room temperature 8h; Add sodium triacetoxyborohydride equimolar with laurylaldehyde under nitrogen, continue to react f...

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Abstract

The invention discloses application of dodecyl chitosan in preparing a hemostasis dressing.It is proved through experiments that after being prepared into hemostasis sponge, dodecyl chitosan fast stops arterial hemorrhage and is suitable for emergency aid and treatment on arterial hemorrhage of the wounded in disaster rescue, anti-terrorist emergency and field operation.

Description

technical field [0001] The invention relates to an application of dodecyl chitosan, in particular to an application of dodecyl chitosan in preparing a hemostatic dressing. Background technique [0002] Excessive blood loss is the leading cause of death from war injuries, as well as during accidents and surgical procedures. Conventional methods of hemostasis, such as artificial extrusion, cauterization, and wound suturing, sometimes cannot effectively stop bleeding, and require the use of hemostatic materials. Commonly used hemostatic materials include gelatin, collagen, fibrin glue, α-cyanoacrylate glue, porous zeolite, etc. Although these materials have their own advantages, they also have some defects: tissue adhesion of gelatin and collagen Poor[1]; fibrin glue is derived from blood and can cause viral infection[2]; toxic substances such as cyanide and formaldehyde are released during the degradation of α-cyanoacrylate glue, causing delayed wound healing[3]; porous Zeol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/44A61L15/28
CPCA61L15/28A61L15/44A61L2300/232A61L2300/418C08L5/08
Inventor 关静刘璐韩香李志宏张庆云杨健田丰武继民
Owner SANITARY EQUIP INST ACAD OF MILITARY MEDICAL SCI PLA
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