Hand-written surface-enhanced Raman scattering substrate, and preparation method and application thereof

A surface-enhanced Raman and substrate technology, applied in Raman scattering, material analysis through optical means, measurement devices, etc., can solve the problems that hinder the rapid transformation of SERS detection and analysis technology, are not suitable for large-scale production, and require high templates. problems, to achieve good detection consistency, suitable for large-scale production, and good stability

Active Publication Date: 2016-07-20
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among them, the first method was mainly realized in the early stage by the technology of roughening the electrode surface by electrochemical method. The reinforcement effect of this kind of substrate is poor. With the development of physical technology methods, etching technology is also used in the preparation of high-efficiency substrates, such as : Electron beam etching, concentrated ion beam, etc., but this kind of technology has the disadvantages of high equipment requirements and high production costs
In the second method, the requirements for the template are relatively high, the preparation process is complicated, and it is not suitable for large-scale production
These problems in the preparation of SERS active substrates hinder the rapid transformation of SERS detection and analysis technology from scientific research to practical application

Method used

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  • Hand-written surface-enhanced Raman scattering substrate, and preparation method and application thereof
  • Hand-written surface-enhanced Raman scattering substrate, and preparation method and application thereof
  • Hand-written surface-enhanced Raman scattering substrate, and preparation method and application thereof

Examples

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Embodiment 1

[0055] A method for preparing a handwritten surface-enhanced Raman scattering substrate, comprising the following steps:

[0056] (1) prepare gold nanorod particle suspension, method is as follows:

[0057] Preparation of gold nanometer seed solution: Add 5 mL of 0.2M cetyltrimethylammonium bromide solution, 4.5 mL of deionized water and 500 μL of 5 mM chloroauric acid solution in a clean 50 mL centrifuge tube , mix well, and then add 600 μL of freshly prepared 10 mM sodium borohydride solution at freezing point temperature dropwise, stir rapidly for 2 min, and stand at room temperature for 2 h for later use.

[0058] Growth solution preparation: Take a clean 50mL centrifuge tube, add 6mL of 0.2M cetyltrimethylammonium bromide solution, 1.2mL of 5mM chloroauric acid solution, 12μL of 0.1M silver nitrate solution, 10 μL of 1.2M hydrochloric acid solution and 720 μL of 10 mM ascorbic acid solution were stirred evenly, then 10 μL of the prepared gold nanorod seed solution was ad...

Embodiment 2

[0064] A method for preparing a handwritten surface-enhanced Raman scattering substrate, comprising the following steps:

[0065] (1) prepare gold nanoparticle suspension, method is as follows:

[0066] Preparation of gold seeds: Add 5 mL of 0.2 M cetyltrimethylammonium bromide solution, 4.5 mL of deionized water and 500 μL of 5 mM chloroauric acid solution in a clean 50 mL centrifuge tube, mix Mix well, then add 600 μL of freshly prepared 10 mM sodium borohydride solution at freezing point temperature dropwise, stir rapidly for 2 min, let stand at room temperature for 2 h, and set aside.

[0067] Preparation of growth solution: Take a clean 50mL centrifuge tube, add 6mL of 0.2M cetyltrimethylammonium bromide solution and 1.2mL of 5mM chloroauric acid solution, mix well, then add 50μL of 1M Adjust the pH to 10 with sodium hydroxide solution, add 500 μL of 10 mM ascorbic acid solution, stir rapidly, and finally add 12 μL of seeds, react for 1 hour and centrifuge to remove exce...

Embodiment 3

[0071] A method for preparing a handwritten surface-enhanced Raman scattering substrate, comprising the following steps:

[0072] (1) prepare porous gold nanoparticle suspension, method is as follows:

[0073] Preparation of gold seeds: Add 10mL of 0.1M cetyltrimethylammonium chloride solution and 250μL of 10mM chloroauric acid solution to a clean 50mL centrifuge tube, stir well, and then quickly add 300μL of The freshly prepared 10 mM freezing point sodium borohydride solution was stirred rapidly for 1 min, left to stand at room temperature for 2 h, diluted 50 times with deionized water, and set aside.

[0074] Preparation of growth solution: Take a clean 50mL centrifuge tube, add 10mL of 0.1M cetyltrimethylammonium chloride solution and 500μL of 10mM chloroauric acid solution, mix well, then add 100μL of 100mM The ascorbic acid solution was stirred quickly, and finally 10 μL of seeds were added. After standing for 4 hours, centrifuge to remove excess unreacted growth soluti...

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Abstract

The invention provides a hand-written surface-enhanced Raman scattering substrate, comprising a flexible substrate and metal nanoparticles distributed in the surface and interior of the flexible substrate, wherein the flexible substrate is paper or a polylactic acid film. The hand-written surface-enhanced Raman scattering substrate has the advantages of good enhancing effect, high stability, excellent detection consistency and low price, and is favorable for rapid analysis of a large number of samples in a laboratory and outdoor on-site detection. The invention also provides a preparation method for the hand-written surface-enhanced Raman scattering substrate. The preparation method comprises the following steps: providing a metal nanoparticle fluid suspension; filling a writing pen with the metal nanoparticle fluid suspension; and writing lines on the flexible substrate with the writing pen to allow the metal nanoparticles to be distributed in the surface and interior of the flexible substrate, thereby obtaining the hand-written surface-enhanced Raman scattering substrate. The preparation method is simple, does not need expensive advanced apparatuses and is suitable for large-scale production.

Description

technical field [0001] The invention relates to the technical field of functional materials, in particular to a handwritten surface-enhanced Raman scattering substrate and a preparation method and application thereof. Background technique [0002] Surface Enhanced Raman Scattering (SurfaceEnhancedRamanScattering, SERS) is the enhancement of the local electromagnetic field generated by the surface plasmon oscillation of the noble metal SERS active substrate and the incident light and the scattered light scattered by molecules during the Raman test. A very efficient technique for detecting Raman signals, it has wide applications in fields such as spectroscopic analysis and biosensing. [0003] SERS is a surface effect that is closely related to the nature of adsorbed species on the substrate surface, the type of active substrate, and the surface roughness. When a molecule is adsorbed on a rough solid surface or a metal nanoparticle surface, the Raman signal of the molecule wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65G01N21/01
Inventor 喻学锋唐思莹郭志男李鹏辉
Owner SHENZHEN INST OF ADVANCED TECH
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