Pulse-controlled release tablet containing fluticasone furoate and vilanterol and preparation method thereof

A technology of fluticasone furoate and controlled-release tablets, which is applied in the field of pulse controlled-release tablets containing fluticasone furoate and vilanterol and its preparation, which can solve problems such as complicated operation steps, toxic and side effects of preparations, and difficulty in achieving inhalation speed
CN105796522BInactive Publication Date: 2018-09-21HYBIO PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HYBIO PHARMA
Publication Date
2018-09-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a pulsatile controlled-release tablet containing fluticasone furoate and vilanterol. The pulsatile controlled-release tablet can reach plasma concentration at midnight and early morning, so the purpose of chrono-chemotherapy is achieved. The pulsatile controlled-release tablet comprises a floating layer and a tablet core. The floating layer uses hydrophilic high molecules and fatty alcohol as adjuvant materials, so the floating layer can retain for a certain period of time in the stomach; when the tablet contacts with gastric juice, the surface of the floating layer hydrates to form gel, so the size of the tablet becomes larger; when the gel is smaller than the concentration of the gastric juice, the tablet is allowed to float above contents in the stomach; and the tablet core appears along with dissolution of the skeleton of the floating layer, so drugs are released from the tablet core.
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Description

technical field

[0001] The invention belongs to the field of medicinal chemistry, and in particular relates to a pulse-controlled release tablet containing fluticasone furoate and vilanterol and a preparation method thereof. Background technique

[0002] Bronchial asthma is a chronic inflammatory disease of the airways that involves a variety of cells (such as eosinophils, mast cells, T lymphocytes, neutrophils, airway epithelial cells, etc.) and cell components. This chronic inflammation leads to the generation of airway hyperresponsiveness, usually with widespread and variable reversible airflow limitation, and causes recurrent symptoms such as wheezing, shortness of breath, chest tightness or coughing, often at night and / or in the early morning, Most patients can be relieved spontaneously or after treatment.

[0003] Chronic obstructive pulmonary disease (COPD) is a chronic bronchitis and / or emphysema characterized by airflow obstruction, a common chronic disease that ca...

Claims

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