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Applications of Chinese pine wood and extract thereof in medicine for treating osteoporosis

A technology for osteoporosis and osteoporosis, which is used in drug combinations, medical preparations containing active ingredients, medical raw materials derived from gymnosperms, etc.

Inactive Publication Date: 2016-07-27
庄信修 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment plan for osteoporosis mainly focuses on chemical drugs, which are divided into bone resorption inhibitors (including estrogen, selective estrogen receptor modulators (SERMs), calcitonin, bisphosphonates, etc.) and bone formation stimulators (including fluoride, small doses of parathyroid hormone (PTH), etc.), but studies have shown that the use of hormone replacement therapy can significantly increase the incidence of breast cancer and increase the incidence of coronary heart disease, stroke and The risk of pulmonary embolism, bisphosphonates also have gastrointestinal reactions, such as nausea, vomiting, abdominal pain, diarrhea, etc. Therefore, in view of the shortcomings of chemical drugs in the treatment of osteoporosis, from the perspective of traditional Chinese medicine, explore the rules and principles of traditional Chinese medicine. How to make full use of its drug advantages in the prevention and treatment of osteoporosis is particularly important

Method used

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  • Applications of Chinese pine wood and extract thereof in medicine for treating osteoporosis
  • Applications of Chinese pine wood and extract thereof in medicine for treating osteoporosis
  • Applications of Chinese pine wood and extract thereof in medicine for treating osteoporosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Effect of Pinus tabulaeformis Extract on Acute Model of Rat Osteoporosis Induced by Retinoic Acid

[0025] SD female rats induced by retinoic acid were used to establish an acute model of rat osteoporosis. After administering 95% ethanol extract of Pinus tabulaeformis for a certain period of time, the second lumbar vertebrae were taken for paraffin section staining, and the bone density of the right femur was measured. The content of alkaline phosphatase and acid phosphatase in the serum was detected, and the changes of Pinus tabulaeformis on bone microstructure, bone mass and bone turnover of rats were observed.

[0026] 1. Experimental materials and methods:

[0027] 1.1 Main instruments and reagents: alkaline phosphatase detection kit (Nanjing Jiancheng Bioengineering Research Institute, A059-1), tartrate-resistant acid phosphatase detection kit (Nanjing Jiancheng Bioengineering Research Institute, A058), Spectra-Max multifunctional Microplate reader (Mol...

Embodiment 2

[0048] Example 2: 95% ethanol extract of Pinus tabulaeformis inhibits bone resorption by osteophagocytic cells

[0049] There are two types of cells in human bones, one of which is osteoclast, which specializes in destroying bones. After finding bones in the body, osteoclasts sit on the surface of the bone and begin to form a closed area. Once the closed period is formed, The calcium in the bone flows out, and the osteophagocytes begin to absorb the bone and form a cavity; another type of osteoblast continuously produces new bone and increases bone density. Generally speaking, before the age of 40, the functions of the two types of cells are in a state of balance and decline, but after the age of 40, the functions of the two types of cells will decline, and the decline rate of osteoblasts is much faster than that of osteophagocytes, so the bone mass begins to lose , resulting in a fragile bone structure, which is the so-called "osteoporosis".

[0050] Step 1: The osteophages ...

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Abstract

The invention discloses applications of Chinese pine wood and an extract of the Chinese pine wood in a medicine for treating osteoporosis. The invention further discloses the medicine for treating osteoporosis, wherein the active ingredient of the medicine contains the Chinese pine wood or the extract of the Chinese pine wood. The invention discloses the novel applications of Chinese pine wood in prevention and treatment for osteoporosis caused by various reasons. The cellular experiment and the pharmacological experiment prove that the Chinese pine wood has the obvious effects in treating osteoporosis, and can be applied to prevention and treatment for osteoporosis.

Description

technical field [0001] The invention relates to a new application of Chinese pine, in particular to the application of Chinese pine and its extract in medicine for treating osteoporosis. Background technique [0002] Osteoporosis (osteoporosis) is a systemic bone disease, characterized by decreased bone mass and destruction of bone microstructure, manifested as increased bone fragility, thus greatly increasing the risk of fracture, even with minor trauma or Fractures are also prone to occur in the absence of trauma. Osteoporosis is a multifactorial chronic disease. Before the fracture occurs, there are usually no special clinical manifestations. The disease is more common in women than in men and is common in postmenopausal women and the elderly. With the increase of the elderly population in my country, the incidence of osteoporosis is on the rise, and it is a health problem worthy of attention in my country and even in the world. At present, the treatment plan for oste...

Claims

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Application Information

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IPC IPC(8): A61K36/15A61P19/10
CPCA61K36/15A61K2236/333A61K2236/39
Inventor 庄信修郑艳华卓云晖
Owner 庄信修