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Equipment and method for detecting vascular endothelial functions by Doppler ultrasonography

A technology of Doppler ultrasound and vascular endothelium, which is applied in the field of detection of vascular endothelial function through Doppler ultrasound, which can solve the problems of complex operation, indirect measurement accuracy, and high equipment cost

Inactive Publication Date: 2016-08-17
北京云智创想信息技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] (2) It is difficult to completely eliminate the influence of the external environment and its own factors (such as activities, caffeine intake, mood swings, and body temperature changes)
[0007] (3) The pulsation of blood vessels will bring difficulties to the accurate measurement of tube diameter
[0008] (4) The cost of equipment is high, the operation is complicated, and it is not suitable for home use
The disadvantage is that the influence of the surrounding environment and autonomic nerves cannot be completely eliminated; the measurement of the pulse wave amplitude is greatly affected by the sensitivity of the sensor, the contact pressure with the skin, and the fat ratio of the fingertips
Direct measurement of vascular diameter change is the gold standard, but the operation is complicated and there are many human factors
The accuracy of indirect measurement is affected by the sensor, and is easily interfered by the environment and its own factors

Method used

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  • Equipment and method for detecting vascular endothelial functions by Doppler ultrasonography
  • Equipment and method for detecting vascular endothelial functions by Doppler ultrasonography
  • Equipment and method for detecting vascular endothelial functions by Doppler ultrasonography

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0118] Taking radial artery detection as an example, the experimental schematic diagram is as follows: Figure 5 Shown: in the figure, 17 is the Doppler ultrasonic blood vessel endothelial function detector host; 18 is the ultrasonic probe wristband, and 19 is the ultrasonic probe slightly pressed on the wrist skin surface; 20 is bound on the ipsilateral upper arm (near the brachial artery 21 is a USB connection; 22 is a PC connected to the detector host through a USB connection.

[0119] The steps of the whole detection process are as follows:

[0120] 1. The subject kept an empty stomach for 12 hours, and after lying down for 15 minutes, put on the cuff on the left upper arm;

[0121] 2. Apply gel on the skin of the left wrist;

[0122] 3. Fix the ultrasound probe on the skin surface coated with coupling agent through the wrist strap;

[0123] 4. The host computer and the PC are connected through the USB cable and turned on separately;

[0124] 5. The probe sends ultraso...

Embodiment 2

[0133] figure 2 It is the Doppler signal-time diagram of the radial artery pulse of a male (56 years old) measured according to the method of Example 1. The abscissa is time, and the ordinate is Doppler signal intensity. At 2 minutes and 18 seconds, the cuff was decompressed and arterial blood flow was restored. Each long vertical line in the figure represents an arterial pulse, and the vertical line above the horizontal line with an intensity value of 0 represents the pulsation on the upper surface of the blood vessel, because the direction of the pulsation is opposite to the direction of ultrasonic emission, and its Doppler signal strength is positive . The vertical line below the zero intensity line represents the pulsation of the lower surface of the blood vessel, because the pulsation direction is the same as the ultrasound emission direction, and its Doppler signal intensity is negative. The sum of the lengths of adjacent positive and negative longitudinal lines repr...

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Abstract

The invention discloses a method and equipment for detecting vascular endothelial function through Doppler ultrasound, which belongs to the technical field of non-invasive medical detection instruments. According to the proportional relationship, the change of the diameter of the artery before and after the blood flow is restored is measured, and the FMD index value of the vascular endothelial function is calculated. The method of the present invention is a direct non-invasive measurement method, which has high sensitivity and high calculation accuracy, and can effectively shield the interference caused by the pulsation of arteries other than the examined artery, and the vein and its congestion state do not interfere with the detection result. The operation is much simpler than the FMD method and does not require special training. The device of the invention has the advantages of small volume, convenient operation, intuitive result and easy popularization.

Description

technical field [0001] The invention relates to the technical field of non-invasive medical detection instruments, in particular to a method and equipment for detecting vascular endothelial function through Doppler ultrasound. Background technique [0002] Vascular endothelial cells are a layer of flat squamous cells that continuously cover the surface of the vascular lumen. It is not only the largest endocrine and paracrine organ in the human body, it can secrete dozens of vasoactive substances, and it is also the target organ of many active substances. Vascular endothelial cells have important physiological functions in regulating vasodilation, maintaining the balance of coagulation and fibrinolytic systems, inhibiting platelet aggregation, inhibiting the adhesion between inflammatory cells and endothelial cells, and regulating the growth of vascular smooth muscle. Before the morphological changes and development of atherosclerosis, the change of endothelial function is in...

Claims

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Application Information

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IPC IPC(8): A61B8/08
CPCA61B8/085A61B8/4411A61B8/488
Inventor 何宗彦
Owner 北京云智创想信息技术有限公司