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Fermented cordyceps sinensis extracellular polysaccharide granules and preparation method thereof

A technology of Cordyceps sinensis cells and granules, which is applied in the fields of extracellular fluid diseases, anti-toxins, and pharmaceutical formulas, and can solve the problems of surrounding water and soil pollution, waste of resources, energy, manpower, material and financial resources, and discarding of fermentation broth.

Inactive Publication Date: 2016-08-24
王辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the waste of resources, energy, manpower, material resources and financial resources after the fermentation liquid of Cordyceps sinensis mycelium is produced by artificial fermentation of Cordyceps sinensis, and there is a problem of polluting the surrounding water and soil, and to meet the market demand for rich exopolysaccharides The demand for component products, the purpose of the present invention is to provide a kind of fermentation liquid after the artificial fermentation of Cordyceps sinensis to produce Cordyceps sinensis mycelium to produce Cordyceps exopolysaccharide granules and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 10.00kg fermented Cordyceps exopolysaccharide granules include:

[0036] 5.00kg fermented Cordyceps sinensis exopolysaccharide, 100 sifted powder;

[0037] 2.60kg of filler, the filler is 0.52kg by weight of lactose plus 2.08kg of soluble starch mixed evenly, pulverized and sieved, 100 sifted powder;

[0038] The slow-release material of 2.00kg, the slow-release material is that the hydroxypropyl methylcellulose of 0.20kg, the ethylcellulose of 0.40kg, the cellulose acetate of 1.40kg are mixed uniformly, crushed and sieved, 100 sieved powder ;

[0039] The binding agent of 0.30kg, described binding agent is that the povidone of 0.30kg is pulverized and sieved, and the sieve powder of 100:

[0040] The disintegrating agent of 0.075kg, described disintegrating agent is that the microcrystalline cellulose of 0.075kg is pulverized and sieved, 100 sieved powder; And

[0041] The flavoring agent of 0.025kg, described flavoring agent is that the stevioside of 0.025kg is pul...

Embodiment 2

[0044] 10.00kg fermented Cordyceps exopolysaccharide granules include:

[0045] 2.00kg fermented Cordyceps sinensis exopolysaccharide, 100 sifted powder;

[0046] 6.00kg of filler, the filler is 1.20kg by weight of lactose plus 4.80kg of soluble starch mixed evenly, pulverized and sieved, 100 sifted powder;

[0047] The slow-release material of 1.34kg, the slow-release material is that the hydroxypropyl methylcellulose of 0.134kg, the ethylcellulose of 0.268kg, the cellulose acetate of 0.938kg are mixed uniformly, crushed and sieved, 100 sieved powder ;

[0048] The binding agent of 0.10kg, described binding agent is that the povidone of 0.30kg is pulverized and sieved, 100 sieved powder;

[0049] 0.05kg of disintegrating agent, the disintegrating agent is crushed and sieved with 0.05kg of microcrystalline cellulose, 100 sieved powder; and

[0050] The flavoring agent of 0.01kg, described flavoring agent is that the stevioside of 0.01kg is pulverized and sieved, and the sieve...

Embodiment 3

[0054] Using Cordyceps sinensis strains, liquid fermentation produces Cordyceps sinensis mycelium;

[0055] After the fermentation, extract the mycelium and collect the fermentation liquid; the fermentation liquid is concentrated with an external heating type three-effect concentrator, and the vacuum degree and evaporation temperature of each effect: the first effect -0.04MPa, 70°C; the second effect -0.06MPa, 60°C : Three-effect -0.08MPa, 50°C, the fermentation broth is concentrated to a relative density of 1.22;

[0056] Adjust the pH of the 50L concentrated fermentation broth to 6.5, let it stand at room temperature for 1.5h, and centrifuge at 3000r / min for 20min to remove the precipitate;

[0057] Add 75% edible ethanol to the container wall at a flow rate of 1L / min and add it to the concentrated fermentation broth after removing sediment at 40 r / min. When the ethanol concentration in the fermentation broth reaches 60%, stop adding, stop stirring, and stand at 0°C for 8h ...

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Abstract

The invention relates to fermented cordyceps sinensis extracellular polysaccharide granules and a preparation method thereof, aims to solve the problems that a fermentation liquid obtained after cordyceps sinensis mycelium production is discarded, resources, energy sources, manpower, material resources and financial resources are wasted and pollution to surrounding water bodies and soil exists, and meets the requirements of markets on products rich in a cordyceps sinensis extracellular polysaccharide component. The preparation method comprises the steps: carrying out strain acquisition, strain cultivation, asepsis separation, low-temperature cultivation, purification, strain identification, original strain preservation, fermentation performance testing, liquid fermentation, bacterial liquid separation, fermentation liquid concentration, and extraction and refining of cordyceps sinensis extracellular crude polysaccharide; taking fermented cordyceps sinensis extracellular polysaccharide related auxiliary materials, evenly mixing and then sieving; and preparing a soft material, granulating, drying, carrying out size stabilization, and thus obtaining the fermented cordyceps sinensis extracellular polysaccharide granules. The product has the functions of resisting tumor, resisting oxidation, enhancing the phagocytic ability of mononuclear macrophage, increasing the content of serum IgG, promoting the transformation of in-vitro lymphocytes, resisting radiation and the like.

Description

technical field [0001] The invention relates to a fermented cordyceps exopolysaccharide granule and a preparation method thereof, in particular to a granule obtained by separating and purifying the fermented cordyceps exopolysaccharide and adding auxiliary materials and a preparation method thereof. Background technique [0002] Fermented Cordyceps sinensis powder is produced through the processes of strain collection, strain cultivation, aseptic separation, low-temperature cultivation, purification, strain identification, original strain preservation, fermentation performance measurement, liquid fermentation, bacterial liquid separation, and mycelium drying. have to. Fermentation liquid is often treated as waste liquid. Since the fermentation liquid contains a large number of microorganisms and other functional components, direct discharge will pollute the surrounding water and soil. It needs to be sterilized by high temperature and high pressure before it can be discharged...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/715A61P35/00A61P39/06A61P7/00A61P17/16
Inventor 王玉花王辉
Owner 王辉
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