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Preparation method and application of orthosiphon aristatus extract

A technology of cat's hair grass and extract is applied in the application field of cat's hair grass extract in the preparation of anti-aging drugs, and can solve the problems of easy development of skin cancer and the like

Inactive Publication Date: 2016-08-31
刘肖娣 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

What's more dangerous is that skin photoaging is also prone to develop skin cancer

Method used

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  • Preparation method and application of orthosiphon aristatus extract
  • Preparation method and application of orthosiphon aristatus extract
  • Preparation method and application of orthosiphon aristatus extract

Examples

Experimental program
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preparation example Construction

[0106] The preparation method of cat's whiskers extract is characterized in that: comprising the following steps,

[0107] Extraction: Take the dry aboveground part or the whole grass of cat's whiskers, cleanly select, cut into sections, add to 5-15 times the amount of distilled water, soak overnight, extract for 1-4 hours, filter; the filtered medicinal residue is extracted with distilled water Once, combine the filtrates, evaporate and concentrate, add distilled water to the concentrated medicinal solution according to crude drug weight: water volume ratio of 1:1, cool to room temperature, and obtain extract A;

[0108] Alcohol precipitation: Take the extract A, add 92%-97% ethanol of 1-3 times the volume of the medicinal solution, stir, let stand at 3-5°C for 22-26 hours, filter, recover ethanol from the filtrate, use ethanol for filter cake and precipitation Wash, filter, and recover ethanol from the washing liquid. Then the recovered solution is combined with the filtrat...

Embodiment 1

[0111] The preparation method of cat's whiskers extract.

[0112] Preparation of Cat's Whiskers Extract: Take the dry aerial part or whole plant of Cat's Whiskers, cleanly select, cut into sections, add to 5 times the amount of distilled water to soak overnight, extract for 1 hour, and filter; Extract once with distilled water, combine the filtrate, evaporate and concentrate, add distilled water to the concentrated medicinal solution according to the ratio of crude drug weight: water volume ratio of 1:1 (that is, the concentration of the medicinal solution is 1g / ml), cool to room temperature, and add the medicinal solution Stir with 95% ethanol of 1 times the volume, let stand at 4°C for 24 hours, filter, recover ethanol from the filtrate, wash the filter cake and precipitate with ethanol, filter, and recover ethanol from the washing solution. Then the recovered solution was combined with the filtrate, concentrated into an extract (that is, the cat's whiskers extract) accordin...

Embodiment 2

[0114] The preparation method of cat's whiskers extract.

[0115] Preparation of Cat's Whiskers Extract: Take the dry aerial part or whole plant of Cat's Whiskers, cleanly select, cut into sections, add to 15 times the amount of distilled water to soak overnight, extract for 4 hours, and filter; Extract once with distilled water, combine the filtrate, evaporate and concentrate, add distilled water to the concentrated medicinal solution according to the ratio of crude drug weight: water volume ratio of 1:1 (that is, the concentration of the medicinal solution is 1g / ml), cool to room temperature, and add the medicinal solution Stir with 3 times the volume of 95% ethanol, let stand at 4°C for 24 hours, filter, recover ethanol from the filtrate, wash the filter cake and precipitate with ethanol, filter, and recover ethanol from the washing solution. Then the recovered solution was combined with the filtrate, concentrated into an extract (that is, the cat's whiskers extract) accord...

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Abstract

The invention belongs to the field of medical technology and discloses a preparation method of an orthosiphon aristatus extract and application thereof in preventing and treating skin aging, and particularly relates to a treatment and protection effect of orthosiphon aristatus on the photoaging of ultraviolet-induced mouse skin. The result indicates that the orthosiphon aristatus can effectively improve the bad conditions such as skin thickening, dryness, loose skin, thick and deep wrinkles and leather-like appearance caused by UV. Meanwhile, the histopathological result indicates that the orthosiphon aristatus can obviously improve the degenerative changes of skin structure caused by UV and maintain normal distribution of collagen fiber and elastic fiber. Moreover, the orthosiphon aristatus can remarkably inhibit the oxidative stress of skin by reducing the lipid peroxidation and increasing the antioxidant enzyme activity, enhance the skin immunity and improve the function of lymphoid organ by inhibiting excessive inflammatory factors, and down-regulate the level of MMP-1 and MMP-3 of photoaging mouse. Experimental result shows that the orthosiphon aristatus can be clinically used for preventing and treating skin aging and can be applied to household chemicals.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to a new drug application of Orthosiphon Stamineus Benth, in particular to the application of Orthosiphon Stamineus Benth extract in preparing anti-aging medicine. Background technique [0002] The theory of traditional Chinese medicine believes that skin aging is mainly due to the deficiency of the five viscera and the insufficiency of qi and blood, which cannot be used to honor the face. Insufficient kidney essence will also lead to lack of source of energy and blood metabolization, and the essence, energy, and blood cannot reach the face, causing the skin to lose nourishment. Therefore, it is advocated that the main treatment method is to nourish the kidney and replenish essence. The natural plant cat's whiskers is the whole herb of the Lamiaceae Lamiaceae kidney tea genus lerodendranthu plant cat's whiskers Orthosiphonstamineus Benth, which is used as medicine with stems an...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K9/20A61K47/36A61P17/16A61P17/18A61K8/97A61Q19/08A61Q17/04
CPCA61K36/53A61K8/97A61K9/2059A61K2236/331A61K2236/39A61K2236/55A61Q17/04A61Q19/08
Inventor 刘肖娣梁伟炳
Owner 刘肖娣
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