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Method for continuous production of acetyl phosphate with microchannel reaction device

A channel reaction device and a technology of acetyl phosphate, which are applied in the fields of chemical synthesis and technology, can solve the problems of low purity and yield of reaction products, and achieve the effects of short reaction time and good mass transfer effect.

Active Publication Date: 2016-08-31
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved in the present invention is to provide a method for continuously producing acetyl phosphate using a microchannel reaction device to solve the problem that the purity and yield of the reaction product in the prior art are not high

Method used

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  • Method for continuous production of acetyl phosphate with microchannel reaction device
  • Method for continuous production of acetyl phosphate with microchannel reaction device
  • Method for continuous production of acetyl phosphate with microchannel reaction device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Configure the methanol solution of phosphoric acid in the first raw material storage tank, the proportioning of phosphoric acid and methyl alcohol is 1mol:300ml, configure the ethyl acetate solution of acetic anhydride in the second raw material storage tank, the proportioning of acetic anhydride and ethyl acetate is 1mol: 200ml. Wait for the pump to enter the microstructure mixer and enter the microchannel reactor for reaction.

Embodiment 2～3

[0040] Pump the first raw material storage tank (methanol solution of phosphoric acid) and the second raw material storage tank (ethyl acetate solution of acetic anhydride) according to the volume flow ratio of 1:2 (embodiment 2), 1:4 (embodiment 3) Put it into the microchannel reactor, keep it for 10min under the reaction condition of 0°C, and take the reaction solution from the microchannel reactor I for detection.

[0041] Selectivity and conversion rate of table 1 embodiment 2~3

[0042] Example Phosphoric acid conversion rate Acetyl phosphate selectivity 2 100％ 94％ 3 100％ 93％

Embodiment 4～6

[0044] The first raw material storage tank (methanol solution of phosphoric acid) and the second raw material storage tank (ethyl acetate solution of acetic anhydride) are pumped into the microchannel reactor according to the volume flow ratio of 1:2.5, at -5 ℃ (embodiment 4 ), 0 ℃ (embodiment 5), 5 ℃ (embodiment 6) reaction conditions, retain 10min, get the reaction liquid detection that microchannel reactor 1 comes out.

[0045] Selectivity and conversion rate of table 2 embodiment 4~6

[0046] Example Phosphoric acid conversion rate Acetyl phosphate selectivity 4 100％ 90％ 5 100％ 92.4％ 6 100％ 87.6％

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Abstract

The invention discloses a method for continuous production of acetyl phosphate with a microchannel reaction device. The method includes the steps of: (1) pumping a phosphoric acid solution and an acetic anhydride solution respectively into a microstructure mixer I at the same time, mixing the substances evenly, then pumping the mixture into a microchannel reactor I and carrying out reaction to obtain an acetyl phosphate solution; (2) pumping the acetyl phosphate solution and an alkali solution respectively into a microstructure mixer II at the same time, and then pumping the mixture into a microchannel reactor II to carry out reaction to obtain an acetyl phosphate solution; and (3) conducting standing, crystallization, filtering and drying on the acetyl phosphate solution to obtain acetyl phosphate. The method provided by the invention can achieve a phosphoric acid conversion rate of 100%, and a acetyl phosphate yield of more than 93%.

Description

technical field [0001] The invention belongs to the field of chemical synthesis and technology, and in particular relates to a method for continuously producing acetyl phosphate using a microchannel reaction device using an alkaline solution of phosphoric acid, acetic anhydride and corresponding salts. Background technique [0002] Acetyl phosphate (ACP) is a high-energy phosphate compound. Its high-energy phosphate bond can regenerate the cofactor ATP in situ under the action of the enzyme, avoiding the consumption of expensive ATP to obtain the product, thereby greatly reducing the production cost of the sample. , and thus are widely used in the field of biocatalysis. Due to the poor stability of acetyl phosphate, it is rapidly degraded into acetic acid and phosphoric acid at room temperature. In practical applications, it is usually made into the form of acetyl phosphate. Compared with acetyl phosphate, acetyl phosphate has better stability, lower transportation and stora...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/09
CPCC07F9/096
Inventor 应汉杰朱晨杰郭凯沈涛濮玲玲
Owner NANJING UNIV OF TECH
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