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Cross-linked PEG polymer coating for improving biocompatibility of medical devices

A technology of polymers and compounds, applied in coatings, other medical devices, devices for coating liquids on surfaces, etc., can solve problems such as durability limitations, and achieve the effect of eliminating pinholes

Inactive Publication Date: 2016-08-31
MEDICAL SURFACE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The durability of prior art covalent PEG coatings is therefore limited due to a single layer of PEG molecules and a single point of attachment for each PEG molecule

Method used

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  • Cross-linked PEG polymer coating for improving biocompatibility of medical devices
  • Cross-linked PEG polymer coating for improving biocompatibility of medical devices
  • Cross-linked PEG polymer coating for improving biocompatibility of medical devices

Examples

Experimental program
Comparison scheme
Effect test

example A

[0032] Quartz crystal microbalance (QCM) gold-coated crystals were coated with the cross-linked PEG coating surface of the present invention using plasma glow discharge polymerization of tris(ethylene glycol) monoethyl ether. The thickness of the coating is monitored by the frequency of the crystal. The film thickness versus time curves in image 3 shown in . The thickness increases linearly with time at a rate of about 2 nm per minute.

example B

[0034] Cross-linked PEG-coated surfaces of the present invention with prior art monolayer PEG-coated surfaces and uncoated surfaces for IgG-HRP (immunoglobulin G-horseradish peroxide conjugate) conjugation Compare. Cross-linked PEG coatings were produced using the plasma glow discharge polymerization method of the present invention using tris(ethylene glycol) monoethyl ether as the monomer source. Traditional single-layer PEG coatings are produced by first coating the surface with an acrylic plasma polymer, followed by reaction of high molecular weight PEG-amine molecules (Mw 1000) with carboxyl groups on the surface using a recognized carbodiimide chemistry . Surfaces were exposed to increasing concentrations of IgG-HRP in PBS for 24 hours, followed by rinsing with PBS. The surface was then contacted with a TMB (3,3',5,5' tetramethylbenzidine) solution for 10 min, followed by the addition of 1 N HCl to stop the reaction. The amount of IgG-HRP bound on the surface was quant...

example C

[0036] The cross-linked PEG-coated surfaces of the present invention were compared to uncoated surfaces for human fibronectin (HFN) binding. Cross-linked PEG coatings were produced using the plasma glow discharge polymerization method of the present invention using tris(ethylene glycol) monoethyl ether as the monomer source. Surfaces were exposed to increasing concentrations of HFN in PBS for 24 hours, followed by rinsing with PBS. The surface was then exposed to 0.5 μg / mL anti-HFN-IgG-HRP solution in PBS containing 0.5% BSA for 2 hours to allow anti-HFN-IgG-HRP to bind to any HFN adsorbed on the surface. The surface was rinsed again with PBS to remove excess anti-HFN-IgG-HRP. The surface was then contacted with the TMB solution for 10 min, followed by the addition of 1N HCl to stop the reaction. The amount of HFN / anti-HFN-IgG-HRP complex bound on the surface was quantified by the color intensity (detected at 450 nm) produced by oxidized TMB. as in Figure 5 As can be seen...

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Abstract

The present invention relates to a cross-linked PEG polymer coating that is hydrophilic, lubricious, and resistant to adsorption of biological matters including proteins and cells. The coating is created using plasma glow discharge polymerization of organic compounds with a formula R(OCH2CH2)nOH, wherein the R is an alkane group with 1-4 carbon atoms and n is 1 to 6.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Patent Application No. 61 / 911,879, filed December 4, 2013, which is hereby incorporated by reference in its entirety. technical field [0003] The invention discloses a method for using the formula R(OCH 2 CH 2 ) n A method for producing a crosslinked PEG polymer coating by plasma glow discharge polymerization of organic compounds of OH, wherein R is an alkyl group having 1 to 4 carbon atoms, and n=1 to 6. Advantageously, such methods produce cross-linked PEG polymer coatings covalently attached to the substrate surface. The degree of cross-linking and thickness of the polymer coating can be controlled by the plasma glow discharge polymerization process parameters, and the thickness can vary in the nanometer to micrometer range. Crosslinked PEG polymer coatings can be formed on a variety of materials including those used in medical catheters, implants, sensors, and c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B05D1/02
CPCA61B5/14532B05D5/04B05D1/62A61B5/14735A61B5/686A61B5/1486A61B5/6801A61B2562/18A61M1/16A61M2205/0238
Inventor 陈小曦
Owner MEDICAL SURFACE