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Method for preparing medical hemostatic sponge by resource utilization of notoginseng stems and leaves

A hemostatic sponge and resource-based technology, applied in the field of medical material preparation, can solve the problems of high infection rate, inability to improve material limitations, poor hemostatic efficiency, etc., and achieve the effect of simple preparation process

Inactive Publication Date: 2016-09-07
裴俊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention: for the hemostatic material added with notoginseng saponin, the limitations of its own material cannot be improved by simply adding it, the hemostatic efficiency is poor, and the infection rate is high. Treatment, collecting the fermentation liquid, and then effectively fermenting the stems and leaves of Panax notoginseng, extracting the saponins of notoginseng by the bacteria, preparing the hydrolyzed gel of the stems and leaves of Panax notoginseng by hydrolyzing the stems and leaves of notoginseng, and organically combining it with the saponins of notoginseng, effectively Solve the limitations of the hemostatic material itself, and effectively improve the hemostatic efficiency of medical sponges

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0018] First collect the mature notoginseng stems and leaves, wash them and dry them naturally, then grind and sieve to prepare 65 mesh notoginseng stems and leaves powder, then mix the notoginseng stems and leaves powder with deionized water at a mass ratio of 2:1 Stir and mix, and place at room temperature to ferment for 8 days; after the fermentation is completed, filter the fermentation broth and collect the filtrate, and then weigh 45 parts of deionized water, 30 parts of the above-mentioned filtrate, 8 parts of glucose, 5 copies of KH 2 PO 4 , 5 parts of MgS0 4 ·7H 2 0 and 7 parts of penicillin were placed in a petri dish, and cultured at 28°C for 40 hours to prepare a fermentation broth; in parts by weight, 35 parts of Panax notoginseng stem and leaf powder, 30 parts of the fermentation broth prepared above and Put 15 parts of sterile water in a fermenter, place the fermenter at 28°C, and culture it on a shaker at 200r / min for 5 days; Wash 3 times with deionized wat...

example 2

[0021] First collect the mature notoginseng stems and leaves, wash them and dry them naturally, then grind and sieve to prepare 72 mesh notoginseng stems and leaves powder, and then mix the notoginseng stems and leaves powder with deionized water at a mass ratio of 2:1 Stir and mix, and place at room temperature to ferment for 9 days; after the fermentation is completed, filter the fermentation broth and collect the filtrate, then weigh 50 parts of deionized water, 30 parts of the above-mentioned filtrate, 5 parts of glucose, 5 copies of KH 2 PO 4 , 5 parts of MgS0 4 ·7H 20 and 5 parts of penicillin were placed in a petri dish, and cultured at 29°C for 44 hours to prepare a fermentation broth; in parts by weight, 40 parts of Panax notoginseng stem and leaf powder, 30 parts of the fermentation broth prepared above and 30 parts of sterile water were placed in a fermenter, and the fermenter was placed at 29°C and cultured on a shaking table at 250r / min for 6 days; Wash 4 time...

example 3

[0024] First collect the mature notoginseng stems and leaves, wash them and dry them naturally, then grind and sieve to prepare 80-mesh notoginseng stems and leaves powder, and then mix the notoginseng stems and leaves powder with deionized water at a mass ratio of 2:1 Stir and mix, and place at room temperature to ferment for 10 days; after the fermentation is completed, filter it and collect the filtrate, then weigh 65 parts of deionized water, 25 parts of the above-mentioned filtrate, 3 parts of glucose, and 3 parts by weight, respectively. Part KH 2 PO 4 , 2 parts of MgS0 4 ·7H 2 0 and 2 parts of penicillin were placed in a petri dish, and cultured at 30°C for 48 hours to prepare a fermentation broth; in parts by weight, 55 parts of Panax notoginseng stem and leaf powder, 30 parts of the fermentation broth prepared above and 15 parts of sterile water were placed in a fermenter, and the fermenter was placed at 30°C and cultured on a shaking table at 300r / min for 7 days; ...

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PUM

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Abstract

The invention relates to a method for preparing a medical hemostatic sponge by resource utilization of notoginseng stems and leaves, and belongs to the field of preparation of medical materials. Hemostatic materials with notoginsenosides added which only have simply added components cannot improve limitation of the material, and the materials have the disadvantages of bad haemostasis efficiency and high infection rate; the method comprises the following steps: fermentation treatment is carried out for notoginseng stems and leaves, fermented bacteria liquid is collected, notoginseng stems and leaves are effectively fermented, notoginsenosides are obtained by bacteria extraction, hydrolysis is carried out for notoginseng stems and leaves in order to prepare hydrolytic gel of notoginseng stems and leaves, the gel and the notoginsenosides are organically combined. The haemostasis time of the medical hemostatic sponge is 55-58 seconds, the sponge can be completely absorbed by human body within 1-2 months, the preparation process is simple, and the sponge is green and environmental protection without pollution.

Description

technical field [0001] The invention relates to a method for preparing a medical hemostatic sponge by resource utilization of notoginseng stems and leaves, and belongs to the field of medical material preparation. Background technique [0002] Regardless of whether the wound is caused by trauma, burns, surgery, acute or chronic wounds, etc., it is necessary to cover the wound with an appropriate covering during the healing process. This covering is called a dressing. Its role is to protect wounds, reduce infection, absorb secretions, maintain body temperature, and promote healing. Traditional dressings are mostly gauze and cotton balls made of cotton fibers. Although they have certain moisture absorption and protection effects, they tend to stick to the wound during the healing process, thereby causing secondary damage. [0003] The structure of the medical sponge is porous, has a large absorption capacity for liquids, and is almost completely permeable to oxygen and carbon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00
CPCA61L24/0005A61L24/0015A61L2300/418A61L2400/04
Inventor 裴俊高玉刚
Owner 裴俊