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Method for synthesizing benzoyl peroxide and benzoyl peroxide synthesized with method

A technology of benzoyl peroxide and benzoyl chloride, applied in the field of benzoyl peroxide and synthesizing benzoyl peroxide, can solve the problems of uneven product particle size, product inclusion of impurities, excessive chloride ions, etc. The effect of uniform particle size, low production cost and easy washing

Active Publication Date: 2016-09-07
SHANGHAI MEDICILON INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The first object of the present invention is to provide a method for synthesizing benzoyl peroxide, so as to solve the problems of safety risks, easy agglomeration of products and uneven particle size of products in the production of benzoyl peroxide synthesized by existing synthetic methods , product inclusion impurities, chloride ion exceeding the standard, etc. do not meet the quality standards of raw materials, the method for synthesizing benzoyl peroxide uses benzoyl chloride, hydrogen peroxide, sodium hydroxide and surfactants as raw materials, The product is obtained through a one-step reaction, which has the advantages of simple process, safe operation, low production cost and high yield, and is suitable for industrial production and wide application

Method used

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  • Method for synthesizing benzoyl peroxide and benzoyl peroxide synthesized with method
  • Method for synthesizing benzoyl peroxide and benzoyl peroxide synthesized with method

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Embodiment 1

[0042] The method for the synthesis of benzoyl peroxide provided by this embodiment comprises the following steps:

[0043] S11. At room temperature, dissolve the surfactant in the reaction solvent and stir, then add 15.65kg of sodium hydroxide and stir until dissolved to obtain a solution. Keep the temperature of the solution between -5 and 5°C, and add 6.04kg of it dropwise Hydrogen peroxide, insulation and stirring after completion of dripping, to obtain sodium peroxide solution;

[0044] S12. Keep the temperature of the sodium peroxide solution between -5 and 5°C, then add 50kg of benzoyl chloride dropwise, keep warm and stir after the dropwise addition, centrifuge the reacted solution, and wash the centrifuged solid with water , to obtain benzoyl peroxide.

Embodiment 2

[0046] The method for the synthesis of benzoyl peroxide provided by the present embodiment specifically comprises the following steps:

[0047]S21. At room temperature, dissolve 150g of sodium lauryl sulfate in 120kg of water, stir for 30 minutes, then add 18.5kg of sodium hydroxide and stir until dissolved to obtain a solution. Keep the temperature of the solution at -5 to 5°C. And dropwise add 24kg mass fraction is 30% hydrogen peroxide, keep warm and stir for 1 hour after the drop is completed, after fully reacting, obtain sodium peroxide solution;

[0048] S22. Keep the temperature of the sodium peroxide solution between -5 and 5°C, then add 50kg of benzoyl chloride dropwise, keep warm and stir for 1 hour after the dropwise addition, centrifuge the reacted solution, and centrifuge the centrifuged solid Carry out washing, obtain benzoyl peroxide product 54kg.

Embodiment 3

[0050] The method for the synthesis of benzoyl peroxide provided by the present embodiment specifically comprises the following steps:

[0051] S31. At room temperature, dissolve 40 g of sodium lauryl sulfate in 24 kg of water, stir for 30 minutes, then add 4.2 kg of sodium hydroxide and stir until dissolved to obtain a solution, and keep the temperature of the solution at -5 to 5°C. And add dropwise 5.5kg mass fraction of 30% hydrogen peroxide, keep warm and stir for 0.5 hour after the drop is completed, after fully reacting, obtain sodium peroxide solution;

[0052] S32. Keep the temperature of the sodium peroxide solution between -5 and 5°C, then add 10 kg of benzoyl chloride dropwise, keep warm and stir for 0.5 hours after the dropwise addition, centrifuge the reacted solution, and centrifuge the centrifuged solid Carry out washing, obtain 10kg benzoyl peroxide product.

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Abstract

The invention provides a method for synthesizing benzoyl peroxide. According to the method for synthesizing benzoyl peroxide, benzoyl chloride, hydrogen peroxide, sodium hydroxide and a surfactant serve as raw materials, the raw materials are subjected to a one step reaction to obtain the product, the method is simple in technology, safe in operation, low in production cost, high in yield and the like, and is suitable for industrial production and wide application. According to the method, in the feeding process, the surfactant is dissolved into a reaction solvent before the sodium hydroxide is added, and therefore the solution overflowing phenomenon when the surfactant is dissolved is effectively avoided. The benzoyl peroxide synthesized with the method has the advantages of being free of blocking, even in granularity, easy to wash and the like, and meets the bulk-pharmaceutical-chemical quality standard recorded by the Chinese pharmacopoeia and the European pharmacopoeia.

Description

technical field [0001] The invention relates to the field of raw material drug synthesis, in particular to a method for synthesizing benzoyl peroxide and the benzoyl peroxide synthesized by the method. Background technique [0002] Benzoyl peroxide is an initiator for synthetic resins, a bleaching agent for flour, oil, and wax, an additive for cosmetics, and a vulcanizing agent for rubber, etc. Due to the particularity of the product and the limitations of the previous preparation methods, the standards for raw materials in the pharmaceutical field have been relatively loose, especially the control of the impurity limit is not strict enough. In comparison, the European Pharmacopoeia has stricter control limits for impurities than the Chinese Pharmacopoeia. The reason is that the current industrialized method for producing benzoyl peroxide has defects, and the crystal particles of the product are uneven, and it is easy to wrap impurities and chloride ions and cannot be remove...

Claims

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Application Information

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IPC IPC(8): C07C407/00C07C409/34
CPCC07C407/00C07C409/34
Inventor 柳慧王朋陈仔玲孙珏
Owner SHANGHAI MEDICILON INC
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