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Traditional Chinese medicine composition for treating hyperlipidemia, preparation method and applications thereof

Inactive Publication Date: 2016-09-14
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the existing prescription has many ingredients, is suitable for the treatment of various diseases, and has the effect of regulating blood lipids at the same time, but its specificity for hyperlipidemia is relatively poor.

Method used

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  • Traditional Chinese medicine composition for treating hyperlipidemia, preparation method and applications thereof
  • Traditional Chinese medicine composition for treating hyperlipidemia, preparation method and applications thereof

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Effect test

Embodiment 1

[0049] The preparation of embodiment 1 Chinese medicine composition

[0050] (1) According to the ratio of 2:2:1 by weight of Huo Mazi, Jin Deng Lantern and Radix Astragali, take Huo Ma Zi, dry Jin Lantern persistent calyx and dry Radix Radix Root respectively;

[0051] (2) preparation of hempseed extract:

[0052] After crushing the hemp seed medicinal material, add petroleum ether 20 times its weight, cold soak for 3 hours, extract under the conditions of ultrasonic power of 300W and temperature of 25°C for 15 minutes, filter to remove the filter residue, and the filtrate is concentrated under reduced pressure to obtain hemp seed Total fat is the hemp seed extract;

[0053] (3) Preparation of brocade lantern extract:

[0054] After washing, drying and pulverizing the dried calyx, 10 times its weight, 75wt% ethanol was used to heat and reflux extraction for 3 times, each time for 2 hours, and the extracts were combined, filtered, concentrated, and vacuum-dried to obtain the...

Embodiment 2

[0059] The preparation of embodiment 2 Chinese medicine composition

[0060] (1) According to the ratio of 1:2:1 by weight of Huo Mazi, Jin Deng Lantern and Radix Astragali, take Huo Ma Zi, dry Jin Lantern persistent calyx and dry Radix Radix Root respectively;

[0061] (2) preparation of hempseed extract:

[0062] After crushing the hemp seed medicinal material, add petroleum ether 15 times its weight, cold soak for 4 hours, extract under the condition of ultrasonic power of 300W and temperature of 22°C for 20 minutes, filter to remove the filter residue, and the filtrate is concentrated under reduced pressure to obtain hemp Kernel total oil is the hemp seed extract;

[0063] (3) Preparation of brocade lantern extract:

[0064] After washing, drying and pulverizing the dried calyx, 15 times its weight, 75wt% ethanol was heated and refluxed for 3 times, each time for 1.5 hours, the extracts were combined, filtered, concentrated, and vacuum-dried to obtain the extract powder....

Embodiment 3

[0069] The preparation of embodiment 3 Chinese medicine composition

[0070] (1) According to the ratio of 1:1.5:1 by weight of Huo Mazi, Jin Deng Lantern and Radix Astragali, take Huo Ma Zi, dry Jin Lantern persistent calyx and dry Radix Radix Root respectively;

[0071] (2) preparation of hempseed extract:

[0072] After the hemp seed medicine is crushed, add petroleum ether 25 times its weight, soak for 2 hours, extract under the conditions of ultrasonic power of 300W and temperature of 28°C for 10 minutes, filter to remove the filter residue, and the filtrate is concentrated under reduced pressure to obtain hemp seed. Kernel total oil is the hemp seed extract;

[0073] (3) Preparation of brocade lantern extract:

[0074] After washing, drying and pulverizing the dried calyx, 8 times its weight, 75wt% ethanol was heated and refluxed for 3 times, each time for 2.5 hours, the extracts were combined, filtered, concentrated, and vacuum-dried to obtain the extract powder. Tha...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating hyperlipidemia, a preparation method and applications thereof, and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine is developed based on mechanism of hyperlipidemia and differentiation theory of traditional Chinese medicine, and is composed of the following components in parts by weight: 2 to 6 parts of hemp seed, 2 to 6 parts of physalis alkekengi, and 1 to 3 parts of radix astragali. The experiment results show that the composition can prominently reduce the serum total cholesterol (TC), serum triglyceride (TG), and low density lipoprotein (LDL-C) of a hyperlipidemia animal model, and is dose-dependent, the effect on reducing serum triglyceride is more prominent, and the treatment effect of the composition is as good as that of lovastatin. Through the research on the effect of the traditional Chinese medicine composition on a hyperlipidemia animal model, people find that the traditional Chinese medicine can treat hyperlipidemia, and can be used to develop a novel drug that can be used to treat hyperlipidemia.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating hyperlipidemia, a preparation method and application thereof, and the invention belongs to the technical field of traditional Chinese medicines. Background technique [0002] With the improvement of living standards and the aggravation of my country's population aging, the prevalence of hyperlipidemia is increasing year by year. Hyperlipidemia is a serious disease that endangers human health, and is an important risk factor for the occurrence and development of atherosclerosis, coronary heart disease, stroke, pancreatitis and diabetes. [0003] At present, Western medicine clinical treatment of hyperlipidemia is mainly based on statins, which also include bile acid-binding resins, acyl-CoA cholesterol acyltransferase inhibitors, fibrates and nicotine, etc., and the lipid-lowering effect is positive. However, regulating lipid metabolism is a long-term treatment process. It...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61P3/06
CPCA61K36/60A61K36/481A61K36/81A61K2236/331A61K2236/333A61K2236/35A61K2236/39A61K2300/00
Inventor 杨宝峰杜智敏王宁
Owner HARBIN MEDICAL UNIVERSITY
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