Preparation method of hydroxylapatite fluorescent material doped with rare earth samarium

A technology of hydroxyapatite and fluorescent materials, applied in the direction of luminescent materials, chemical instruments and methods, etc., can solve problems such as hydroxyl quenching, and achieve the effects of low cost, high luminous intensity, and cheap and easy-to-obtain raw materials

Inactive Publication Date: 2016-09-21
SHAANXI UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hydroxyapatite has excellent biocompatibility and good biodegradability, but conventional rare earth ion-doped hydroxyapatite fluorescent probes are easily quenched by hydroxyl groups in the lattice, making them ideal biological probes The material should have good photochemical stability, particle size in the nanometer scale, and non-toxic effects on organisms, etc.

Method used

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  • Preparation method of hydroxylapatite fluorescent material doped with rare earth samarium
  • Preparation method of hydroxylapatite fluorescent material doped with rare earth samarium
  • Preparation method of hydroxylapatite fluorescent material doped with rare earth samarium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 150

[0025] Example 1 (150°C hydrothermal reaction sample)

[0026] Weigh the calculated amounts of calcium nitrate 1.92 g, potassium dihydrogen phosphate 0.68 g, urea 2.10 g, and samarium nitrate 0.10 g, respectively, and add appropriate amount of distilled water to prepare calcium nitrate aqueous solution, potassium dihydrogen phosphate aqueous solution, urea aqueous solution and samarium nitrate aqueous solution . Under the condition of room temperature and stirring, the prepared above-mentioned solutions were mixed according to the order of calcium nitrate aqueous solution, potassium dihydrogen phosphate aqueous solution, samarium nitrate aqueous solution and urea aqueous solution.

[0027] Under stirring conditions at room temperature, ammonia water (5 mol / L) was added dropwise into the mixed solution, and the pH value of the solution was adjusted to about 10. Continue to stir the suspension for 0.5 h, and control the pH to no longer change to obtain a hydrothermal precursor....

Embodiment 2 120

[0029] Example 2 (120°C hydrothermal reaction sample)

[0030] Weigh the calculated amounts of calcium nitrate 1.92 g, potassium dihydrogen phosphate 0.68 g, urea 2.10 g, and samarium nitrate 0.10 g, respectively, and add appropriate amount of distilled water to prepare calcium nitrate aqueous solution, potassium dihydrogen phosphate aqueous solution, urea aqueous solution and samarium nitrate aqueous solution . Under the condition of room temperature and stirring, the prepared above-mentioned solutions were mixed according to the order of calcium nitrate aqueous solution, potassium dihydrogen phosphate aqueous solution, samarium nitrate aqueous solution and urea aqueous solution.

[0031] Under stirring conditions at room temperature, ammonia water (5 mol / L) was added dropwise into the mixed solution, and the pH value of the solution was adjusted to about 10. Continue to stir the suspension for 0.5 h, and control the pH to no longer change to obtain a hydrothermal precursor....

Embodiment 3 90

[0033] Example 3 (90°C hydrothermal reaction sample)

[0034] Weigh the calculated amounts of calcium nitrate 1.92 g, potassium dihydrogen phosphate 0.68 g, urea 2.10 g, and samarium nitrate 0.10 g, respectively, and add appropriate amount of distilled water to prepare calcium nitrate aqueous solution, potassium dihydrogen phosphate aqueous solution, urea aqueous solution and samarium nitrate aqueous solution . Under the condition of room temperature and stirring, the prepared above-mentioned solutions were mixed according to the order of calcium nitrate aqueous solution, potassium dihydrogen phosphate aqueous solution, samarium nitrate aqueous solution and urea aqueous solution.

[0035] Under stirring conditions at room temperature, ammonia water (5 mol / L) was added dropwise into the mixed solution, and the pH value of the solution was adjusted to about 10. Continue to stir the suspension for 0.5 h, and control the pH to no longer change to obtain a hydrothermal precursor. ...

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Abstract

The invention discloses a preparation method of a hydroxylapatite fluorescent material doped with rare earth samarium. The hydroxylapatite fluorescent material has a high-biocompatibility substrate and is doped with the rare earth samarium, so that a characteristic emission peak can be generated under optical excitation. The hydroxylapatite fluorescent material can be used as a fluorescent mark, a fluorescent probe and the like in biological field. The main crystal phase of the material is the hydroxylapatite which is doped with the rare earth samarium. The hydroxylapatite fluorescent material is prepared by performing hydrothermal treatment to a hydrothermal precursor solution having certain concentration ratio and being regulated to certain pH value under a sealed hydrothermal condition.

Description

technical field [0001] The invention relates to a preparation method of a fluorescent material, in particular to a preparation method of a rare earth samarium-doped hydroxyapatite fluorescent material. Background technique [0002] With the development of life sciences, people hope to obtain rich and detailed intuitive information about tissues, cells, etc., prompting the rapid development of various imaging technologies. Among them, bioluminescent imaging has always been the focus of attention due to its advantages of less destructive, high sensitivity, and good selectivity. However, the development of fluorescence imaging is restricted by the performance of fluorescent probes. Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HAp) have excellent biocompatibility, osteoinductivity, non-immunogenicity, degradability and other properties, and are widely used in tissue engineering, drug and gene delivery and other biological fields. At the same time, hydroxyapatite is also a goo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/71
CPCC09K11/7759
Inventor 乔荫颇张攀周沁殷海荣刘晶李艳肖
Owner SHAANXI UNIV OF SCI & TECH
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