A core-shell multifunctional nanomaterial and preparation method thereof
A technology of nanomaterials and nanoluminescent materials, which is applied in the field of core-shell multifunctional nanomaterials and their preparation, can solve problems such as detection interference, and achieve the effect of CT imaging and photothermal therapy
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Embodiment 1
[0049] 1) Synthesis of up-conversion nano-luminescent materials: Mix 2g NaOH, 7mL distilled water, 12mL ethanol, and 20mL oleic acid, stir magnetically to form a transparent solution, then add 0.0775g YbCl 3 ·6H 2 O, 0.2367g YCl 3 ·6H 2 O and 0.00541 g ErCl 3 2mL of rare earth compound aqueous solution (78%Y, 20%Yb, 2%Er) 2mL, add 0.1g of surfactant, stir well. Add 5mL of 1mol / L NaF solution dropwise, stir for 10min, transfer to a 50mL reactor, react at 200°C for 15h, and naturally cool to room temperature in an oven. Take it out, dissolve and collect it with cyclohexane, then add ethanol to precipitate the sample, centrifuge at 8000rpm / min for 10min, wash the obtained precipitate with ethanol and distilled water for 2-3 times, and finally dry it in a vacuum oven at 90°C for 4h to obtain Up-conversion nanoluminescent materials. The morphology of the up-conversion nanoluminescent material obtained by SEM is as follows: figure 1 , figure 2 , image 3 and Figure 4 show...
Embodiment 2
[0057] The upconversion nanomaterials are synthesized by hydrothermal synthesis method, and the specific process is as follows: (1) preparation of rare earth chloride aqueous solution. 2mL rare earth chloride (0.5mol / L LnCl 3 , Ln is 78%Y+20%Yb+2%Er (mole fraction)) aqueous solution was added to 20 mL of ethylene glycol, 16-alkyl sodium sulfonate was added, stirred evenly, and solution A was obtained after 10 minutes. The specific weighing data are as follows: YbCl 3 : 0.07611g, YCl 3 0.23551g, ErCl 3 0.00551g (2) Configuration of NaF solution: Weigh 0.18900g NaF, add 4.5mL water, and configure it as a 1.0 mol / L aqueous solution. Add the compounded solution into 20 mL of ethylene glycol, stir well, and obtain solution B after 10 minutes. (3) Mix A and B solutions. Pour solution B into solution A quickly, and stir the mixed solution quickly with a glass plate for about 10 min. (4) After stirring evenly, transfer the prepared solution to a 100mL reactor, seal it and put ...
Embodiment 3
[0061] Add 200 mg of solid powder coated with gold nanoparticles into a 5mL centrifuge tube, and then add 500 μL of 0.1 mol / LMnCl 2 solution, and then add 1mL 0.1mol / L Na dropwise under stirring condition 2 CO 3 solution, centrifuged after 30min, washed with deionized water, and removed the supernatant to obtain MnCO 3 It is an up-conversion nano-luminescent material for the shell.
[0062] in MnCO 3 Surface marker antibodies.
[0063] In summary, a core-shell type multifunctional nanomaterial and its preparation method according to the present invention, the core of the core-shell type multifunctional nanomaterial is an up-conversion nano-luminescent material, the shell is an alkaline manganese compound, and the core Nano-gold particles are also deposited between the shell and the shell. The core-shell multifunctional nanomaterial of the invention can simultaneously realize fluorescence detection and magnetic resonance imaging analysis. The core material is a rare earth...
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