Chitin scar-restraint gel coating as well as preparation method and application thereof

Abstract

The invention discloses a chitin scar-suppressing gel coating agent and its preparation method and application. The coating agent is composed of the following raw materials according to mass percentage: 0.5%-4.5% of the scar-suppressing agent, 1.0%-3.5% of the penetrating agent %, polyvinyl alcohol 4.2%-6.5%, ethanol 5.0%-10.5%, and the balance is purified water. Dissolving the scar inhibitor in 20.0% ethanol aqueous solution; wherein the 20.0% ethanol aqueous solution is prepared by ethanol into an ethanol aqueous solution with a mass content of 20.0%; at a temperature of 80°C-90°C, dissolve polyvinyl alcohol in purified water; Mix the materials prepared above, add penetrating agent, mix evenly, vacuumize and fill. The coating agent prepared by the present invention is applied to the wound and the edge after debridement to a certain thickness, and the gel coating agent quickly forms a layer of film, which can effectively protect the wound surface, and is suitable for burns, scalds, mosquito bites and other skin damages, etc. The protection of body surface wounds has the effects of antibacterial, anti-inflammatory, analgesic, and inhibition of scar hyperplasia.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a chitin scar-suppressing gel coating agent and its preparation method and application. Background technique [0002] With the arrival of summer, accidental injuries such as mosquito bites and burns increase, and similar body surface wounds are prone to infection, causing the formation of wound scars and the deposition of melanin. The scars on the body surface also affect the beauty of the patient's skin and cause great harm to the patient's heart. Therefore, it is particularly important to protect body surface wounds such as burns, scalds, and skin damage. There are various medicines for treating scars on the market, but they are not effective and prone to allergies. [0003] Invention patent CN1219521C provides an external medicament capable of inhibiting and treating acne and the scars left by acne and its preparation method, and patent CN1064237C provides a scar inhibitor ...

AI Technical Summary

Problems solved by technology

[0004] Invention patent CN104257639 B discloses a coating agent for wound treatment and its preparation method, including chitosan, film-forming material, plasticizer and solvent, which contains parabens, sodium benzoate or benzalkonate Preservatives such as ammonium bromide are harmful to the human body. The film-forming time of the coating agent is 5 minutes to 30 minutes, and the film-forming speed is relatively slow.

[0005] In the invention patent CN1034465078, it mainly provides a traditional Chinese medicine ointment formula for anti-inflammatory, analgesic, and scar suppression, which is beneficial to the rapid growth of epithelial tissue and accelerated skin tightening.

At present, there is no report of adding chitin anti-scar ingredients into wound coatings. In view of the inhibition of scar hyperplasia of chitosan and the good film-forming properties of polyvinyl alcohol, the combination of the two can simultaneously achieve wound protection and scar hyperplasia inhibition. effect