Apixaban tablet

A technology of apixaban tablets and fillers, applied in the field of pharmaceutical preparations, can solve the problems of easy sticking, complicated process, poor surface finish of tablets, etc., and achieve the effect of fast dissolution rate and simple process

Active Publication Date: 2016-10-05
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Foreign countries adopt the dry granulation process after micronization of raw materials, although it has been improved to a certain extent, but the dry granulation process is complicated, the dust production is large, and the particle size is not uniform, and the surface finish of the pressed tablet is poor.
[0005] CN10290832...

Method used

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  • Apixaban tablet
  • Apixaban tablet
  • Apixaban tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] prescription:

[0023]

[0024] Preparation Process:

[0025] Dissolve apixaban in diethylene glycol monoethyl ether, add hydroxypropyl cellulose, stir to dissolve, then add the prescribed amount of fumed silica for adsorption, and then mix with lactose, sodium carboxymethyl starch, stearin Magnesium acid is mixed evenly and compressed by direct compression technology.

Embodiment 2

[0027] prescription:

[0028]

[0029] Preparation Process:

[0030] Dissolve apixaban in diethylene glycol monoethyl ether, add hydroxypropyl cellulose, stir to dissolve, add the prescribed amount of fumed silica for adsorption, and then mix with microcrystalline cellulose and crospovidone , Magnesium stearate mixed uniformly, compressed by direct compression process.

Embodiment 3

[0032] prescription:

[0033]

[0034] Preparation Process:

[0035] Dissolve apixaban in diethylene glycol monoethyl ether, add hydroxypropyl cellulose, stir to dissolve, add the prescribed amount of fumed silica for adsorption, and then mix with microcrystalline cellulose and crospovidone , Magnesium stearate mixed uniformly, compressed by direct compression process.

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PUM

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to an apixaban tablet. The apixaban tablet contains apixaban, hydroxy propyl cellulose and fumed silica. A preparation method of the apixaban tablet comprises the following steps: dissolving apixaban and hydroxy propyl cellulose in diethylene glycol monoethyl ether, adding with fumed silica for adsorption, then uniformly mixing with pharmaceutically acceptable auxiliary materials, and carrying out pressing by adopting a direct tableting technology. Compared with the prior art, the apixaban tablet has the advantages that the medicine dissolution speed is high, the process is simple, a surfactant does not need to be added, and the micronization treatment is not needed. The acceleration test result shows that the prepared apixaban tablet is good in stability.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to an apixaban tablet. Background technique [0002] Apixaban is a novel oral direct factor Xa inhibitor that activates coagulation factor Xa (whose main practical role is to generate thrombin through restricted proteolysis of prothrombin) in the final common pathway of coagulation in connection with endogenous The important position of sex and exogenous activation mechanism. Thrombin (the final serine protease in the pathway to produce a fibrin clot from its precursor) is produced by the formation of the prothrombin enzyme complex (coagulation factor Xa, coagulation factor V, Ca 2+ and phospholipids) are amplified. Since one factor Xa molecule was calculated to generate 138 thrombin-inhibiting molecules, factor Xa may be more effective in interrupting the coagulation system than inactivation of thrombin. Thus, factor Xa inhibitors are a class of compounds tha...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4545A61K47/38A61P7/02
Inventor 张贵民郝贵周高西蒙
Owner SHANDONG NEWTIME PHARMA
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