Preparation method and application of nanometer sustained release sodium butyrate for feed of grass carp

A technology for slow-release sodium butyrate and grass carp feed is applied in the molding or processing, application, animal feed and other directions of animal feed, which can solve the problems of non-sustainability, unsatisfactory dissolution and release effect, and immature technology. Easy to implement, improve absorption, increase the effect of breeding production

Active Publication Date: 2016-10-12
CHANGSHA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the sodium butyrate coating technology mainly uses different types of coating materials to coat sodium butyrate, so as to protect butyrate from being absorbed in the stomach as much as possible, but the current technology is not yet mature, and the dissolution in intestinal juice The release effect is not ideal, and it is not sustainable

Method used

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  • Preparation method and application of nanometer sustained release sodium butyrate for feed of grass carp
  • Preparation method and application of nanometer sustained release sodium butyrate for feed of grass carp
  • Preparation method and application of nanometer sustained release sodium butyrate for feed of grass carp

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Embodiment 1

[0021] Embodiment 1: use nano slow-release sodium butyrate for grass carp feed of the present invention, adopt following technical process to carry out grass carp indoor cultivation, obtain better effect.

[0022] (1) Weigh 40g of sodium hydroxide, dissolve it in 1000ml of water, add 40g of n-butyric acid evenly dropwise, react for 2.0 hours after the dropwise addition, add 150g of auxiliary materials, and spray dry at 220°C to obtain nano-sustained-release sodium butyrate.

[0023] (2) The excipients consist of 2 parts of beeswax, 2 parts of palm wax, 0.3 parts of fish oil, 4 parts of polyethylene glycol, 0.8 parts of filler, and 1.5 parts of nano sustained-release carrier.

[0024] (3) Wherein the preparation method of the nano-sustained-release carrier is: weigh 2.0054g dry polyethylene glycol 4000, add 3.00mL polycaprolactone and 0.2mL stannous octoate, cool in liquid nitrogen, vacuumize, and pass nitrogen gas Oxygen was exhausted, and the reaction was stirred at 135°C for...

Embodiment 2

[0029] Embodiment 2: use the nano slow-release sodium butyrate for grass carp feed of the present invention, adopt the following technical process to carry out grass carp cage culture, and obtain better results.

[0030] (1) Weigh 40g of sodium hydroxide, dissolve it in 1000ml of water, add 60g of n-butyric acid evenly dropwise, react for 2.0 hours after the dropwise addition, add 200g of excipients, and spray dry at 220°C to obtain nano-sustained-release sodium butyrate.

[0031] (2) The excipients consist of 2.5 parts of beeswax, 1.5 parts of palm wax, 0.5 parts of fish oil, 3 parts of polyethylene glycol, 1 part of filler, and 1.5 parts of nano sustained-release carrier.

[0032] (3) Wherein the preparation method of the nano-sustained-release carrier is: weigh 2.0054g dry polyethylene glycol 4000, add 3.00mL polycaprolactone and 0.2mL stannous octoate, cool in liquid nitrogen, vacuumize, and pass nitrogen gas Oxygen was exhausted, and the reaction was stirred at 135°C for ...

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Abstract

The invention discloses a preparation method of nanometer sustained release sodium butyrate for feed of grass carp and relates to the technical field of fish feed. The preparation method comprises the following steps: n-butyric acid is added dropwise uniformly to a sodium hydroxide solution, a reaction is performed for 1.5-2.0 h after addition, and a sodium butyrate solution is obtained; auxiliaries comprising 2-3 parts of beewax, 1-2 parts of palm wax, 0.1-0.5 parts of fish oil, 1-4 parts of polyethylene glycol, 0.5-1 part of filler and 1-1.5 parts of a nanometer sustained release carrier are added to the sodium butyrate solution in a mass ratio of the auxiliaries to the sodium butyrate solution being (1-1.5):2; finally, nanometer sustained release sodium butyrate is obtained through spray drying at the temperature of 200-220 DEG C. Nano-embedding is performed on sodium butyrate with a nano-embedding technology, so that the defects that sodium butyrate has odor, is prone to deliquescence, difficult to be used by intestinal tracts and cannot provide energy for the intestinal tracts continuously are overcome; intestinal health of the grass carp is promoted, absorption of nutrients is improved, and the economic benefit for breeding the grass carp is increased.

Description

Technical field: [0001] The invention relates to a preparation method and application of nano slow-release sodium butyrate for grass carp feed, belonging to the technical field of fish feed. Background technique: [0002] Sodium butyrate can improve the shape of the small intestine, promote the proliferation and maturation of intestinal cells, maintain the normal shape of intestinal epithelial cells, promote digestion and absorption of the small intestine, accelerate the growth rate of grass carp, and improve the production performance of grass carp. [0003] Sodium butyrate is the short-chain volatile fatty acid butyrate, which is the preferred energy source of intestinal cells. Ordinary sodium butyrate is mostly absorbed in the crop or stomach, and only a small part reaches the intestinal tract. At the same time, the gastric acid environment also has a greater impact on sodium butyrate, so ordinary sodium butyrate cannot meet the requirements of each segment of the intesti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K50/80A23K20/105A23K10/20A23K10/30A23K20/158A23K40/30
Inventor 唐建洲彭亮刘臻李晓洁曾丹丹彭翠婷伍守花
Owner CHANGSHA UNIVERSITY
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