Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of baicalein and derivative 6,7-diacetyl radix scutellariae thereof

A technology of diacetyl baicalein and its derivatives, which is applied in the direction of medical preparations containing active ingredients, drug combinations, and pharmaceutical formulas, etc., to achieve the effect of improving bioavailability

Inactive Publication Date: 2016-10-12
PEKING UNIV
View PDF2 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, oral administration of baicalein has a wide range of hepatic and intestinal first-pass effects, mainly manifested in the glucuronidation and sulfation metabolic reactions of phase II metabolism

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of baicalein and derivative 6,7-diacetyl radix scutellariae thereof
  • Application of baicalein and derivative 6,7-diacetyl radix scutellariae thereof
  • Application of baicalein and derivative 6,7-diacetyl radix scutellariae thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1. Pharmacodynamic test of 6,7-diacetylbaicalein in preventing and treating hyperuricemia and the kidney damage caused by it

[0037] 1. Computer simulation predicts the combination of XOR and baicalein

[0038] Software: SYBYL 6.92, Chimera, Microsoft Excel, database: Protein Data Bank. Download the three-dimensional structure of the protein Xanthine Dehydrogenase from Bovine Milk with InhibitorTEI-6720Bound (PDB ID: 1N5X) from the PDB database (which contains the structure of the original ligand TEI). The ligand and receptor were split with Chimera and the receptor protein was saved as a file in PDB format. Use SYBYL software to draw the ligand TEI structure and save it in mol2 format. Put the 2 pdb and 1 mol2 files into a new folder for later use. Open the SYBYL software, import the 1N5X.pdb file (including meta-ligands), delete the B chain, and leave only the A chain as the docking material. Select the natural ligand TEI, and generate an active site pock...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of baicalein and a derivative 6,7-diacetyl radix scutellariae thereof to preparation of medicine for treating hyperuricemia and / or preparation of medicine for treating renal injury caused by hyperuricemia. The baicalein and the derivative 6,7-diacetyl radix scutellariae thereof can remarkably lower the uric acid level, the creatinine level and the urea nitrogen level of hyperuricemia , and the 6,7-diacetyl radix scutellariae has a remarkable protection function on the kidney. The baicalein has a first-pass effect of liver sausage, the derivative 6,7-diacetyl radix scutellariae of the baicalein can inhibit the first-pass effect of liver sausage, and bioavailability is improved.

Description

technical field [0001] The present invention relates to the use of baicalein and its derivative 6,7-diacetylbaicalein. Background technique [0002] 1. General characteristics of baicalein and its derivative 6,7-diacetylbaicalein [0003] The structural formula of baicalein is shown in formula I: [0004] [0005] Traditional medicine Scutellaria baicalensis is the dry root of Lamiaceae plant Scutellaria baicalensis Georgi. "The Pharmacopoeia of the People's Republic of China" records that Scutellaria baicalensis has the effects of "clearing away heat and dampness, purging fire and detoxification, stopping bleeding, and preventing miscarriage", and is one of the commonly used drugs in traditional Chinese medicine. Baicalein is one of the flavonoids with the highest content in Scutellaria baicalensis. Its chemical name is 5,6,7-trihydroxyflavone. The National Pharmacopoeia Committee officially named it baicalein (English name is baicalein). Studies have shown that after...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P19/06A61P13/12
CPCA61K31/352
Inventor 周虹杨宝学孟晓璐
Owner PEKING UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com