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Synthesis method of N,N-diisopropyl-2-isopropoxy ethylamine

A technology of isopropoxyethylamine and diisopropyl, applied in the field of organic compound preparation, can solve the problems of complex process, high price, unsuitable for industrial production, etc. Effect

Inactive Publication Date: 2016-10-12
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] For the target compound of the present invention, the corresponding raw material is diisopropylethyl chloride ethylamine, which is obtained by chlorination of diisopropylethanolamine, the process is complex, the price is high, and it is not suitable for industrial production

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  • Synthesis method of N,N-diisopropyl-2-isopropoxy ethylamine
  • Synthesis method of N,N-diisopropyl-2-isopropoxy ethylamine
  • Synthesis method of N,N-diisopropyl-2-isopropoxy ethylamine

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Embodiment 1

[0033] Embodiment 1, a kind of synthetic method of N,N-diisopropyl-2-isopropoxyethylamine,

[0034] Add 0.2 mol of diisopropylamine, 1.0 mol of 1,2-dichloroethane, 1.0 mol of isopropanol, and 0.3 mol of anhydrous sodium carbonate solid into the autoclave. Then close the lid of the kettle, start stirring after leak detection, heat to 180°C, and the pressure is 1.5MPa. The reaction was continued for 7 hours with no change in pressure during the process. Stop heating after the reaction time is up, stop stirring after cooling, open the kettle, pour out the reaction solution, add saturated sodium hydroxide solution, adjust the pH to 10-12, neutralize the hydrochloride in the product, and obtain an oil layer containing the target product (located in the upper layer), rectification (batch rectification under normal pressure, collecting fractions at 210-214° C.) to obtain the target product with a yield of 92.47%.

[0035] Embodiment 2-Embodiment 7, change the process parameters in ...

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Abstract

The invention discloses a synthesis method of N,N-diisopropyl-2-isopropoxy ethylamine; with diisopropylamine, 1,2-dichloroethane and isopropanol as raw materials and sodium carbonate as an acid binding agent, a reaction is completed in an autoclave with the reaction temperature of 120-180 DEG C, the reaction pressure of 0.5-1.5 MPa and the reaction time of 3-7 h; the molar ratio of diisopropylamine to 1,2-dichloroethane is 1 to (2-10), and the molar ratio of 1,2-dichloroethane to isopropanol is 1 to 1; the pH of the obtained reaction liquid is adjusted to be alkaline with an alkali liquor, the reaction liquid is stratified to obtain an oil phase, and the oil phase is rectified to obtain N,N-diisopropyl-2-isopropoxy ethylamine.

Description

technical field [0001] The invention belongs to the field of organic compound preparation, and relates to a preparation method of N,N-dialkyl-2-alkoxyethylamine, specifically a kind of N,N-diisopropyl-2-isopropoxyethylamine Amine (namely: N-(1-methylethyl)-N-[2-(1-methylethoxy)ethyl]-2-propylamine) preparation method. Background technique [0002] N,N-Diisopropyl-2-isopropoxyethylamine, 2-Propanamine, N-[2-(1-methylethoxy)ethyl]-N-(1-methylethyl)-, is an alkoxy Substituted tertiary amine derivatives having the formula C 11 h 25 NO, the molecular weight is 187.19, and its structural formula is shown in S-1. N,N-Diisopropyl-2-isopropoxyethylamine can be used as an acid-binding agent to play a key role in some reactions. At the same time, due to the large steric hindrance near the nitrogen atom of the compound, the nucleophilic ability is poor, so that the occurrence of side reactions can be avoided when used as an acid-binding agent. At present, there is no literature rep...

Claims

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Application Information

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IPC IPC(8): C07C213/00C07C213/10C07C217/08
CPCC07C213/00C07C213/10C07C217/08
Inventor 钱超刘豆陈新志
Owner ZHEJIANG UNIV
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