Magnetic fluorescent difunctional nano material based on natural polymer and preparation method thereof

A technology of natural polymers and nanomaterials, applied in luminescent materials, nanotechnology for materials and surface science, and magnetism of organic materials/organic magnetic materials, etc., can solve the problem of poor biocompatibility of magnetic fluorescent nanomaterials, magnetic fluorescence The application of nanomaterials is limited, the preparation process is complicated and difficult, etc., to achieve good biocompatibility and degradability, renewable raw material sources, and good biocompatibility.

Active Publication Date: 2014-01-22
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The purpose of the present invention is to solve the problem that the application of magnetic fluorescent nanomaterials in the field of biomedicine is limited due to the poor biocompatibility, refractory degradation, and complica

Method used

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  • Magnetic fluorescent difunctional nano material based on natural polymer and preparation method thereof
  • Magnetic fluorescent difunctional nano material based on natural polymer and preparation method thereof
  • Magnetic fluorescent difunctional nano material based on natural polymer and preparation method thereof

Examples

Experimental program
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Example Embodiment

[0039] Example 1:

[0040] The magnetic fluorescent dual-function nanomaterial based on natural polymer and its preparation method, the specific steps are as follows:

[0041] 1) Magnetic fluid nano Fe 3 O 4 Synthesis

[0042] Using co-precipitation method, weigh out 1.5g FeCl 3 ·6H 2 O, 0.6gFeSO 4 ·4H 2 O, dissolved in deionized water degassed by nitrogen beforehand, and pass N 2 Protect, heat to 70℃, then quickly stir and slowly add 5ml ammonia water. After reacting for 1 hour, the resulting precipitate was separated from the reaction medium by an external magnetic field, and washed three times with secondary water to obtain nano-Fe 3 O 4 Suspension, ultrasonic 15min, the black solution obtained is nano Fe 3 O 4 Magnetic fluid.

[0043] 2) Chitosan-Fe 3 O 4 Preparation of nanospheres

[0044] Take 0.15gFe 3 O 4 The magnetic fluid was mixed with 20 mL of 7.5 mg / mL chitosan (CS) acetic acid solution, and ultrasonically dispersed for 20 minutes. Under stirring, slowly add to the mixtur...

Example Embodiment

[0050] Example 2:

[0051] The magnetic fluorescent dual-function nanomaterial based on natural polymer and its preparation method, the specific steps are as follows:

[0052] 1) Magnetic fluid nano Fe 3 O 4 Synthesis

[0053] Using co-precipitation method, weigh 1.3g FeCl 3 ·6H 2 O, 0.5gFeSO 4 ·4H 2 O, dissolved in deionized water degassed by nitrogen beforehand, and pass N 2 Protect, heat to 69°C, then quickly stir and slowly add 6mL ammonia. After reacting for 1 hour, the resulting precipitate was separated from the reaction medium by an external magnetic field, and washed three times with secondary water to obtain nano-Fe 3 O 4 Suspension, ultrasonic for 20min, the black solution obtained is nano Fe 3 O 4 Magnetic fluid.

[0054] 2) Chitosan-Fe 3 O 4 Preparation of nanospheres

[0055] Take 0.15gFe 3 O 4 The magnetic fluid was mixed with 12 mL of 12 mg / mL chitosan (CS) acetic acid solution, and ultrasonically dispersed for 15 minutes. Under stirring, slowly add to the mixture of 5...

Example Embodiment

[0061] Example 3:

[0062] The magnetic fluorescent dual-function nanomaterial based on natural polymer and its preparation method, the specific steps are as follows:

[0063] 1) Magnetic fluid nano Fe 3 O 4 Synthesis

[0064] Using the co-precipitation method, weigh 1.4g FeCl 3 ·6H 2 O, 0.5gFeSO 4 ·4H 2 O, dissolved in deionized water degassed by nitrogen beforehand, and pass N 2 Protect, heat to 70℃, then quickly stir and slowly add 6ml ammonia water. After reacting for 1.5h, the resulting precipitate was separated from the reaction medium by an external magnetic field, and washed three times with secondary water to obtain nano-Fe 3 O 4 Suspension, ultrasonic for 25min, the black solution obtained is nano Fe 3 O 4 Magnetic fluid.

[0065] 2) Chitosan-Fe 3 O 4 Preparation of nanospheres

[0066] Take 0.13gFe 3 O 4 The magnetic fluid was mixed with 24 mL of 5 mg / mL chitosan (CS) acetic acid solution, and ultrasonically dispersed for 20 minutes. Under stirring, slowly add to the mixtur...

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Abstract

The invention relates to a multifunctional nano composite material of a core-shell structure and in particular relates to a carbon quantum dot magnetic fluorescent difunctional nano material and a preparation method thereof. Magnetic particle Fe3O is taken as a core, chitosan and polyanionic-based cellulose are taken as shell material, a carbon quantum dot is taken as a fluorescent material, and the carbon quantum dot magnetic fluorescent difunctional nano material is obtained by adopting a layer-by-layer self-assembly method; the carbon quantum dot is coated by adopting a natural polymer material, so that no free carbon quantum dot is formed, and stability is improved; magnetic property and fluorescence strength can be regulated and controlled by virtue of number of layers of the shell material and the addition amount of the carbon quantum dot; the obtained magnetic fluorescent difunctional nano material has a broad application prospect in the biological medicine fields of cell marking and absorption, bioimaging, medicine detection and disease diagnosis, medicine carrying and the like.

Description

technical field [0001] The invention relates to a multifunctional nanocomposite material with a core-shell structure, in particular to a magnetic fluorescent bifunctional nanomaterial based on a natural polymer and a preparation method thereof, belonging to the field of material technology. Background technique [0002] Magnetic nanoparticles have attracted more and more attention in biomedicine because of their magnetic properties and nanoscale properties. In order to improve the efficiency of magnetic nanoparticles in cell labeling and absorption, bioimaging, drug detection and disease diagnosis, it is very important and urgent to endow magnetic nanoparticles with multiple functions, especially the combination of magnetic and optical properties. Magnetic-fluorescent composites have emerged as important tools for in vivo imaging, either monitored by magnetic resonance imaging or imaged optically by fluorescence. [0003] There are usually two methods for the combination of...

Claims

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Application Information

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IPC IPC(8): C09K11/06H01F1/42B82Y30/00B82Y40/00B82Y20/00B82Y25/00
Inventor 王飞俊李佳邵自强
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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