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Preparation method of ginsenoside transdermal agent

A technology of ginsenosides and transdermal agents is applied in the field of preparation of transdermal agents, which can solve the problems of inconvenient clinical administration of liquid preparations, restricted utilization and the like, and achieve the effects of improving immunity of the body, relieving local symptoms and simple operation.

Inactive Publication Date: 2016-10-19
TIANJIN PHARMACN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when it is used as a topical preparation, it is often limited due to the inconvenience of clinical administration of liquid preparations.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A ginsenoside transdermal agent mainly contains ginsenoside, and the encapsulation rate is 86.79±1.68%.

[0029] The preparation method of above-mentioned a kind of ginsenoside transdermal agent, concrete preparation steps are as follows:

[0030] (1) Ginsenosides are ultrafinely pulverized and passed through a 200-mesh sieve;

[0031] (2) Taking ginsenoside 25g as raw material;

[0032] (3) Add ginsenosides to 1L of absolute ethanol, and stir magnetically for 6 hours at room temperature in a closed explosion-proof environment;

[0033] (4) Put the solution obtained in step (3) into distilled water with V / V of 16:1, stir for 30min, and set aside;

[0034] (5) Dissolve 1g of chitosan in 32mL of 1% glacial acetic acid solution, stir and dissolve to obtain chitosan glacial acetic acid solution, wherein the stirring temperature is 45-55°C, and the heating method is steam heating;

[0035] (6) Dissolving 32mL of Chinese medicinal extract A in step (5) oligochitosaccharide...

Embodiment 2

[0044] A ginsenoside transdermal agent mainly contains ginsenoside, and the encapsulation rate is 84.89±1.79%.

[0045] The preparation method of above-mentioned a kind of ginsenoside transdermal agent, concrete preparation steps are as follows:

[0046] (1) Ginsenosides are ultrafinely pulverized and passed through a 300-mesh sieve;

[0047] (2) taking ginsenoside 30g as raw material;

[0048] (3) Add ginsenosides to 1L of absolute ethanol, and stir magnetically for 6 hours at room temperature in a closed explosion-proof environment;

[0049] (4) Put the solution obtained in step (3) into distilled water with V / V of 16:1, stir for 30min, and set aside;

[0050] (5) Dissolve 7.5g of chitosan in 160mL of 2% glacial acetic acid, stir and dissolve to obtain chitosan glacial acetic acid solution, the stirring temperature is 45, and the heating method is steam heating.

[0051] (6) Dissolve 160 mL of Chinese medicine extract A in step (5) chitooligosaccharide glacial acetic acid...

Embodiment 3

[0060] A ginsenoside transdermal agent mainly contains ginsenoside, and the encapsulation rate is 81.89±1.33%.

[0061] The preparation method of above-mentioned a kind of ginsenoside transdermal agent, concrete preparation steps are as follows:

[0062] (1) Ginsenosides are ultrafinely pulverized and passed through a 100-mesh sieve;

[0063] (2) Taking ginsenoside 28g as raw material;

[0064] (3) Add ginsenosides to 1L of absolute ethanol, and stir magnetically for 6 hours at room temperature in a closed explosion-proof environment;

[0065] (4) Put the solution obtained in step (3) into distilled water with V / V of 16:1, stir for 30min, and set aside;

[0066] (5) Dissolve 1.8g of chitosan in 32mL of 3% glacial acetic acid, stir and dissolve to obtain a chitosan glacial acetic acid solution, the stirring temperature is 55°C, and the heating method is steam heating.

[0067] (6) Dissolve 64mL of Chinese medicine extract A in step (5) chitooligosaccharide glacial acetic aci...

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Abstract

The invention relates to a preparation method of a ginsenoside transdermal agent. The method comprises the following steps: (1) dissolved ginsenoside in ethanol and distilled water; (2) heating to prepare a chitosan acetic acid solution; (3) mixing a Chinese herbal extract with the chitosan acetic acid solution; (4) adding the mixture to an emulsification system for emulsification; (5) subjecting the emulsification products to a cross-linking reaction; and (6) treating the crosslinking products by washing, precipitation, centrifugation and drying to obtain a transdermal drug membrane containing Chinese herbal extract. The preparation method is simple, and applicable to large-scale industrial production.

Description

technical field [0001] The invention relates to a preparation method of a transdermal agent, in particular to a preparation method of a ginsenoside transdermal agent. Background technique [0002] Ginsenoside is the main active alkaloid in traditional Chinese medicine ginseng. Modern medical research shows that ginsenoside has various functions such as dilating blood vessels, preventing thrombosis, inhibiting platelet aggregation, and improving cerebral ischemia. The treatment of vascular diseases and achieve a relatively ideal therapeutic effect, according to the results of pharmacokinetic studies, ginsenosides have the characteristics of fast absorption, fast metabolism, and short half-life (2.8 hours), so when administered orally or intramuscularly, it is required Frequent administration can maintain the effective blood concentration of the drug, so it is necessary to develop its long-acting preparation. [0003] The transdermal agent is a space network water-filled cros...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K36/258A61K31/704A61K47/36A61P9/14A61P1/16A61P31/14A61P31/20A61P35/00A61P37/02A61P31/04
Inventor 田东奎何磊
Owner TIANJIN PHARMACN MEDICAL TECH
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