Ultrasonic coupling agent for medical ultrasonic diagnosis and therapy and preparation method thereof

An ultrasonic coupling agent and ultrasonic technology, applied in the direction of echo/ultrasonic imaging agent, local antibacterial agent, etc., can solve the problems of large sound attenuation coefficient and low sound attenuation coefficient, and achieve small attenuation coefficient, easy cleaning and wide application range Effect

Inactive Publication Date: 2016-11-09
QINGDAO YUNTIAN BIOTECH
View PDF3 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the defect that the existing bactericidal ultrasonic coupling agent has an excessively large sound attenuation coefficient, and provide an ultrasonic coupling agent for medical ultrasonic diagnosis and treatment and a preparation method thereof. The ultrasonic coupling agent has an extremely low acoustic attenuation coefficient and Strong antibacterial performance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ultrasonic coupling agent for medical ultrasonic diagnosis and therapy and preparation method thereof
  • Ultrasonic coupling agent for medical ultrasonic diagnosis and therapy and preparation method thereof
  • Ultrasonic coupling agent for medical ultrasonic diagnosis and therapy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0019] The preparation method of the chitin morpholine quaternary ammonium salt is as follows: under nitrogen protection, 100g chitin, 135.6g methylglycidyl morpholine quaternary ammonium salt, and 51.4g sodium hydroxide are added to DMSO at 35°C for reaction After 12 hours, cool to room temperature, adjust the pH to 6-7 with hydrochloric acid, concentrate the reaction solution, and recrystallize from methanol to obtain chitin morpholine quaternary ammonium salt. 1 HNMR (DMSO, d6) 1.95(s, 3H), 3.18(s, 3H), 3.31(s, 3H), 3.45(m, 4H), 3.51~3.60(m, 11H), 4.37~4.53(m, 5H) ), 4.75 (s, br, 1H), 5.22 (s, br, 1H), 7.92 (s, 1H).

preparation example 2

[0021] The preparation method of the chitin morpholine quaternary ammonium salt is as follows: under the protection of nitrogen, 100g chitin, 101.7g methylglycidyl morpholine quaternary ammonium salt, and 34.3g sodium hydroxide are added to DMSO at 45°C for reaction After 12 hours, cool to room temperature, adjust the pH to 6-7 with hydrochloric acid, concentrate the reaction solution, and recrystallize from methanol to obtain chitin morpholine quaternary ammonium salt. 1 HNMR (DMSO, d6) 1.95(s, 3H), 3.19(s, 3H), 3.31(s, 3H), 3.45(m, 4H), 3.53~3.60(m, 11H), 4.37~4.53(m, 5H) ), 4.78 (s, br, 1H), 5.23 (s, br, 1H), 7.92 (s, 1H).

preparation example 3

[0023] The preparation method of the chitin morpholine quaternary ammonium salt is as follows: under nitrogen protection, 100g chitin, 99.6g trimethylglycidyl quaternary ammonium salt, 68.6g sodium hydroxide are added to DMSO at 35°C for 12 hours, cooled to room temperature, adjusted the pH to 6-7 with hydrochloric acid, concentrated the reaction solution, and recrystallized from methanol to obtain chitin morpholine quaternary ammonium salt. 1 HNMR (DMSO, d6) 1.95(s, 3H), 3.20(s, 7H), 3.31(s, 3H), 3.51~3.60(m, 6H), 4.37~4.53(m, 4H), 4.75(s, br , 1H), 5.22 (s, br, 1H), 7.92 (s, 1H).

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
lengthaaaaaaaaaa
Login to view more

Abstract

The invention discloses an ultrasonic coupling agent for medical ultrasonic diagnosis and therapy and a preparation method thereof. The ultrasonic coupling agent is prepared from the following components: chitin morpholine quaternary ammonium salt, polyethylene glycol, glycerol, triethanolamine and the balance of water, wherein the chitin morpholine quaternary ammonium salt is a product of a reaction of chitin and methyl epoxypropyl morpholine quaternary ammonium salt. The ultrasonic coupling agent for the medical ultrasonic diagnosis and therapy, disclosed by the invention, has strong sterilization effect and extremely small sound attenuation property.

Description

technical field [0001] The invention relates to an ultrasonic coupling agent for medical ultrasonic diagnosis and treatment and a preparation method thereof. Background technique [0002] At present, ultrasonic coupling agent is generally used as a medium in medical ultrasonic diagnosis and treatment, which is used to strengthen the coupling between the ultrasonic probe and human skin and to isolate the air between the ultrasonic probe and the skin of the examined part, so as to reduce the attenuation during the sound wave transmission process, so as to obtain Accurate inspection results. Therefore, the clarity and resolution of ultrasound diagnosis and treatment images are not only related to the equipment, but also closely related to the quality of the ultrasound gel, especially the sound attenuation coefficient of the ultrasound gel. [0003] In ultrasound diagnosis and treatment, since the ultrasound probe is in contact with the subject's body skin or mucous membrane of...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K31/722A61P31/02
CPCA61K49/22A61K31/722
Inventor 王传秀史维倩郑宇然
Owner QINGDAO YUNTIAN BIOTECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap