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A kind of method for preparing glycolic acid

A glycolic acid and ethanol technology, applied in the field of glycolic acid preparation, can solve the problems of product separation, complex refining, high equipment requirements, low raw material cost, etc., and achieve the effect of being conducive to environmental protection and resource utilization

Active Publication Date: 2019-01-25
SHANDONG GUOBANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The yield of glycolic acid is nearly 90% at 90MPa. This method has low cost of raw materials, but requires high equipment, and the separation and purification of products are complicated.
[0006] N,N-diethyl-2,3,3,3-tetrafluoropropionamide is a by-product of the new broad-spectrum antibacterial veterinary drug fluthiamphenicol. It is treated as waste liquid in industry, and there is no resource utilization of it at present. to report

Method used

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  • A kind of method for preparing glycolic acid

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Experimental program
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Effect test

Embodiment 1

[0029] Put 140g of N,N-diethyl-2,3,3,3-tetrafluoropropionamide into 560g of sodium hydroxide solution, heat to 120°C for 5h, filter, heat the filtrate to 180°C for 5h, cool To room temperature, add HF to adjust the pH value to 4.8, distill under reduced pressure to remove water, add 260 g of ethanol for beating and filter, and distill the filtrate to remove ethanol under reduced pressure to obtain 72 g of 70% glycolic acid solution with a yield of 95.3%.

Embodiment 2

[0031] Put 140g of N,N-diethyl-2,3,3,3-tetrafluoropropionamide into 560g of potassium hydroxide solution, heat to 120°C for 5h, filter, heat the filtrate to 180°C for 5h, cool To room temperature, add HF to adjust the pH value to 5.5, distill under reduced pressure to remove water, add 260 g of ethanol for beating and filter, and distill the filtrate to remove ethanol under reduced pressure to obtain 73.4 g of 70% glycolic acid solution with a yield of 97.1%.

Embodiment 3

[0033] Put 140g of N,N-diethyl-2,3,3,3-tetrafluoropropionamide into 560g of sodium hydroxide solution, heat to 120°C for 5h, filter, heat the filtrate to 180°C for 5h, cool To room temperature, add HF to adjust the pH value to 6.0, remove water by distillation under reduced pressure, add 260 g of methanol for beating and filter, and distill the filtrate to remove methanol under reduced pressure to obtain 70 g of 70% glycolic acid solution with a yield of 92.6%.

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Abstract

The invention discloses a method for preparing glycollic acid. The method comprises the steps of hydrolyzing a byproduct, i.e., N,N-diethyl-2,3,3,3-tetrafluoropropionamide produced in a Florfenicol production process under alkaline conditions so as to obtain 2-hydroxylmalonate, carrying out heated decarboxylation so as to obtain 2-glycollate, and carrying out acidification, so as to obtain 2-glycolic acid, i.e., glycollic acid. According to the method, on one hand, the N,N-diethyl-2,3,3,3-tetrafluoropropionamide is treated and is changed into the valuable from the waste, so that environmental protection and resource-converting utilization are facilitated; and on the other hand, the used raw material is byproduct waste liquid, so that the production cost of the glycollic acid is low, the reaction conditions are mild, and the product quality is reliable.

Description

technical field [0001] The invention relates to the technical field of chemical production, in particular to a method for preparing glycolic acid. Background technique [0002] Glycolic acid is an important chemical raw material, mainly used in the manufacture of boiler descaling agents, cleaning agents, etc. It is also widely concerned as a raw material for polyglycolic acid, and polyglycolic acid is widely used in internal fixation of human or animal fractures, Repair of bone defects, repair of tendons, and suturing of human or animal blood vessels, muscles and other tissues. [0003] At present, the production process of glycolic acid in industry mainly adopts chloroacetic acid hydrolysis method and formaldehyde carbonylation method. [0004] (1) Chloroacetic acid hydrolysis method: Glycolic acid is prepared by catalytic hydrolysis of chloroacetic acid with sodium hydroxide, and the yield can reach more than 95%, and the product mass fraction can reach more than 98%. Th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C51/02C07C59/06
CPCC07C51/02C07C51/093C07C51/38C07C51/41C07C59/245C07C59/06
Inventor 乔建超李琦斌杨俊德王伟宏郭兴龙廖仕学
Owner SHANDONG GUOBANG PHARMA