Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Dihydrocodeine tartrate pharmaceutical composition and application thereof in biological medicine

A technology of dihydrocodeine and tartaric acid, which is applied in the field of biomedicine, can solve the problems that have not yet been reported on dihydrocodeine tartrate in acute gouty arthritis, and achieve the effect of improving the therapeutic effect

Pending Publication Date: 2016-11-09
周飞燕
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between dihydrocodeine tartrate and its pharmaceutical composition and acute gouty arthritis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dihydrocodeine tartrate pharmaceutical composition and application thereof in biological medicine
  • Dihydrocodeine tartrate pharmaceutical composition and application thereof in biological medicine
  • Dihydrocodeine tartrate pharmaceutical composition and application thereof in biological medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0019] Separation method: (a) Pulverize the kapok (3kg), extract with 75% ethanol under heat reflux (20L×3 times), combine the extracts, concentrate until no alcohol smell (4L), and then use petroleum ether (4L×3 times) ), ethyl acetate (4L × 3 times) and water-saturated n-butanol (4L × 3 times) extraction, respectively obtain petroleum ether extract, ethyl acetate extract and n-butanol extract; (b) step (a ) in n-butanol extract with AB-8 type macroporous resin for impurity removal, first elute 8 column volumes with 6% ethanol, then elute 8 column volumes with 70% ethanol, collect 70% eluate, decompress Concentrate to get 70% ethanol elution concentrate; (c) in step (b), 70% ethanol elution concentrate is separated with normal phase silica gel, and the volume ratio is 50:1 (8 column volumes), 25:1 ( 8 column volumes), 15:1 (8 column volumes) and 5:1 (10 column volumes) dichloromethane-methanol...

Embodiment 2

[0022] Embodiment 2: pharmacological action

[0023] In this example, sodium urate was used to prepare a rat model of acute gouty arthritis, and the test joint circumference and prostaglandin E in the joint cavity tissue were observed before and after drug treatment 2 (PGE), tumor necrosis factor-α (TNF-α) content and the number of white blood cells in the joint effusion.

[0024] 1. Materials and methods

[0025] 1.1 Animals

[0026] SD rats, male, clean grade, weighing 200-250 g, were provided by the Experimental Animal Center of Guangdong Medical College (. After 3 days of normal feeding in the laboratory, they were used for testing.

[0027] 1.2 Reagents and samples

[0028] Dihydrocodeine tartrate was purchased from China Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Sodium urate (supplied by Sigma), prostaglandin E 2 (PGE 2 ) radioimmunoassay kit (provided by Beijin...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a dihydrocodeine tartrate pharmaceutical composition and application thereof in biological medicine. The dihydrocodeine tartrate pharmaceutical composition contains dihydrocodeine tartrate and a natural product compound (I) with a novel structure, and when dihydrocodeine tartrate and the compound (I) act separately, the pharmaceutical composition has a therapeutic effect on acute gout arthritis; when dihydrocodeine tartrate and the compound (I) act in a combined mode, the therapeutic effect of the pharmaceutical composition on the acute gout arthritis is further improved; the dihydrocodeine tartrate pharmaceutical composition can be developed into drugs for treating the acute gout arthritis, and compared with the prior art, the dihydrocodeine tartrate pharmaceutical composition has prominent substantive features and significant progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of dihydrocodeine tartrate, in particular to a pharmaceutical composition of dihydrocodeine tartrate and its application in biomedicine. Background technique [0002] The pharmacological action of dihydrocodeine tartrate is the same as that of codeine, and its clinical application is similar to that of codeine. [0003] So far, there is no report on the correlation between dihydrocodeine tartrate and its pharmaceutical composition and acute gouty arthritis. Contents of the invention [0004] The object of the present invention is to provide a pharmaceutical composition of dihydrocodeine tartrate, which contains dihydrocodeine tartrate and a novel natural product, dihydrocodeine tartrate and the natural product Can synergistically treat acute gouty arthritis. [0005] Above-mentioned purpose of the present invention is achieved by following technical scheme: [0006]...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D311/76A61K31/485A61P29/00A61P19/02A61P19/06A61K31/352
CPCC07D311/76A61K31/352A61K31/485
Inventor 周飞燕
Owner 周飞燕
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com