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A kind of sulfonic acid modified capillary open-tubular column and preparation method thereof
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A capillary and open-column technology, used in the field of analytical chemistry, can solve problems affecting the properties of samples and buffer solutions, and achieve the effect of reducing adsorption and stable performance
Active Publication Date: 2019-06-25
HENAN UNIVERSITY
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Embodiment 1
[0025] Embodiment 1: The preparation method of the capillary open-tubular column modified by sulfonic acid comprises the following steps:
[0032] 6) Connect the capillary after the above treatment to the gas chromatograph, set the temperature of the column oven to 200°C, and pass high-purity N 2 Heat treatment under conditions for 1 hour for subsequent use;
[0033] The pretreatment step increases the number of exposed silanol groups on the quartz capillary wall, improving the reproducibility of the capillary coating.
[0034] (2) Carry out silanization reaction to the pretreated capillary
[0035] Mix 3-(methacryloyloxy)propyltrimethoxysilane with an equal vo...
Embodiment 2
[0038] Embodiment 2: the preparation method of the capillary open-tubular column modified by sulfonic acid, comprises the following steps:
[0045] 6) Connect the capillary after the above treatment to the gas chromatograph, set the temperature of the column oven to 200°C, and pass high-purity N 2 Heat treatment under conditions for 1 hour for subsequent use;
[0046] (2) Perform silanization reaction on the pretreated capillary. Mix 3-(methacryloyloxy)propyltrimethoxysilane with an equal volume of methanol evenly, then inject it into the pretreated capillary, and seal both ends. , react at 80°C for 12h, remove the seal, rinse the capillary with methanol to wash off th...
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Abstract
The present invention discloses a sulfuric acid-modified capillary open tubular column and a preparation method thereof and belongs to the technical field of analytical chemistry. The wall of the sulfuric acid-modified capillary open tubular column is keyed a matter that is 2-acrylamido-methyl-2--propanesulfonic acid. By modifying the inner wall of a quartz molten capillary with sulfuric groups to change its original physicochemical properties, compared with non-modified capillary, the column enables effectively reduced adsorption of some biological active matters to the wall of the quartz capillary so that the properties of the capillary are more stable.
Description
technical field [0001] The invention relates to a capillary column and a preparation method thereof, in particular to a preparation method of a sulfonic acid-modified capillary open-tubular column, which belongs to the field of analytical chemistry. Background technique [0002] Since its first report, capillary electrophoresis has developed into an important tool for the analysis of bioactive peptides and amino acids. Compared with some traditional analysis techniques (gas chromatography or high performance liquid chromatography), it has the advantages of high separation efficiency, short analysis time, and less sample demand. These advantages are very important for the analysis of biological samples. First, the matrix in which biological samples are located is very complex and the interference is relatively serious. An efficient separation technology is required for their separation. Second, it is very difficult to obtain biological samples, and the sample volume is very ...
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