Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pentoxifylline slow-release tablet and preparation method thereof

A technology of theobromine sustained-release tablets and pentoxifylline, which is applied in the direction of pharmaceutical formulas, medical preparations containing no active ingredients, and medical preparations containing active ingredients, etc. Sustained-release tablets have problems such as poor reproducibility of drug release, and achieve good sustained-release effects, good product quality uniformity, and good reproducibility.

Active Publication Date: 2016-11-23
CSPC OUYI PHARM CO LTD
View PDF5 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The inventor found through tests that the pentoxifylline sustained-release tablet prepared according to the method disclosed in this patent has poor drug release reproducibility, and the product is difficult to meet the preparation standard.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pentoxifylline slow-release tablet and preparation method thereof
  • Pentoxifylline slow-release tablet and preparation method thereof
  • Pentoxifylline slow-release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1 The preparation of pentoxifylline sustained-release tablets of the present invention

[0036]

[0037] Preparation Process:

[0038] 1) Add 90 g of pentoxifylline into molten glyceryl behenate, stir to disperse the drug evenly, cool in an ice bath for 6 hours, pulverize, and granulate with a 60-mesh sieve to obtain Granule 1;

[0039]2) Add the remaining pentoxifylline and polyoxyethylene into the granulator and stir at a speed of 100 rpm, and pre-mix for 5 minutes; then add 5% povidone K30 in 95% ethanol solution to make a soft material, and stir at 180 rpm, granulation for 10 minutes, granulation with a 20-mesh sieve, transfer the wet granules to a boiling dryer for drying, and the inlet air temperature is 60°C to obtain granules 2;

[0040] 3) Mix granule 1, granule 2, and magnesium stearate in a mixer for 10 minutes, the rotating speed is 12 rpm, and compressed into tablets (each tablet contains 0.4 g of pentoxifylline), and the tablet core hardness...

Embodiment 2

[0042] Embodiment 2 Preparation of Pentoxifylline Sustained-release Tablets of the Present Invention

[0043]

[0044] Preparation Process:

[0045] 1) Add 70 g of pentoxifylline into molten glyceryl behenate, stir to disperse the drug evenly, cool in an ice bath for 8 hours, pulverize, and sieve with a 60-mesh sieve to obtain Granule 1;

[0046] 2) Add the remaining pentoxifylline and polyoxyethylene into the granulator and stir at a speed of 105 rpm, pre-mix for 4 minutes; then add 5% povidone K30 in 95% ethanol solution to make a soft material, stir at a speed of 185 rpm, granulation for 12 minutes, granulation with a 20-mesh sieve, transfer the wet granules to a boiling dryer for drying, the inlet air temperature is 55°C, and granule 2 is obtained;

[0047] 3) Mix granule 1, granule 2, and magnesium stearate in a mixer for 11 minutes at a speed of 10 rpm, and press into tablets (each tablet contains 0.4 g of pentoxifylline), and the hardness of the tablet core is contr...

Embodiment 3

[0049] Embodiment 3 Preparation of Pentoxifylline Sustained-release Tablets of the Present Invention

[0050]

[0051] Preparation Process:

[0052] 1) Add 110 g of pentoxifylline into molten glyceryl behenate, stir to disperse the drug evenly, cool in an ice bath for 5 hours, pulverize, and granulate with a 60-mesh sieve to obtain Granule 1;

[0053] 2) Add the remaining pentoxifylline and polyoxyethylene into the granulator and stir at a speed of 95 rpm, and pre-mix for 3 minutes; then add 5% povidone K30 in 95% ethanol solution to make a soft material, and stir 190 rpm, granulation for 11 minutes, granulation with a 20-mesh sieve, transfer the wet granules to a boiling dryer for drying, and the inlet air temperature is 50°C to obtain granules 2;

[0054] 3) Mix granule 1, granule 2, and magnesium stearate in a mixer for 15 minutes at a speed of 11 rpm, and press into tablets (each tablet contains 0.4 g of pentoxifylline), and the hardness of the tablet core is controlle...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Hardnessaaaaaaaaaa
Login to View More

Abstract

The invention relates to a pentoxifylline slow-release tablet and a preparation method thereof, and belongs to the technical field of medicine preparations. The pentoxifylline slow-release tablet consists of a tablet core and a coating layer, wherein the tablet core is prepared from the following components of pentoxifylline, slow-release material and the like. The pentoxifylline slow-release tablet has the advantages that the type of auxiliary material is fewer, the formula technology is simple, the slow-release effect is good, the medicine-release reproducibility is good, the product stability is high, and the like.

Description

technical field [0001] The invention relates to a tablet and a preparation method thereof, more specifically to a pentoxifylline sustained-release tablet and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Pentoxifylline is a methylxanthine derivative. It is an alkaloid obtained from theobromine extracted from cocoa beans and then introduced into a pentanone group. It is a white powder or granule; it has a slight odor and a bitter taste; Soluble in chloroform, soluble in water or ethanol, slightly soluble in ether. Molecular formula is C 13 h 18 N 4 o 3 , the chemical name is 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione, and the structural formula is as follows: [0003] [0004] Pentoxifylline is a non-selective phosphodiesterase inhibitor. By inhibiting phosphodiesterase, it increases intracellular adenosine triphosphate, improves the deformability of red blood cells, reduce...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/36A61K31/522A61K47/14A61K47/34A61P9/10A61P9/14A61P13/12A61P3/10A61P25/02A61P29/00A61P25/00A61P1/16
CPCA61K9/0007A61K9/2013A61K9/2031A61K9/2866A61K31/522
Inventor 刘磊王唤雨郭倩甘丽倩韩丽霞
Owner CSPC OUYI PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com