Biomedical calcium sulfate/collagen composite particle and preparation method thereof

A biomedical, composite particle technology, applied in medical science, tissue regeneration, prosthesis, etc., can solve problems such as the impact of bone repair performance, and achieve the effect of promoting bone repair, easy industrialization, and simple operation

Active Publication Date: 2016-11-23
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the degradation rate of calcium sulfate dihydrate formed after calcium sulfate hemihydrate is still faster than the formation of new bone in the body, and its bone repair performance is affected to a certain extent.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Dissolve medical bovine Achilles tendon collagen in a hydrochloric acid solution with a pH value of 2 to form a collagen solution A with a concentration of 0.5 g / L; dissolve medical enzymatic collagen in a sodium hydroxide solution with a pH value of 10 to form a concentration of 0.5 Collagen solution B of g / L;

[0018] Mix α-calcium sulfate hemihydrate powder and collagen solution A at a weight ratio of 4:1, fill it into the mold, and let it stand until it solidifies into granules, demould, and then soak the demoulded granules at a volume ratio of 1:8 Put in collagen solution B for 12 hours; take out the particles and store them in an oven at 30° C. for 48 hours to obtain biomedical calcium sulfate / collagen composite particles. The weight percent of collagen in the composite particles is 0.01%.

Embodiment 2

[0020] Dissolve medical enzymatic collagen in acetic acid solution with a pH value of 4 to form a collagen solution A with a concentration of 10 g / L; dissolve medical bovine Achilles tendon collagen in a potassium hydroxide solution with a pH value of 12.5 to form a concentration of 2 g / L The collagen solution B;

[0021] Mix β-calcium sulfate hemihydrate powder and collagen solution A in a weight ratio of 3:1, fill it into the mold, and let it stand until solidified into granules, demould, and then soak the granules after demoulding at a volume ratio of 1:10 Put in collagen solution B for 18 hours; take out the particles and store them in an oven at 50° C. for 46 hours to obtain biomedical calcium sulfate / collagen composite particles. The weight percent of collagen in the composite particles is 0.5%.

Embodiment 3

[0023] The medical bovine Achilles tendon collagen is dissolved in a hydrochloric acid solution with a pH value of 2 to form a collagen solution A with a concentration of 20 g / L; the medical bovine Achilles tendon collagen is dissolved in a sodium hydroxide solution with a pH value of 12.4 to form a concentration of 20 g / L. Collagen solution B of L;

[0024] Mix α-calcium sulfate hemihydrate powder and collagen solution A in a weight ratio of 2:1, fill it into the mold, and let it stand until solidified into granules, demould, and then soak the granules after demoulding at a volume ratio of 1:12 Put in collagen solution B for 24 hours; take out the particles and store them in an oven at 60° C. for 40 hours to obtain the biomedical calcium sulfate / collagen composite particles. The weight percent of collagen in the composite particles is 2%.

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PUM

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Abstract

The biomedical calcium sulfate/collagen composite particle disclosed by the invention is composed of calcium sulfate and collagen. The particle contains 98-99.99% and 0.01-2% of collagen by weight. The preparation method includes the following steps: mixing calcium sulfate hemihydrate powder and medical collagen solution and casting to solidify into granules, wherein each granule is composed of calcium sulfate and collagen with controllable content. The ingredients in the calcium sulfate/collagen composite particle prepared by the method are controllable, and the calcium sulfate/collagen composite particle has good strength, biodegradable property and bone regeneration inducing ability and can be widely used in the field of biomedical materials such as bone filling materials.

Description

technical field [0001] The invention relates to biomedical calcium sulfate / collagen composite particles which can be used for repairing bone tissue defects and a preparation method thereof. Background technique [0002] Calcium sulfate has been used as an artificial bone repair material for hundreds of years. Calcium sulfate hemihydrate has become a research hotspot of inorganic bone repair materials and is widely used in bone repair because of its good biocompatibility, osteoconductivity, biodegradable absorbability and high compressive strength. However, the degradation rate of calcium sulfate dihydrate formed after calcium sulfate hemihydrate is still faster than the rate of new bone formation in vivo, and its bone repair performance is affected to a certain extent. [0003] There are many studies on the rapid degradation of calcium sulfate. Most of them are based on the different degradation rates of calcium sulfate and calcium phosphate, and the different ratios of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/12A61L27/50
CPCA61L27/12A61L27/24A61L27/50A61L2430/02A61L2430/12C08L89/00
Inventor 程逵何旭昭庄均珺翁文剑
Owner ZHEJIANG UNIV
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