Biomedical calcium sulfate/collagen composite particle and preparation method thereof
A biomedical, composite particle technology, applied in medical science, tissue regeneration, prosthesis, etc., can solve problems such as the impact of bone repair performance, and achieve the effect of promoting bone repair, easy industrialization, and simple operation
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Embodiment 1
[0017] Dissolve medical bovine Achilles tendon collagen in a hydrochloric acid solution with a pH value of 2 to form a collagen solution A with a concentration of 0.5 g / L; dissolve medical enzymatic collagen in a sodium hydroxide solution with a pH value of 10 to form a concentration of 0.5 Collagen solution B of g / L;
[0018] Mix α-calcium sulfate hemihydrate powder and collagen solution A at a weight ratio of 4:1, fill it into the mold, and let it stand until it solidifies into granules, demould, and then soak the demoulded granules at a volume ratio of 1:8 Put in collagen solution B for 12 hours; take out the particles and store them in an oven at 30° C. for 48 hours to obtain biomedical calcium sulfate / collagen composite particles. The weight percent of collagen in the composite particles is 0.01%.
Embodiment 2
[0020] Dissolve medical enzymatic collagen in acetic acid solution with a pH value of 4 to form a collagen solution A with a concentration of 10 g / L; dissolve medical bovine Achilles tendon collagen in a potassium hydroxide solution with a pH value of 12.5 to form a concentration of 2 g / L The collagen solution B;
[0021] Mix β-calcium sulfate hemihydrate powder and collagen solution A in a weight ratio of 3:1, fill it into the mold, and let it stand until solidified into granules, demould, and then soak the granules after demoulding at a volume ratio of 1:10 Put in collagen solution B for 18 hours; take out the particles and store them in an oven at 50° C. for 46 hours to obtain biomedical calcium sulfate / collagen composite particles. The weight percent of collagen in the composite particles is 0.5%.
Embodiment 3
[0023] The medical bovine Achilles tendon collagen is dissolved in a hydrochloric acid solution with a pH value of 2 to form a collagen solution A with a concentration of 20 g / L; the medical bovine Achilles tendon collagen is dissolved in a sodium hydroxide solution with a pH value of 12.4 to form a concentration of 20 g / L. Collagen solution B of L;
[0024] Mix α-calcium sulfate hemihydrate powder and collagen solution A in a weight ratio of 2:1, fill it into the mold, and let it stand until solidified into granules, demould, and then soak the granules after demoulding at a volume ratio of 1:12 Put in collagen solution B for 24 hours; take out the particles and store them in an oven at 60° C. for 40 hours to obtain the biomedical calcium sulfate / collagen composite particles. The weight percent of collagen in the composite particles is 2%.
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