a nerve electrode

An electrode and nerve technology, applied in the field of biomedical engineering, can solve the problems of difficult to achieve effective soft tissue fusion, poor biocompatibility, rigid electrode materials and soft tissue mechanical properties and other problems

Active Publication Date: 2018-09-25
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although traditional wire electrodes such as platinum, gold, titanium, etc. have made great progress, they still face the following problems: (1) The mechanical properties of rigid electrode materials and soft tissues are very different, making it difficult to achieve effective fusion with soft tissues ; (2) Poor charge injection efficiency; (3) Poor biocompatibility

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: Preparation of neural electrodes

[0038] Include the following steps:

[0039] (1) bonding the three-dimensional porous graphene electrode 4 to the silver wire through silver glue, and heating to 70° C. to completely cure the silver glue, and the thickness of the three-dimensional porous graphene electrode 4 is 0.5 mm;

[0040] (2) Soak the connecting part of the silver wire and the three-dimensional porous graphene electrode 4 in the PDMS solution, vacuumize to remove the air bubbles in the mixed solution, and heat the PDMS at 70° C. for 6 hours to solidify the PDMS to obtain a protective substrate 6 with a thickness of 2 mm;

[0041] (3) The three-dimensional porous graphene electrode 4 with the protective substrate 6 and the metal titanium electrode are respectively connected to the current generating device 1 through silver wires to prepare a nerve electrode.

Embodiment 2

[0042] Example 2: Preparation of neural electrodes

[0043] Include the following steps:

[0044] (1) bonding the three-dimensional porous graphene electrode 4 and the copper wire through silver glue, and heating to 50° C. to completely solidify the silver glue, and the thickness of the three-dimensional porous graphene electrode 4 is 2 mm;

[0045] (2) Soak the connecting part of the copper wire and the three-dimensional porous graphene electrode 4 in the PDMS solution, vacuumize to remove the air bubbles in the mixed solution, and keep the PDMS at 100° C. for 1 hour to solidify the PDMS to obtain a protective substrate 6 with a thickness of 0.5 mm. ;Before the PDMS is cured, a heart-shaped mold can be gently pressed on the graphene surface to cause a heart-shaped deformation. After the PDMS is completely cured, a recessed electrode can be obtained to better fit the heart area;

[0046] (3) The three-dimensional porous graphene electrode 4 with the protective substrate 6 and...

Embodiment 3

[0047] Example 3: Preparation of neural electrodes

[0048] Include the following steps:

[0049] (1) bonding the three-dimensional porous graphene electrode and the silver wire through silver glue, and heating to 60° C. to completely solidify the silver glue, and the thickness of the three-dimensional porous graphene electrode 4 is 1 mm;

[0050] (2) Quickly soak the connecting part of the silver wire and the three-dimensional porous graphene electrode 4 in the polyurethane solution, vacuumize to remove the air bubbles in the mixed solution, and place it at room temperature for 24 hours to solidify the polyurethane, and the obtained protective substrate 6 is about 1mm thick.

[0051] (3) The three-dimensional porous graphene electrode 4 with the protective substrate 6 and the metal gold electrode are respectively connected to the current generator 1 through silver wires to prepare a nerve electrode.

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Abstract

The invention provides a neural electrode with high charge injection efficiency and good biocompatibility. The neural electrode comprises a current generating device, a first electrode and a second electrode, wherein the current generating device is connected with the first electrode and the second electrode through conductive metal wires; at least one of the first electrode and the second electrode is a graphene electrode; the graphene electrode is a three-dimensional porous graphene electrode, is soft in texture and good in stability, and can bear repeated pressing and folding; the neural electrode has extremely high charge injection efficiency, is used for electrically stimulating tissues and organs such as a heart and nerve, and can be used for promoting electrical stimulation recovery of nerve cells and further promoting recovery of neural function; the neural electrode is good in biocompatibility and good in stability in vivo; the nerve cells can be cultured on the surface of the neural electrode and are high in survival rate.

Description

technical field [0001] The invention belongs to the field of biomedical engineering, in particular to a three-dimensional porous graphene flexible nerve electrode and a preparation method thereof. Background technique [0002] Neuron, the basic functional unit of neural activity, has the function of receiving stimulation and conducting impulse excitation. Electrical stimulation therapy stimulates the nerve tissue in direct contact by applying an electrical signal of appropriate waveform and frequency on the nerve electrode, activating neuron activity, thereby improving the nervous system. dysfunction. Cardiac pacemaker is an electronic therapy device implanted in the body. It outputs electric pulses powered by batteries through the pulse generator, and stimulates the myocardium in contact with the electrodes through the conduction of the wire electrodes, so as to excite and contract the heart, so as to achieve a certain therapeutic effect. Cardiac dysfunction caused by arrh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61N1/05
CPCA61N1/0529A61N1/0551A61N1/056A61N1/0587
Inventor 罗居东张琦张舒羽宋琴周希法曹建平
Owner SUZHOU UNIV
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