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Preparation method of calcium glycinate chelate

A technology of calcium glycinate and chelate compound, applied in the field of preparation of calcium glycinate chelate compound, can solve the problems of easily causing stones in the body and gastrointestinal irritation symptoms, restricting the development of industrialization, difficult crystallization of products, etc. The effect of not easy to agglomerate and low production cost

Active Publication Date: 2016-11-23
HEBEI DONGHUA JIHENG CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first generation of inorganic calcium salts requires a large amount of gastric acid to be dissociated into Ca in the body 2+ It can be absorbed and utilized, has poor biological activity, and has certain side effects, which are more likely to cause stones in the body and gastrointestinal irritation symptoms
Compared with inorganic calcium, the second generation of traditional organic salt calcium has better solubility and less irritation to the gastrointestinal tract. The disadvantage is that the calcium content is relatively low and the absorption is poor.
However, there are many problems in the current production of calcium glycinate, such as complex process, energy consumption, difficult crystallization of the product, low yield, and high cost, which limit its industrialization development.

Method used

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  • Preparation method of calcium glycinate chelate
  • Preparation method of calcium glycinate chelate
  • Preparation method of calcium glycinate chelate

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Present embodiment is to prepare calcium glycinate chelate, concrete steps are as follows:

[0035] 1) Synthetic reaction: take raw materials glycine 75Kg (about 1 kilomole), calcium oxide 30.8Kg (about 0.55 kilomole), calcium acetate 3.95Kg (about 0.025 kilomole) and water 120 liters, put the raw materials into the reaction kettle, Stir and mix, heat to 75°C, and react for 4 hours to obtain a reaction solution;

[0036] 2) Product purification: filter the reaction solution while it is hot (at a temperature of 75° C.) to obtain a primary filtrate and a primary filter residue, then add 300 liters of ethanol to the primary filtrate for alcohol analysis. Separation, alcohol separation and precipitate were obtained, and the precipitate was dried at 50° C. for 4 hours to obtain 93.7 kg of calcium glycinate chelate product with a yield of 91%. After testing, the product purity was 99.82%.

[0037] 3) Post-treatment: The alcohol separation liquid was rectified at 80°C for 2 h...

Embodiment 2

[0042] Present embodiment is to prepare calcium glycinate chelate, concrete steps are as follows:

[0043] 1) Synthetic reaction: Take 150Kg (about 2 kilomoles) of raw material glycine, 61.6Kg (about 1.1 kilomoles) of calcium oxide, 7.9Kg (about 0.05 kilomoles) of calcium acetate and 240 liters of water, put the raw materials into the reaction kettle, Stir and mix, heat to 70°C, and react for 4 hours to obtain a reaction solution;

[0044] 2) Product purification: filter the reaction solution while it is hot (at a temperature of 70° C.) to obtain a primary filtrate and a primary filter residue, and then add 600 liters of ethanol to the primary filtrate for alcohol analysis. Separation, alcohol separation and precipitate were obtained, and the precipitate was dried at 50° C. for 4 hours to obtain 185.4 kg of calcium glycinate chelate product with a yield of 92%. After testing, the product purity was 100.50%.

[0045] 3) Post-processing: the alcohol separation liquid was rectif...

Embodiment 3

[0047]1) Synthetic reaction: take 75Kg (about 1 kilomol) of raw material glycine, 30.8Kg (about 0.55 kilomol) of calcium oxide, 3.16Kg (about 0.02 kilomol) of calcium acetate and 120 liters of water, and put the raw materials into the reaction kettle. Stir and mix, heat to 90°C, and react for 4 hours to obtain a reaction solution;

[0048] 2) Product purification: filter the reaction solution while it is hot (at a temperature of 80° C.) to obtain a primary filtrate and a primary filter residue, then add 400 liters of ethanol to the primary filtrate for alcohol analysis, and leave it to stand for 3 hours. Separation, alcohol separation liquid and precipitates were obtained, and the precipitates were dried at 40° C. for 6 hours to obtain 92.7 kg of calcium glycinate chelate product with a yield of 90%. After testing, the product purity was 99.95%.

[0049] 3) Post-processing: the alcohol separation liquid was rectified at 80°C for 2.5 hours to obtain 392 liters of ethanol, the r...

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Abstract

The invention relates to a preparation method of a calcium glycinate chelate. The method comprises the following three steps: 1) synthesis reaction: adding glycine, calcium oxide, calcium acetate and water into a reaction kettle according to certain proportion, stirring and mixing, and heating to the reaction temperature, wherein reaction liquid is obtained after some time of reaction; 2) product purification: filtering while the reaction liquid is hot to obtain primary filtrate and primary filter residue; performing alcohol precipitation of the primary filtrate; standing for a period of time, and performing centrifugal separation to obtain alcohol precipitation liquid and precipitate; and drying the precipitate to obtain a product of calcium glycinate chelate; and 3) aftertreatment: rectifying the alcohol precipitation liquid and recycling the alcohol for alcohol precipitation again; and returning the rectifying still liquid and the primary filter residue into the reaction kettle for recycling. The method provided by the invention has the advantages of simple production technical process, high production efficiency, low production cost, no generation of three wastes and the like, and facilitates industrial production; and the product of calcium glycinate chelate has good dispersity and does not cake easily.

Description

technical field [0001] The invention relates to the technical field of calcium supplement preparations, in particular to a preparation method of a calcium glycinate chelate. Background technique [0002] Calcium is one of the most abundant elements in the body, and it is also one of the most easily deficient elements. It is the main component of human bones and teeth, and plays an important regulatory role in maintaining the normal physiological functions of human circulation, breathing, nerves, endocrine, digestion, blood, muscle, bone, urinary, immune and other systems. According to statistics, among China's 1.3 billion population, 37% of children and 59% of middle-aged and elderly people are calcium deficient. Residents' daily intake of dietary calcium is generally low, and at the same time the absorption rate of calcium is also very low. Therefore, calcium supplementation has become one of the major problems we need to solve. [0003] The development of calcium supple...

Claims

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Application Information

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IPC IPC(8): C07C227/18C07C227/40C07C229/76
CPCC07C227/18C07C227/40C07C229/76
Inventor 冯辉王秀茹徐志伟王娜宋铁犇赵红梅马宁宁刘瑞英宋秋月
Owner HEBEI DONGHUA JIHENG CHEM
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