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Medical polymer and preparation method thereof

A polymer and composition technology, applied in the field of preparing polylactic acid with high biological safety, can solve the problems of stannous chloride catalyst removal, medical devices with potential safety hazards, etc.

Inactive Publication Date: 2016-11-23
张锐 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, none of the above-mentioned methods can solve the problem that the stannous chloride catalyst used in the synthesis of polylactic acid by the existing polycondensation method cannot be completely removed from the polymer, which has potential safety hazards and cannot be applied to the field of medical devices.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] 100 g of 90 wt % L-lactic acid aqueous solution was added to the four-necked flask, and the flask was placed in an oil bath. Install a stirrer on the four-neck flask, insert a thermocouple thermometer, connect the vacuum pipeline and the nitrogen pipeline and replace with nitrogen for 3 times, then add 39.13 μl of sulfuric acid under the protection of nitrogen. Then the temperature of the system is raised to 120°C and the pressure of the system is gradually reduced from normal pressure to 5KPa within 1 hour; after being kept at 5KPa for 1.5 hours, the temperature of the oil bath is raised to 160°C, and the pressure is gradually reduced to 0.3KPa within 2 hours And keep the pressure at 0.3KPa under the condition of melt polymerization for 12 hours, pour it out, and cool to obtain a polylactic acid prepolymer.

[0053] Inject 100 g of 90 wt % glycolic acid aqueous solution into the four-necked flask, and put the flask into an oil bath. Install a stirrer on the four-neck ...

Embodiment 2

[0060] 100 g of 90 wt % L-lactic acid aqueous solution was added to the four-necked flask, and the flask was placed in an oil bath. Install a stirrer on the four-neck flask, insert a thermocouple thermometer, connect the vacuum pipeline and the nitrogen pipeline and replace it with nitrogen for 3 times, then add 83.15 μl of sulfuric acid under the protection of nitrogen. Then the temperature of the system is raised to 120°C and the pressure of the system is gradually reduced from normal pressure to 5KPa within 1 hour; after being kept at 5KPa for 1.5 hours, the temperature of the oil bath is raised to 160°C, and the pressure is gradually reduced to 0.3KPa within 2 hours Keep the pressure at 0.3KPa and pour it out after melt polymerization for 8 hours, and cool to obtain a polylactic acid prepolymer.

[0061] Inject 100 g of 90 wt % glycolic acid aqueous solution into the four-necked flask, and put the flask into an oil bath. Install a stirrer on the four-neck flask, insert a ...

Embodiment 3

[0069] 100 g of 90 wt % L-lactic acid aqueous solution was added to the four-necked flask, and the flask was placed in an oil bath. Install a stirrer on the four-neck flask, insert a thermocouple thermometer, connect the vacuum pipeline and the nitrogen pipeline and replace it with nitrogen for 3 times, then add 83.15 μl of sulfuric acid under the protection of nitrogen. Then the temperature of the system is raised to 120°C and the pressure of the system is gradually reduced from normal pressure to 5KPa within 1 hour; after being kept at 5KPa for 1.5 hours, the temperature of the oil bath is raised to 160°C, and the pressure is gradually reduced to 0.3KPa within 2 hours Keep the pressure at 0.3KPa and pour it out after melt polymerization for 6 hours, and cool to obtain a polylactic acid prepolymer.

[0070]Inject 100 g of 90 wt % glycolic acid aqueous solution into the four-necked flask, and put the flask into an oil bath. Install a stirrer on the four-neck flask, insert a t...

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Abstract

The invention discloses a medical polymer containing sulfuric acid compound and a preparation method thereof, and the medical polymer comprises a lactic acid / glycolic acid copolymer with a weight average molecular weight of 50,000-300,000 and 100 to 10000ppm sulfuric acid compound. According to the method, lactic acid and glycolic acid are used as raw materials, sulfuric acid single catalyst is added for melt polycondensation to obtain polylactic acid and polyglycolic acid prepolymers respectively; and high molecular weight polylactic acid can be obtained by further melt mixing of the obtained melt polycondensation products of the polylactic acid prepolymer, the polyglycolic acid prepolymer and lactic acid / glycolic acid copolymer and further solid phase polymerization. The thermal stability of the medical polymer obtained by the method is fundamentally improved. In addition, the medical polymer obtained by the method has high molecular weight, and the hydrolysis resistance of the product is fundamentally improved, so that the medical polymer is safe for using in food packaging and medical materials.

Description

technical field [0001] The invention belongs to the field of medical polymer materials, and in particular relates to a lactic acid / glycolic acid copolymer composition containing a sulfuric acid compound and a method for preparing polylactic acid with high biological safety by using sulfuric acid as a catalyst. Background technique [0002] In the 21st century, with the rapid development of medicine and biomedical science, the demand for medical biodegradable materials with excellent biocompatibility and biosafety is increasing rapidly. Polylactic acid (PLA) is a degradable material derived from renewable resources that is currently researched and applied relatively more. It is a non-toxic and non-irritating material prepared from lactic acid obtained from starch fermentation (or chemical synthesis) Environmentally friendly material, it not only has good physical properties, but also has good biocompatibility and degradation performance. Biodegradable polylactic acid has ach...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/06C08G63/87C08G63/80C08G63/78
Inventor 不公告发明人
Owner 张锐