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Biomimetic layered stent for periodontal tissue defect repair and preparation method thereof

A periodontal tissue and bionic layer technology, applied in the field of bionics, can solve the problems of chronic tissue inflammation, inability to fully produce the three-layer structure of periodontal tissue, etc., to ensure the effect of periodontal repair

Active Publication Date: 2016-12-21
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Recently, Bottino et al. designed a layered PLGA / collagen / nano-hydroxyapatite biofilm material with a gradient structure for the repair of periodontal tissue defects, and confirmed that there are more fibroblasts and osteoblasts attached to the scaffold. , the compatibility and degradation performance of the scaffold have been improved, but the degradation products of PLGA are acidic, which will cause local chronic inflammation in the tissue for a long time. In addition, the membrane material cannot completely produce the three-layer structure of the periodontal tissue

Method used

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  • Biomimetic layered stent for periodontal tissue defect repair and preparation method thereof
  • Biomimetic layered stent for periodontal tissue defect repair and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0044] 1. Synthesis of CH-PCL copolymer: 6g of chitosan with a degree of deacetylation of 100% and 18g of phthalic anhydride were heated to 130°C in dry dimethylformamide, and reacted for 5 -7 hours, the mixture turned into a clear yellow liquid; this moment to obtain the intermediate product A (phthalylated chitosan), then the above-mentioned mixture containing A and 21g of caprolactone in N 2 Protection, stirring constantly under the condition of 100 ℃, reacting for 20 hours, at this time, the intermediate product B (phthalylated chitosan-g-polycaprolactone) is obtained, and then the reactant is placed in a Soxhlet extractor Extract with acetone for 24 hours to remove the homopolymer in the reaction; finally take 30g of the extracted B product and dissolve it in 600ml of dimethylformamide, 100°C, N 2 Incubate for 2 hours under protective conditions, cool to room temperature and allow it to precipitate naturally, collect the precipitate, rinse with double distilled water and ...

Embodiment 2

[0073] 1. Synthesis of CH-PCL copolymer: 20g of chitosan with 100% degree of deacetylation and 60g of phthalic anhydride were heated to 130°C in dry dimethylformamide, and reacted for 5 -7 hours, the mixture turned into a clear yellow liquid; at this moment, the intermediate product A (phthalylated chitosan) was obtained, and then the above-mentioned mixture containing A and the caprolactone of 72g were protected in N , at 100C Stir constantly under condition, react 20 hours, obtain intermediate product B (phthalylated chitosan-g-polycaprolactone) this moment, then reactant is placed in Soxhlet extractor with acetone extraction 24 hours to remove homopolymers in the reaction; finally take 42g of the extracted B product and dissolve it in 840ml of dimethylformamide, incubate at 100°C for 2 hours under N2 protection conditions, cool to room temperature and allow it to precipitate naturally, and collect the precipitate The substance was rinsed with double distilled water and etha...

Embodiment 3

[0102]1. Synthesis of CH-PCL copolymer: 14g of chitosan with a degree of deacetylation of 100% and 42g of phthalic anhydride were heated to 130°C in dry dimethylformamide, and reacted under conventional experimental conditions for 5 -7 hours, the mixture turned into a clear yellow liquid; at this time, the intermediate product A (phthalylated chitosan) was obtained, and then the above-mentioned mixture containing A and 21g of caprolactone were protected under N2 at 100°C Stir constantly under the condition, react 20 hours, obtain intermediate product B (phthalylated chitosan-g-polycaprolactone) at this moment, then reactant is placed in Soxhlet extractor and extracted with acetone 24 hours to remove the homopolymer in the reaction; finally take 36g of the extracted B product and dissolve it in 720ml of dimethylformamide, incubate at 100°C for 2 hours under N2 protection conditions, cool to room temperature and allow it to precipitate naturally, collect The precipitate was rins...

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Abstract

The invention provides a biomimetic layered stent for periodontal tissue defect repair and a preparation method thereof. The stent comprises a cementum layer, an alveolar bone layer and a parodontium layer located between the cementum layer and alveolar bone layer. During preparation, a chitosan-polycaprolactone copolymer is firstly synthesized, wherein the side chain substitution degree and chain length of the polycaprolactone are adjustable. The mechanics, expansion, degradation and hydrophobicity and hydrophilicity of the copolymer are controlled by changing the PCL side chain length and the PCL content in CH-PCL, the optimized CH-PCL treated by using an available water-based solvent serves as a main material for preparation of the biomimetic layered stent.

Description

technical field [0001] The invention belongs to the field of bionics, in particular to a bionic layered support for periodontal tissue defect repair and a preparation method thereof. Background technique [0002] The loss of periodontal attachment and alveolar bone defect caused by periodontitis may lead to the final loss of teeth. This disease has a high incidence in my country and has become one of the oral diseases that seriously affect the quality of life of patients. [0003] At present, the clinical treatment principle of periodontal disease is mainly to eliminate periodontal pathogenic factors and control inflammation by controlling oral plaque and microorganisms, removing calculus, and improving oral microenvironment. Specific methods include basic periodontal treatment with mechanical scaling and root planing as the core, combined with drug treatment, and the application of new technologies and materials. These treatment methods can control the development of perio...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/54A61L27/38A61L27/20A61L27/18A61L27/12A61L27/22
CPCA61L27/12A61L27/18A61L27/20A61L27/225A61L27/3804A61L27/3865A61L27/54A61L2300/414C08L5/08C08L67/04
Inventor 朱有家万影王九龙
Owner WUHAN UNIV
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