Gold/quaternary carbon dot core-shell nanocomposite and preparation method thereof

A nano-composite material and composite material technology, which are applied in the field of gold/quaternary carbon point core-shell nano-composite materials and preparation, can solve the problems of implanted heat source, low heating efficiency, uneven thermal field distribution, etc. Good, low toxicity, good effect

Active Publication Date: 2017-01-04
TANGSHAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these heating methods have disadvantages such as uneven thermal field distribution a

Method used

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  • Gold/quaternary carbon dot core-shell nanocomposite and preparation method thereof
  • Gold/quaternary carbon dot core-shell nanocomposite and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Preparation of quaternary carbon dots:

[0022] Weigh 1 g of betaine hydrochloride and dissolve it in 20 mL of deionized water, then add tris in a molar ratio of 1:1, and after it is completely dissolved, add excess isopropanol, and the obtained slurry is at 70 o Dry under vacuum at C for 36h. Muffle furnace 250 for dried sticky white matter o After heating at C for 2 hours, 0.8 g of brown solid was obtained, which was added to 50 mL of deionized water. The amount of deionized water used here was 50-100 times the weight of the brown solid, and the formed brown dispersion was precipitated with 65 mL of acetone. , the dosage ratio of acetone and deionized water in the brown dispersion liquid is 1:1-2:1, and the dark brown powder can be obtained by drying at room temperature, that is, the quaternary carbon dots.

[0023] (2) Preparation of gold nanoparticles:

[0024] Weigh 2g of sapphire gum into 20mL of deionized water, centrifuge at 11000rpm for 6 minutes with a ...

Embodiment 2

[0028] (1) Preparation of quaternary carbon dots:

[0029] Weigh 1.5g of betaine hydrochloride and dissolve it in 30mL of deionized water, then add tris(hydroxymethylaminomethane) with a molar ratio of 1:1, and after it is completely dissolved, add excess isopropanol to obtain a slurry at 65 o Dry under vacuum for 48h. Muffle furnace 250 for dried sticky white matter o After heating at C for 2 hours, 1.2 g of brown solid was obtained, which was added to 100 mL of deionized water. The amount of deionized water used here was 50-100 times the weight of the brown solid, and the formed brown dispersion was precipitated with 150 mL of acetone. , the dosage ratio of acetone and the deionized water in the brown dispersion liquid is 1:1-2:1, and the dark brown powder can be obtained by drying at room temperature, that is, the quaternary carbon dots.

[0030] (2) Preparation of gold nanoparticles:

[0031] Weigh 2.5g of sapphire gum into 30mL of deionized water, centrifuge at 12000rp...

Embodiment 3

[0035] (1) Preparation of quaternary carbon dots:

[0036] Weigh 2g of betaine hydrochloride and dissolve it in 40mL of deionized water, then add tris(hydroxymethylaminomethane) with a molar ratio of 1:1, after it is completely dissolved, add excess isopropanol, and the obtained slurry is at 70 o Dry under vacuum at C for 48h. Muffle furnace 250 for dried sticky white matter o After heating at C for 2 hours, 1.4 g of brown solid was obtained, which was added to 90 mL of deionized water. The amount of deionized water used here was 50-100 times the weight of the brown solid, and the formed brown dispersion was precipitated with 120 mL of acetone, The dosage ratio of acetone and deionized water in the brown dispersion liquid is 1:1-2:1, and the dark brown powder can be obtained by drying at room temperature, that is, the quaternary carbon dots.

[0037] (2) Preparation of gold nanoparticles:

[0038] Weigh 2.2g of sapphire gum into 35mL of deionized water, centrifuge at 10,000...

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Abstract

The invention discloses a gold/quaternary carbon dot core-shell nanocomposite and a preparation method. Gold nanoparticles serve as the core of the composite, and quaternary carbon dots serve as the shell of the composite. The method includes the steps that betaine hydrochloride is dissolved in deionized water, tris(hydroxymethyl)methyl aminomethane is added, isopropanol is added after dissolution, and obtained paste is subjected to vacuum drying; the paste is heated with a muffle furnace after being dried, a brown solid is obtained and added into deionized water, formed brown dispersion liquid is precipitated with acetone, indoor-temperature drying is carried out, and quaternary carbon dots are obtained; sesbania gum is added into deionized water, centrifugal separation is carried out, the supernatant liquor part is taken, a chloroauric acid solution is added, magnetic stirring is carried out, and gold nanosol is obtained; quaternary carbon dots are dissolved in deionized water, gold nanosol is added, ultrasonic dispersion is carried out in a probe ultrasonic crusher, and the composite is obtained. The composite has the infrared absorption function, stable fluorescence, particle-size monodispersity, hypotoxicity and good biocompatibility, achieves treatment and real-time form monitoring of cancer cells in the organism and has application prospects in the tumor treatment field.

Description

technical field [0001] The invention belongs to the field of nanocomposite materials, and relates to a core-shell type nanocomposite material, in particular to a gold / quaternary carbon point core-shell nanocomposite material and a preparation method. Background technique [0002] Malignant tumor (cancer) is one of the major diseases that seriously threaten human life in today's society. Due to the low sensitivity and low specificity of conventional diagnostic methods for cancer, it is difficult to detect cancer cells in the early stage. Therefore, once many patients are found to be infected by cancer cells, most of them are in the middle and late stages, and they have missed the best period of cure. In addition, chemotherapy is one of the main methods of treating tumor diseases at present, but it is a systemic treatment method. While killing tumor cells, it also kills normal cells and immune cells together. " treatment method. In recent years, hyperthermia is a method of c...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K49/00A61P35/00
CPCA61K41/0052A61K49/0065A61K49/0093
Inventor 张青
Owner TANGSHAN NORMAL UNIV
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