Cefalexin oil suspension and preparation method thereof

A technology of cephalexin oil and cephalexin, which is applied in the field of medicine, can solve the problems of inability to disperse agglomeration, prone to flocculation, waste of medicines, etc., and achieves the advantages of good needle penetration and dispersibility, high sample qualification rate and good application prospect. Effect

Inactive Publication Date: 2017-01-11
CHENGDU QIANKUN VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of oil suspensions, especially oil suspensions for injection, is relatively difficult. To obtain products with better physical stability, needle penetration and redispersibility, it is very critical to determine the type and amount of suitable excipients. Moreover, oil Suspensions have high requirements on the storage environment, and improving their storage stability is also a factor that needs to be considered during the preparation process
[0004] The cephalexin oil suspension is included in the

Method used

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  • Cefalexin oil suspension and preparation method thereof
  • Cefalexin oil suspension and preparation method thereof
  • Cefalexin oil suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0022] Example 1 Preparation of cephalexin oil suspension of the present invention

[0023] Take 30ml of soybean oil, add 30ml of benzyl benzoate, heat (60℃-70℃) and mix well, add 1.0g of colloidal protective agent, aluminum magnesium silicate and magnesium stearate (1:1) mixture, dissolve it, and add auxiliary The suspending agent (Poloxamer 188 5.0g, polyethylene glycol 6000 2.5g) is melted and stirred evenly, and the surfactant soy phospholipid 0.3g, Tween-80 0.3g and Span-800.3g are added, and the auxiliary agent is added after cooling. Suspension (1.0 g of sodium carboxymethyl cellulose), stir evenly, add 10 g of cephalexin, stir evenly, dilute the volume to 100 ml with soybean oil, and homogenize to obtain a 10% cephalexin oil suspension.

Example Embodiment

[0024] Example 2 Preparation of cephalexin oil suspension of the present invention

[0025] Take 30ml of soybean oil, add 30ml of isopropyl myristate, heat (60℃-70℃) and mix well, add 1.0g of colloidal protective agent, magnesium aluminum silicate and magnesium stearate (1:1) mixture, dissolve, and then Add suspending agent (Poloxamer 188 1.0g, polyethylene glycol 6000 2.5g) to melt and stir evenly, add surfactant soy phospholipid 0.3g, Tween-80 0.3g and Span-80 0.3g, cool Then add a suspending agent (5.0 g of sodium carboxymethyl cellulose), stir evenly, add 10 g of cephalexin, stir evenly, dilute to 100 ml with soybean oil, and homogenize to obtain a 10% cephalexin oil suspension.

Example Embodiment

[0026] Example 3 Preparation of cephalexin oil suspension of the present invention

[0027] Take 30ml of soybean oil, add 30ml of isopropyl myristate, heat (60℃-70℃) and mix well, add 1.0g of colloidal protective agent, magnesium aluminum silicate and magnesium stearate (1:1) mixture, dissolve, and then Add suspending agent (Poloxamer 188 2.5g, polyethylene glycol 6000 5.0g) to melt and stir well, add surfactant soy phospholipid 0.3g, Tween-80 0.3g and Span-80 0.3g, cool Then add a suspending agent (5.0 g of sodium carboxymethyl cellulose), stir evenly, add 10 g of cephalexin, stir evenly, dilute the volume to 100 ml with soybean oil, and homogenize to obtain a 10% cephalexin oil suspension.

[0028] The following uses experimental examples to illustrate the beneficial effects of the present invention:

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Abstract

The invention discloses a cefalexin oil suspension. Every 100mL of the suspension contains the following raw and auxiliary materials: 2-30g of cefalexin, 0.9-1.0g of surfactant, 1.0-5.0g of colloid protective agent, 7.5-12.5g of suspending agent, 0-0.1% of antioxidant and the balance of oil phase. Under the condition of adopting specific auxiliary material varieties and proportions, the prepared suspension has the advantages of favorable physical stability, favorable needle penetrability and favorable redispersibility, and does not have the condition of quality reduction after being stored in a 4-60-DEG C environment for 3 months, which indicates stable quality.

Description

technical field [0001] The invention relates to a cephalexin oil suspension and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Cephalexin, a β-lactam antibiotic, is a white or milky yellow crystalline powder; slightly odorous, it can inhibit the synthesis of cell walls, make the contents of cells swell to rupture and dissolve, and kill bacteria. Cephalexin is a first-generation cephalosporin, which has antibacterial effects on both Gram-positive and Gram-negative bacteria, and is a commonly used veterinary drug. [0003] Oil suspension is a heterogeneous liquid preparation formed by dispersing insoluble drugs in the oil phase. Its biggest feature is to prolong the drug's action time, reduce the frequency of medication, reduce labor intensity and reduce stress on the body. However, the preparation of oil suspensions, especially oil suspensions for injection, is relatively difficult. To obtain products with better physical stab...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K47/44A61K47/14A61K47/26A61K47/24A61K47/12A61K47/02A61K47/10A61K47/38A61K47/22A61K31/545A61P31/04
CPCA61K9/10A61K31/545A61K47/02A61K47/10A61K47/12A61K47/14A61K47/22A61K47/24A61K47/26A61K47/38A61K47/44
Inventor 杨海涵黄兴欧红萍刘海燕房春林
Owner CHENGDU QIANKUN VETERINARY PHARMA
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