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Starch/poloxamer composite styptic powder and preparation method thereof

A technology of poloxamer and hemostatic powder, which is applied in the field of medicine, can solve the problems of animal-derived raw materials, high price, and slow degradation, and achieve good market prospects, simple production, and good cohesive effects

Active Publication Date: 2017-01-11
山东奥能医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these products have more or less problems: animal-derived raw materials, slow degradation, susceptible to infection, expensive, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Weigh 64g of potato starch and 0.5g of sodium trimetaphosphate, add them into 100ml of sodium hydroxide solution with a pH of 10, and react at 45°C for 5h. After the reaction, wash with water until neutral, dehydrate with 95% ethanol, centrifuge, and dry in an oven.

[0024] (2) Weigh 20g of the product obtained in step (1), 2.8g of sodium hydroxide, add 28ml of water to dissolve, add 168ml of ethanol, mix well, and react at 30°C for 2h. Add 44 ml of sodium chloroacetate ethanol water (sodium chloroacetate: ethanol: water = 1 g: 10 ml: 10 ml) solution. The temperature was raised to 50°C for 3h. After the reaction, adjust to neutral with dilute hydrochloric acid, wash twice with ethanol-water (volume ratio 6:4), centrifuge, and dry in an oven.

[0025] (3) Weigh 9.7g of the product obtained in step (2) and 0.3g of poloxamer, add it to the ethanol-water (volume ratio 6:1) solution, stir at 40°C for 1h, spray dry, and sterilize to obtain starch / Poloxamer complex he...

Embodiment 2

[0027] (1) Weigh 64g of potato starch and 0.5g of sodium trimetaphosphate, add them into 100ml of sodium hydroxide solution with a pH of 14, and react at 35°C for 6h. After the reaction, wash with water until neutral, dehydrate with 95% ethanol, centrifuge, and dry in an oven.

[0028] (2) Weigh 20g of the product obtained in step (1), 4.0g of sodium hydroxide, add 40ml of water to dissolve, add 240ml of ethanol, mix well, and react at 25°C for 5h. Then add sodium chloroacetate ethanol water (sodium chloroacetate: ethanol: water = 1 g: 10 ml: 10 ml) solution 50 ml. The temperature was raised to 60° C. for 1 h. After the reaction, adjust to neutral with dilute hydrochloric acid, wash twice with ethanol-water (volume ratio 6:4), centrifuge, and dry in an oven.

[0029] (3) Weigh 9.7g of the product obtained in step (2) and 0.3g of poloxamer, add it to the ethanol water (volume ratio 6:1) solution, stir at 45°C for 0.5h, spray dry, and sterilize to obtain starch / Poloxamer co...

Embodiment 3

[0031] (1) Weigh 64g of potato starch and 1.2g of sodium trimetaphosphate, add them into 100ml of sodium hydroxide solution with a pH of 9, and react at 50°C for 3h. After the reaction, wash with water until neutral, dehydrate with 95% ethanol, centrifuge, and dry in an oven.

[0032] (2) Weigh 20g of the product obtained in step (1), 3.2g of sodium hydroxide, add 32ml of water to dissolve, add 192ml of ethanol, mix well, and react at 40°C for 1h. Then add sodium chloroacetate ethanol water (sodium chloroacetate: ethanol: water = 1 g: 10 ml: 10 ml) solution 80 ml. The temperature was raised to 40°C for 5h. After the reaction, adjust to neutral with dilute hydrochloric acid, wash twice with ethanol-water (volume ratio 6:4), centrifuge, and dry in an oven.

[0033] (3) Weigh 9.7g of the product obtained in step (2) and 0.3g of poloxamer, add it to the ethanol-water (volume ratio 6:1) solution, stir at 35°C for 2h, spray dry, and sterilize to obtain starch / Poloxamer complex h...

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to a starch / poloxamer composite styptic powder and a preparation method thereof. Crosslinking, alkalification and etherification are carried out on the raw material pure natural plant starch to prepare carboxymethyl modified starch, and the carboxymethyl modified starch is compounded with poloxamer to obtain the starch / poloxamer composite styptic powder. The preparation method comprises the following steps: (1) carrying out crosslinking reaction on natural plant starch and a crosslinking agent in a sodium hydroxide solution with the pH value of 9-14; (2) sequentially carrying out reaction on the starch treated by the step (1) with sodium hydroxide and sodium monochloroacetate; and (3) stirring the starch treated by the step (2) and poloxamer in an ethanol water solution, and drying. The styptic powder can keep better cohesiveness after absorbing blood so as to enhance the styptic effect, and can be degraded and absorbed by the human body or directly cleaned with normal saline or pure water without leaving residues or injuring the wound surface. Besides, the technique has high operability and favorable market prospects.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a starch / poloxamer composite hemostatic powder and a preparation method thereof. Background technique [0002] In general surgery or trauma, there will be bloody wounds. Whether the bleeding can be stopped quickly, safely and effectively has become an important factor in the successful treatment of patients. At present, there are many kinds of hemostatic powder products on the market, and the materials are various, and the common ones are chitosan, gelatin, collagen, and starch. However, these products have more or less problems: animal-derived raw materials, slow degradation, susceptibility to infection, expensive and so on. [0003] Starch is derived from plants and has good biocompatibility. It can be degraded by amylase in the body and absorbed by the human body. The modified starch not only retains the original characteristics of the starch, but also improves ...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/42A61L15/44A61L15/64
Inventor 王瑛纪晨旭王绪帅刘娜朱连连
Owner 山东奥能医疗科技有限公司
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