Starch/poloxamer composite styptic powder and preparation method thereof

Abstract

The invention belongs to the technical field of medicine, and particularly relates to a starch / poloxamer composite styptic powder and a preparation method thereof. Crosslinking, alkalification and etherification are carried out on the raw material pure natural plant starch to prepare carboxymethyl modified starch, and the carboxymethyl modified starch is compounded with poloxamer to obtain the starch / poloxamer composite styptic powder. The preparation method comprises the following steps: (1) carrying out crosslinking reaction on natural plant starch and a crosslinking agent in a sodium hydroxide solution with the pH value of 9-14; (2) sequentially carrying out reaction on the starch treated by the step (1) with sodium hydroxide and sodium monochloroacetate; and (3) stirring the starch treated by the step (2) and poloxamer in an ethanol water solution, and drying. The styptic powder can keep better cohesiveness after absorbing blood so as to enhance the styptic effect, and can be degraded and absorbed by the human body or directly cleaned with normal saline or pure water without leaving residues or injuring the wound surface. Besides, the technique has high operability and favorable market prospects.

Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a starch / poloxamer composite hemostatic powder and a preparation method thereof. Background technique

[0002] In general surgery or trauma, there will be bloody wounds. Whether the bleeding can be stopped quickly, safely and effectively has become an important factor in the successful treatment of patients. At present, there are many kinds of hemostatic powder products on the market, and the materials are various, and the common ones are chitosan, gelatin, collagen, and starch. However, these products have more or less problems: animal-derived raw materials, slow degradation, susceptibility to infection, expensive and so on.

[0003] Starch is derived from plants and has good biocompatibility. It can be degraded by amylase in the body and absorbed by the human body. The modified starch not only retains the original characteristics of the starch, but also improves ...