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Method for low-cost industrialized preparation of recoverable degradable calcium phosphate bone fracture plate

A technology of calcium phosphate and bone plate, which is applied in medical science, surgery, etc., to achieve the effects of easy industrial production, low cost, recyclability and simplification

Inactive Publication Date: 2017-01-11
北京交泰科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The main purpose of the present invention is to overcome the defects of the existing bone plate material preparation methods, and provide a new industrial preparation method for the preparation of whisker-reinforced calcium phosphate bone plate. The technical problem to be solved is to use efficient recycling process The preparation of low-cost calcium phosphate raw materials, and the method of preparing whisker-reinforced bone plate materials through high-efficiency microwave sintering technology, improve the foundation for the preparation of one-time degradable calcium phosphate bone plate

Method used

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  • Method for low-cost industrialized preparation of recoverable degradable calcium phosphate bone fracture plate

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Ammonium chloride and calcium carbonate are heated and reacted to generate CO2, ammonia gas, and calcium chloride. Add phosphoric acid to the above calcium chloride solution with a ratio of calcium to phosphorus of 3 / 2, and pass through the above CO2, ammonia gas, stir for 3 hours to form nano powder, filter and dry at 100 degrees, calcined at 900 degrees for later use, the filtrate chlorine Ammonium chloride recovery.

[0031] Repeat the above steps again, and add CTAB 1mol% weight ratio before passing the gas, and react the mixed solution for 10 hours to obtain whiskers after settling and filtering to obtain whiskers. The above calcium phosphate and whiskers are mixed at a ratio of 5 / 1, mixed evenly by ball milling for 1 hour, dry-pressed at 30 MPa to form a bone plate, and sintered in a microwave oven at 1100 degrees for 10 minutes to obtain nano-calcium phosphate ceramics. The bone plate was made after drilling to form threads. Finally, the used bone plate was clea...

Embodiment 2

[0033] Ammonium chloride and calcium carbonate are heated and reacted to generate CO2, ammonia gas, and calcium chloride. Add phosphoric acid to the above calcium chloride solution with a ratio of calcium to phosphorus of 3 / 2, and pass through the above CO2, ammonia gas, stir for 3 hours to form nano powder, filter and dry at 100 degrees, calcined at 900 degrees for later use, the filtrate chlorine Ammonium chloride recovery.

[0034] Repeat the above steps again, and add 1.5 mol% CTAB by weight before feeding the gas, and react the mixed solution for 10 hours to obtain whiskers after settling and filtering to obtain whiskers. The above calcium phosphate and whiskers are mixed at a ratio of 5 / 1, mixed evenly by ball milling for 1 hour, dry-pressed at 25MPa to form a bone plate, and sintered in a microwave oven at 1100 degrees for 10 minutes to obtain nano-calcium phosphate ceramics. The bone plate was made after drilling to form threads. Finally, the used bone plate was clean...

Embodiment 3

[0036] Ammonium chloride and calcium carbonate are heated and reacted to generate CO2, ammonia gas, and calcium chloride. Add phosphoric acid to the above calcium chloride solution with a ratio of calcium to phosphorus of 3 / 2, and pass through the above CO2, ammonia gas, stir for 3 hours to form nano powder, filter and dry at 100 degrees, calcined at 900 degrees for later use, the filtrate chlorine Ammonium chloride recovery.

[0037] Repeat the above steps again, and add CTAB 2mol% weight ratio before passing the gas, the mixed solution reacts for 10 hours, the whiskers are obtained after sedimentation, and the whiskers are obtained by filtration. The above calcium phosphate and whiskers are mixed at a ratio of 5 / 1, ball milled for 1 hour to mix evenly, dry-pressed at 28MPa to form a bone plate, and sintered in a microwave oven at 1100 degrees for 10 minutes to obtain nano-calcium phosphate ceramics. The bone plate was made after drilling to form threads. Finally, the used b...

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Abstract

The invention relates to a method for low-cost recycling reuse industrialized preparation of a novel degradable bone fracture plate material, wherein the method comprises the steps: carrying out a heating reaction of ammonium chloride and calcium carbonate, to generate CO2, ammonia gas and calcium chloride; adding phosphoric acid into a calcium chloride solution with the calcium-to-phosphorus ratio of 3 to 2, introducing the CO2 and the ammonia gas, stirring for 3 hours to generate a nano powder, filtering, then drying at the temperature of 100 DEG C, calcining at the temperature of 900 DEG C for standby application, and recycling filtrate ammonium chloride; repeating the above steps, adding CTAB with the weight ratio of 1-3 mol% before introducing gas, carrying out a reaction with a calcium mixed solution for 10-24 hours, and filtering to obtain crystal whiskers after obtaining a crystal whisker precipitate; carrying out ball milling of the calcium phosphate and the crystal whiskers with the ratio of 5 to 1 for 1 hour, mixing evenly, carrying out dry-pressing molding at the pressure of 25-30 MPa into a bone fracture plate shape; and sintering for 10 minutes at the temperature of 1100 DEG C with a microwave oven to prepare nano calcium phosphate ceramics, drilling to form a thread, to obtain a bone fracture plate, and finally, cleaning the bone fracture plate after use, soaking in a 0.1 M dilute hydrochloric acid for 24 hours, and recycling, wherein an obtained solution is used for raw material preparation.

Description

technical field [0001] The invention relates to a preparation process in the field of biological materials, in particular to a low-cost industrial preparation method for recyclable and degradable calcium phosphate bone plate. Background technique [0002] Calcium phosphate has a similar chemical composition to human bone and has very good biocompatibility, which is a very promising substitute material for bone repair. Moreover, its degradability enables it to be rapidly degraded to be replaced by new bone after being implanted in the body. With nano-ceramics used in applications. Calcium phosphate nano-whisker-reinforced ceramics can greatly improve the fracture resistance of the matrix through toughening mechanisms such as whisker pinning and cracks. Moreover, the calcium phosphate whiskers match the thermal expansion coefficient of the matrix, and the absence of internal stress contributes to the improvement of fracture resistance. The preparation process of the nano-ce...

Claims

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Application Information

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IPC IPC(8): A61L31/02A61L31/14C04B35/447C04B35/622
Inventor 李锋涛于显著王静
Owner 北京交泰科技有限公司
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