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Woven fully-degradable magnesium alloy airway stent and preparation method thereof

A magnesium alloy, fully degradable technology, applied in stents, medical science, prostheses, etc., can solve the problems of poor support force and resilience, and achieve the effect of improving support force and biocompatibility

Active Publication Date: 2017-02-01
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are reports about magnesium alloys using laser engraving to prepare airway stents. This type of stent is easy to engrave and process, but the supporting force and resilience are poor

Method used

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  • Woven fully-degradable magnesium alloy airway stent and preparation method thereof
  • Woven fully-degradable magnesium alloy airway stent and preparation method thereof
  • Woven fully-degradable magnesium alloy airway stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A braided fully degradable magnesium alloy airway stent, the preparation process is as follows:

[0025] (1) Preparation of Mg-Zn-Y-Nd alloy wire: (a) as-cast Mg-Zn-Y-Nd alloy (for its preparation method, please refer to patent ZL201110043303.8, the same below) and homogenize at 480°C After treatment for 48 hours, an alloy rod with a diameter of 3 mm was prepared by hot extrusion at a temperature of 380 °C, an extrusion ratio of 44, and an extrusion rate of 2 m / min; (b) a traditional drawing device was used at room temperature to The alloy bar is drawn 3 to 4 times, and the single-pass deformation of the drawing is 15%. After the drawing is completed, it is annealed. The annealing temperature is 200 ° C, and the annealing time is 15 minutes; The diameter is 0.28mm wire, the tensile strength of 0.28mm wire is 300MPa, the yield strength is 220MPa, and the elongation is 15% measured by a universal tensile machine; the internal structure of the wire is 1~3µm through a metal...

Embodiment 2

[0030] A braided fully degradable magnesium alloy airway stent, the preparation process is as follows:

[0031] (1) Preparation of Mg-Zn-Y-Nd alloy wire: same as step (1) of Example 1;

[0032] (2) Weaving forming: same as step (2) of embodiment 1;

[0033] (3) Surface treatment: The above-mentioned heat-set magnesium alloy airway bracket was treated for 5 seconds in an electrolytic polishing solution composed of 5v% glycerin, 25v% phosphoric acid and 70v% alcohol, polishing voltage 10V, current 2A , then immerse the polished stent in a coupling agent for coupling treatment, the immersion time is 3min, the coupling agent is 5v% silane KH-570 aqueous solution, after coupling, the stent is dried, and 1v% chitosan The aqueous solution is dip-coated on the inner and outer surfaces of the stent, and the dip-coating is repeated 6 times, each dipping time is 10s, and it is dried. The tensile strength of the stent is 380MPa, the elongation is 35%, and the support force is 5N, measure...

Embodiment 3

[0036] A braided fully degradable magnesium alloy airway stent, the preparation process is as follows:

[0037] (1) Preparation of Mg-Zn-Y-Nd-Zr alloy wire: (a) cast Mg-Zn-Y-Nd-Zr alloy (for its preparation method, refer to patent ZL201310418031.4, the same below) at 460°C Homogenization treatment was carried out under the condition of hot extrusion method to prepare alloy rods with a diameter of 3mm, the extrusion temperature was 400°C, the extrusion ratio was 44, and the extrusion speed was 2m / min; (b) the traditional drawing method was used at room temperature The drawing device draws the alloy bar 3~4 times, the single-pass deformation of the drawing is 15%, and annealing treatment is carried out after the drawing is completed, the annealing temperature is 250°C, and the annealing time is 10min; (c) repeat the step (b ) until it is made into a wire with a diameter of 0.24mm. The tensile strength is 330MPa, the yield strength is 250MPa, and the elongation is 18%. The inter...

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Abstract

The invention discloses a woven fully-degradable magnesium alloy airway stent and a preparation method thereof. The magnesium alloy airway stent is integrally formed by weaving a magnesium alloy wire with the diameter of 0.1-0.5 mm; meshes in the surface of the magnesium alloy airway stent are quadrilateral; the area of a single mesh is 2-10 mm<2>; one-wire, two-wire or more-wire magnesium alloy wire with the diameter of 0.1-0.5 mm is woven. The fully-degradable magnesium alloy airway stent provided by the invention can improve the supporting force and the biocompatibility of the airway stent, achieve full degradation of the airway stent and overcome defects of the conventional stent. Therefore, the woven fully-degradable magnesium alloy airway stent is expected to be widely applied to an airway.

Description

technical field [0001] The invention belongs to the field of mechanical processing and molding, and in particular relates to a braided fully degradable magnesium alloy airway support and a preparation method thereof. Background technique [0002] Airway stents have become an essential and common device for solving airway stenosis. Tracheal and bronchial stenosis caused by various benign and malignant lesions can theoretically be treated by placing airway stents, which not only improves the quality of life of patients but also provides time for further treatment of the primary disease. [0003] At present, the clinically used stents are mainly nickel-titanium alloy stents, which have strong supporting force and good plasticity. Since the placement of the stent is temporary in most cases, with the treatment of the primary lesion, the stenosis of the airway will be alleviated, and the stent will become loose and displaced, so the stent needs to be recovered. When the Nitinol ...

Claims

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Application Information

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IPC IPC(8): A61F2/90A61F2/958C25F3/18C22F1/06
CPCA61F2/90A61F2/958A61F2210/00A61F2240/002A61F2250/0067A61F2250/0081C22F1/06C25F3/18
Inventor 关绍康刘耿王利国朱世杰韩新巍李宗明任克伟孙兵王剑锋王莉颖杨永欣
Owner ZHENGZHOU UNIV
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