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Pharmaceutical composition of transdermal plaster for treating diarrhea and transdermal plaster

A technology of transdermal patches and compositions, applied in the field of pharmaceutical compositions, which can solve the problems of inconspicuous curative effects, and achieve the effects of safe medication, convenient use, and obvious effects

Inactive Publication Date: 2017-02-08
邓蜀俐
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the active ingredients of transdermal patches for treating respiratory diseases on the market are mainly traditional Chinese medicine or Chinese medicine extracts, and there is a defect that the curative effect is not obvious

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Chen Moumou, female, 1 year and 6 months old, had diarrhea repeatedly for half a month, and the stool was in the shape of egg flower, and she had diarrhea 6-8 times a day, with a lot of volume.

[0073] Suxiao Zhixie Capsules, 0.6mg;

[0074] 654-2, 20 mg;

[0075] Muxiang Shunqi pills, 600mg;

[0076] Montmorillonite, 3g, mixed evenly, then mixed with an adhesive, placed in the center of Artemisia annua seed cake, adhesive plaster placed on the pharmaceutical composition, that is transdermal patch, Artemisia artemisia seed cake facing the skin of human body, put the transdermal patch The agent is pasted on the navel of the human body. After 24 hours, the number of stools decreased to 3-4 times a day, which was slightly dry. After 48 hours, the dressing was changed, and the stool was normal after 2 patches (4 days later).

Embodiment 2

[0078] Hou Moumou, male, 9 months old, had repeated diarrhea for 4 days, mucus, pus and blood in stools, 7-8 times a day, and the amount was small; routine stool examination: red blood cells: +, white blood cells: ++, phagocytes: visible under a high-power microscope 2- 4; diagnosed as acute bacillary dysentery.

[0079] Take berberine hydrochloride, 240mg;

[0080] Amikacin Hydrochloride 100mg

[0081] 654-2, 10 mg;

[0082] Muxiang Shunqi pills, 480mg;

[0083] Montmorillonite, 3g, mixed evenly, then mixed with an adhesive, placed in the center of Artemisia annua seed cake, adhesive plaster placed on the pharmaceutical composition, that is transdermal patch, Artemisia artemisia seed cake facing the skin of human body, put the transdermal patch The agent is pasted on the navel of the human body. After 24 hours, the stool improved, and the abdominal pain was relieved after 2 hours after the medicine was applied. After 48 hours, the dressing was changed, and the stool was ...

Embodiment 3

[0085] Zhang Moumou, female, 2 and a half years old, had repeated diarrhea for 3 days, watery, 5-6 times a day, and the amount was large; the diagnosis was acute gastroenteritis.

[0086] Diphenoxylate, 5mg;

[0087] 654-2, 10 mg;

[0088] Muxiang Shunqi pills, 480mg;

[0089] Berberine hydrochloride, 30mg;

[0090] Montmorillonite, 3g is mixed evenly, then mixed with an adhesive, placed in the center of Artemisia annua seed cake, and the adhesive plaster is placed on the pharmaceutical composition, which is a transdermal patch. Attached to the navel of the human body. After 24 hours, the stool became significantly dry and the frequency decreased. After 48 hours, the dressing was changed, and after 2 patches (after 4 days), the stool was normal, and the diarrhea stopped.

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PUM

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Abstract

The invention discloses a pharmaceutical composition of a transdermal plaster for treating diarrhea and the transdermal plaster. The pharmaceutical composition comprises the following components in parts by mass: 5-20mg of 654-2, 480-900mg of qi-regulating pill of aucklandia and 240-480mg of berberine hydrochloride; or 10-40mg of 654-2, 600-1200mg of qi-regulating pill of aucklandia and 4-12mg of diphenoxylate; or 10-40mg of 654-2, 600-1200mg of qi-regulating pill of aucklandia and 4-8mg of loperamide hydrochloride. The pharmaceutical composition disclosed by the invention can be used for treating bacterial diarrhea, virus diarrhea, fungal diarrhea, indigestion diarrhea and other multiple diarrhea diseases, is applicable to a patient who is sick for more than 1 month, is safe to take and convenient to use, achieves an obvious effect after 24 hours, and realizes healing after 3-5 days.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions, and in particular relates to a pharmaceutical composition and a transdermal patch for treating diarrhea. Background technique [0002] Diarrhea is the passing of more than three loose or watery stools per day, or more frequent bowel movements than an individual's normal frequency. Diarrhea is often a symptom of a gastrointestinal infection and can be caused by a variety of bacteria, viruses and parasites. The disease is often accompanied by abdominal distension, abdominal pain, dehydration and electrolyte imbalance, which is extremely harmful to human health and is a worldwide public health problem. Diarrheal disease is the second leading cause of death in children under 5 years of age, with 1.5 million children dying from it each year. [0003] Common diarrhea mainly includes bacterial diarrhea, viral diarrhea, fungal diarrhea and dyspepsia diarrhea. [0004] The method for treating...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/70A61K47/46A61P1/12A61P31/04A61P31/12A61P31/10A61P1/14A61K31/4196A61K31/4375A61K31/451A61K31/7036A61K31/7048A61K33/06
CPCA61K36/285A61K9/0002A61K9/7038A61K31/4196A61K31/4375A61K31/451A61K31/7036A61K31/7048A61K33/06A61K36/284A61K36/484A61K36/575A61K36/752A61K36/889A61K36/8905A61K36/9064A61K36/9068A61K47/46A61K2300/00
Inventor 邓蜀俐
Owner 邓蜀俐
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