Liquid crystal nanoparticle precursor particles, self-assembled liquid crystal nanoparticles and preparation method thereof

Abstract

The invention relates to a liquid crystal nanoparticle precursor microparticle, a self-assembled liquid crystal nanoparticle and preparation methods thereof. The preparation method of the liquid crystal nanoparticle precursor microparticle comprises dissolving an agent in a solvent, adding a molten liquid crystal material and a diluent into the solution, uniformly mixing the solution and drying the solution. The liquid crystal nanoparticle precursor microparticle comprises 0.5-20wt% of the agent and a ratio of the liquid crystal material, the diluent to the solvent is 1: 1-7: 40-150. The liquid crystal nanoparticle precursor particles and water undergo a hydration reaction so that the liquid crystal nanoparticle precursor particles are cracked and self-assembled to form the self-assembled liquid crystal nanoparticles. The liquid crystal nanoparticles are processed to form the liquid crystal nanoparticle precursor precursor microparticle solids so that formation of an unstable liquid crystal nanoparticle dispersed solution is avoided and the traditional method problems of leakage of liquid crystal nanoparticle agents, low encapsulation efficiency and dispersion system instability are solved.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a self-assembled liquid crystal nanoparticle precursor particle and a preparation method thereof. Background technique [0002] Most pharmaceutically active compounds face the problem of low solubility. Research shows that 40% of marketed drugs and 70% of drugs under research are poorly soluble drugs. The slow dissolution rate and low dissolution degree of poorly soluble drugs lead to low bioavailability of the drug and can not achieve ideal clinical efficacy. The drug must be delivered to the treatment site at a certain speed and reach a therapeutic concentration in order to exert its curative effect in time. This process requires the use of pharmaceutical preparations to increase the dissolution rate and solubility of the drug, thereby increasing the bioavailability of the drug and improving the clinical efficacy. The rate and extent of drug dissolution and release f...

AI Technical Summary

Problems solved by technology

[0009] Based on this, the present invention provides a kind of preparation method of liquid crystal nanoparticle precursor particle, in the process of preparation avoiding the dispersion solution of unstable liquid crystal nanoparticle, the prepared liquid crystal nanoparticle precursor particle is prepared and stored The stability is good during the process, and it can self-assemble to form in-situ liquid crystal nanoparticles after contact with water, which solves the problems of liquid crystal nanoparticles prepared by traditional methods such as drug leakage, low encapsulation efficiency, and unstable dispersion system.

Images