Laser veining method for improving surface cell adhesion of medical implants

An implant and adhesion technology, which is applied in the field of material surface processing, can solve problems such as incompletely clear influence mechanisms, and achieve the effects of increasing production efficiency, improving cell adhesion performance, and fast processing speed

Active Publication Date: 2017-02-15
BEIHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The microscopic morphology of the surface of medical materials, polymers and other materials has been proven to affect the growth of cells on the surface. The specific mechanism of the influence is not completely clear, but experiments have confirmed that: compared with the flat surface, the uneven microstructure of the surface It can affect the orientation, growth shape, coverage, etc. of certain cells when they grow on the surface of the material

Method used

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  • Laser veining method for improving surface cell adhesion of medical implants
  • Laser veining method for improving surface cell adhesion of medical implants
  • Laser veining method for improving surface cell adhesion of medical implants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1): Take a TC4 titanium alloy sheet with a thickness of 2 mm, clean it in absolute alcohol, and clean it again after mechanical grinding and polishing.

[0033] (2): Put the sample in such as figure 2 On the workbench of the picosecond laser processing system shown (using a fiber laser with a wavelength of 1060nm and a pulse width of 300ps), set the laser power to 15W, the frequency to 500KHz, the scanning speed to 200mm / s, and the scanning line spacing to 40μm. The size of the area is 15mm×15mm, the number of scanning repetitions is 5 times, and the laser processing system is started to start processing.

[0034] (3): Remove the processed titanium alloy block from the workbench and wipe it with absolute alcohol.

Embodiment 2

[0036] (1): Take a 2mm thick 316L stainless steel sheet, wash it in anhydrous alcohol, mechanically polish it and wash it again.

[0037] (2): Put the sample in such as figure 2 On the workbench of the picosecond laser processing system shown (using a fiber laser with a wavelength of 1060nm and a pulse width of 300ps), set the laser power to 20W, the frequency to 100KHz, the scanning speed to 3000mm / s, and the scanning line spacing to 70μm. The size of the area is 15mm×15mm, the number of scanning repetitions is 5 times, and the laser processing system is started to start processing.

[0038] (3): Remove the processed titanium alloy block from the workbench and wipe it with absolute alcohol.

Embodiment 3

[0040] (1): Take a Ni-Ti alloy sheet with a thickness of 2 mm, clean it in absolute alcohol, and clean it again after laser polishing.

[0041] (2): Put the sample in such as figure 2 On the working table of the shown nanosecond laser processing system (Nd:YAG laser with a wavelength of 532nm and a pulse width of 34ns), the laser power is set to 30W, the frequency is 10KHz, the scanning speed is 500mm / s, and the scanning line spacing is 100μm. Set the size of the scanning area to 15mm×15mm, the number of scanning repetitions to 5 times, and start the laser processing system to start processing.

[0042] (3): Repeat step 2 after transposing the sample by 90 degrees.

[0043] (4): Remove the processed alloy sheet from the workbench and wipe it with absolute alcohol.

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Abstract

The invention discloses a laser veining method for improving the surface cell adhesion of medical implants. The method comprises the steps that (1) the surface of a medical material is subjected to chemical cleaning and deoiling, and mechanical grinding and polishing or laser polishing in sequence, and then the surface is cleaned again; (2) the medical material cleaned in the step (1) is placed on a workbench of a laser processing system, laser parameters are set, the laser processing system is started, laser rays scan the surface of the medical material surface at a certain speed through galvanometer scanning, and finally a veined surface is obtained through laser ablation, specifically, the processing process is carried out under inert gas shielding; and (3) the processed medical material is cleaned. The method can be widely applied to the medical implants of specific applications, enables the surfaces of the implants to obtain better cell adhesion performance, and improves the medical effects of the implants.

Description

technical field [0001] The invention relates to a laser texturing method for improving cell adhesion on the surface of medical implants. The method can be widely applied to special-purpose medical implants, so that the surface of the implants can obtain better cell adhesion performance and improve the medical effect of the implants, and belongs to the technical field of material surface processing. Background technique [0002] Due to its ultra-high peak power density, ultra-fast time resolution and high focusing ability, short-pulse laser technology has been widely used in many fields such as medicine, microelectronics, micro / nano processing and material science. Short-pulse laser micro / nano processing technology, with its remarkable advantages of extremely high processing resolution, extremely small heat-affected zone and high processing quality, gradually replaces traditional processing technology and becomes the most effective method for micro / nano processing of solid ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B23K26/362B23K26/60B23K26/70
CPCB23K26/361B23K26/60B23K26/70
Inventor 管迎春马程鹏周伟
Owner BEIHANG UNIV
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