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Preparation method of pre-activated polystyrene microspheres

A technology of polystyrene microspheres and preactivation, which is applied in the field of polymer chemistry, can solve the problems of limited production, restraint, and difficult control of activation efficiency, and achieve good stability

Inactive Publication Date: 2017-02-15
杨明志
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In this process, the activation efficiency is not easy to control; the dispersion process generally uses methods such as ultrasound, press filtration, ultrafiltration, etc., but they are all subject to the capacity of the equipment, and the production capacity of each batch is limited.

Method used

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Embodiment Construction

[0015] The present invention will be further described below in conjunction with specific embodiment:

[0016] Preparation of polystyrene microspheres:

[0017] Styrene needs to be pretreated, and the polymerization inhibitor is removed before use; Styrene is first washed with NaOH solution with a mass concentration of about 10%, standing for stratification, and retaining the organic layer. After repeating three times, wash with a large amount of deionized water Near neutrality, and then after vacuum distillation for later use.

[0018] Add polyvinylpyrrolidone PVP into 30% ethanol aqueous solution, after stirring to form a homogeneous system, pass N 2 Evacuate the oxygen in the container, and slowly add the styrene that is dissolved in azobisisobutyronitrile dropwise under stirring at a rate of 300rpm. After the dropwise addition, keep N 2 Atmosphere and a rate of 300rpm, polymerize at 70°C for 10h, centrifuge the reaction solution, discard the supernatant, wash the lower l...

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Abstract

The invention discloses a preparation method of pre-activated polystyrene microspheres. Styrene is used as a monomer, polyvinylpyrrolidone is used as a dispersion stabilizer, 30% ethanol aqueous solution is used as a dispersing medium and azodiisobutyronitrile is used as an initiator to prepare the polystyrene microspheres by adopting a dispersion-polymerization process; then the polystyrene microspheres are added to a microsphere pre-activation solution prepared from ethanesulfonic acid, carbodiimide and N-methyl succinic imide to prepare pre-activated polystyrene microspheres. The pre-activated polystyrene microspheres prepared by the preparation method are small in particle diameter, suitable for binding with antibodies, or antigens and other proteins and good in stability, the surfaces of the microspheres are activated, and the microspheres have adsorption or chemical adhesive connecting capability, can be bound with the antibodies, or antigens and other proteins without activation treatment before usage and is suitable for mass production.

Description

technical field [0001] The invention relates to the field of polymer chemistry, in particular to a preparation method of preactivated polystyrene microspheres. Background technique [0002] Surface-functionalized polymer microspheres are easy to react with enzymes, proteins, nucleic acids, etc. due to the presence of active groups such as carboxyl, amino, or hydroxyl groups on the surface, making them widely used in biology, chemistry, materials, and medicine. At present, the preparation of monodisperse functionalized polymer microspheres with controllable particle size has become a research hotspot in the field of polymer materials. Polymer microspheres have the characteristics of large specific surface area, strong adhesion, strong agglutination and strong surface reaction ability, and have broad application prospects. Polymer microspheres with uniform micron-sized particles, as functional polymer materials, have a wide range of applications in analytical chemistry, bioch...

Claims

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Application Information

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IPC IPC(8): C08J7/12C08J7/00C08F112/08C08L25/06
CPCC08J7/12C08F112/08C08J7/00C08J2325/06
Inventor 杨明志
Owner 杨明志
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