Detection and evaluation of miRNA markers for strength training effects or combinations thereof and applications thereof

An endurance training, mir-208b technology, applied in the field of miRNA markers or their combination, can solve the problems of sample preservation, intra-assay and inter-assay variation, lack of muscle damage, poor repeatability, etc., to save cost and time, and avoid complicated Detection, easy-to-detect effects
CN106399473BActive Publication Date: 2019-12-06NANJING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING UNIV
Publication Date
2019-12-06

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Abstract

The invention discloses miRNA markers for detecting and evaluating effect of strength training or a combination thereof and use thereof. The miRNA markers or the combination of the miRNA markers comprise / comprises miR-208b, MiR-532, miR-133a, miR-133b, miR-206, miR-21, miR-181a and miR-221, and the combination can be used for detection and / or forecast of the effect of muscle endurance training, muscle hypertrophy training and muscle biggest strength training. Plasma is relative easy to obtain, no other tissue is needed, the detection belongs to non-invasive examination, plasma miRNA can reflect whole body system-wide suffered mechanical, hormonal and metabolic stress during the strength training, the plasma miRNA as an assistant detection index can improve the accuracy level of the detection, can reflect the physiological status of the whole process of the strength training at the molecular level, and provides a new index for the detection of the effect of the strength training and design of strength training programs.
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Description

Technical field

[0001] The invention belongs to the field of biotechnology, and relates to miRNA markers or combinations thereof for detecting and evaluating strength training effects and applications thereof. Background technique

[0002] The quality and function of skeletal muscle play a key role in preventing diseases (such as type 2 diabetes, cardiovascular disease, muscle atrophy, etc.), improving the quality of life, and improving athletic ability (1-4). Strength exercise is the most effective way to improve and maintain the quality and function of skeletal muscles. In the past 30 years, the popularity rate of strength training has increased rapidly. In daily exercise practice, different kinematic parameters (strength training) can be selected according to different purposes (improving skeletal muscle endurance, increasing skeletal muscle hypertrophy, and enhancing muscle maximum strength). Methods, training intensity and amount, choice of exercise methods and sequence, re...

Claims

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