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Compound type nano-structure Raman-enhanced substrate, preparation method and application

A nanostructure and composite technology, applied in Raman scattering, measuring devices, instruments, etc., can solve the problems of SERS quantitative application limitations, and achieve low production cost, simple process and operation steps, and mild reaction and detection conditions. Effect

Active Publication Date: 2017-02-15
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the complexity of the nanostructure, there are great differences in the signals collected in different regions of the substrate, sometimes reaching several orders of magnitude. These technical limitations limit the quantitative application of SERS.

Method used

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  • Compound type nano-structure Raman-enhanced substrate, preparation method and application
  • Compound type nano-structure Raman-enhanced substrate, preparation method and application
  • Compound type nano-structure Raman-enhanced substrate, preparation method and application

Examples

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Effect test

Embodiment 1

[0030] 1. Preparation and transfer of Au monolayer film

[0031] In this embodiment, according to the device and method provided by the Chinese invention patent CN103590037B, a gold nanoparticle monolayer film is first prepared at the gas-liquid interface of the gold sol containing gold nanoparticles, and then the gold nanoparticle monolayer film is transferred to the On a solid phase substrate, the specific steps are as follows:

[0032] (1) Preparation of Au nanoparticle film: add 100 mL (0.25 mmol dm -3 ) chloroauric acid solution, heated to boiling, add 2 mL (0.01 g·mL -1 ) sodium citrate solution, keep boiling for 15 min to obtain 15 nm gold sol. Take 25 mL of the sol, add 1 mL (0.01 g·mL) sodium citrate solution, 1 mL (0.01 g·mL) PVP solution and 20 mL (2.5 mmol·dm -3 ) Hydroxylamine hydrochloride solution; use a syringe pump to inject 1 mL·min under stirring -1 dropwise at a rate of 2.5 mmol·dm -3 ) in 20 mL of chloroauric acid solution to obtain 50 nm gold sol. T...

Embodiment 2

[0047] 1. Preparation and transfer of Au monolayer film

[0048] (1) Preparation of Au nanoparticle film: add 100 mL (0.25 mmol dm -3 ) chloroauric acid solution, heated to boiling, add 2 mL (0.01 g·mL -1 ) sodium citrate solution, keep boiling for 15 min to obtain 15 nm gold sol. Take 25 mL of the sol, add 1 mL (0.01 g·mL) sodium citrate solution, 1 mL (0.01 g·mL) PVP solution and 20 mL (2.5 mmol·dm -3 ) Hydroxylamine hydrochloride solution; use a syringe pump to inject 1 mL·min under stirring -1 dropwise at a rate of 2.5 mmol·dm -3 ) in 20 mL of chloroauric acid solution to obtain 50 nm gold sol. The sol was placed at 40 °C for 10 h, and a dense and bright gold nanoparticle monolayer film floating on the air-liquid interface could be observed.

[0049] (2) Transfer of the Au nanoparticle film: A 0.4 cm×0.4 cm clean silicon wafer is inserted vertically into the gas-liquid interface, and then slowly pulled vertically to attach the Au nanoparticle monolayer film to the sur...

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Abstract

The invention discloses a compound type nano-structure Raman-enhanced substrate, a preparation method and application. The preparation method comprises the following steps: carrying out film formation of Au nano-particles and transferring to prepare an Au film-1,4-benzene dithioglycol-Au film sandwich structure by using 1,4-benzene dithioglycol as an internal standard substance, then evaporating a molybdenum trioxide layer with a thickness for isolating direct contact of inner layer metal and a detected molecule so as to prevent competitive adsorption between the internal standard molecule and the detected molecule, and thus obtaining the compound type nano-structure Raman-enhanced substrate. The compound type substrate prepared in the invention can obtain the characteristic spectrum signal of the internal standard molecule and the characteristic spectrum signal of the detected molecule at the same time, a relation between SERS relative signal strength and concentration logarithm of the detected molecule is established in a certain concentration range by using the relation strength relation between the characteristic peak of the internal standard molecule and the characteristic peak of the detected molecule, analytical means capable of expanding an SERS technology into quantitative determination is provided, and the compound type nano-structure Raman-enhanced substrate is significant in scientific research and practical application.

Description

technical field [0001] The invention relates to a multi-layer composite nanostructure Raman enhanced substrate, a preparation method and its application to the quantitative detection of 1,4-benzenedimethyl mercaptan, malachite green, etc., belonging to the preparation and detection application technology of nanostructure substrates field. Background technique [0002] In 1974, Fleischmann of the University of Southampton in the United Kingdom roughened the silver electrode by the electrochemical redox method, and obtained a high-quality Raman spectrum of pyridine molecules adsorbed on the surface of the rough silver electrode. After detailed experimental and theoretical studies by Van Duyne and Creighton et al., this phenomenon was defined as the Surface Enhanced Raman scattering (Surface enhanced Raman scattering, SERS) effect. Since the phenomenon was discovered more than 40 years ago, with the progress of nanotechnology, laser technology, detection technology, instrument...

Claims

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Application Information

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IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 徐敏敏林洁茹姚建林
Owner SUZHOU UNIV
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