Preparation method of total flavonoids in psoralea corylifolia and new medical application of total flavonoids in psoralea corylifolia

A technology of psoralen and total flavonoids, which can be applied in the direction of medical formulas, medical preparations containing active ingredients, drug combinations, etc., and can solve problems such as unsuitable for long-term application
CN106420904AInactive Publication Date: 2017-02-22PEKING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
PEKING UNIV
Publication Date
2017-02-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for preparing total flavonoids from traditional Chinese medicine psoralea corylifolia and a new application of the total flavonoids in psoralea corylifolia to preparation of drugs for preventing or treating the AD (alzheimer's disease). According to different polarities of main ingredients contained in the psoralea corylifolia, low-polarity monoterpene phenols with toxic and side effects are removed through petroleum ether degreasing, flavonoids are extracted with ethyl acetate, the total flavonoids in the psoralea corylifolia are obtained through impurity removal and refinement with activated carbon, and the purity can reach 50% or higher. The method is economical, efficient and suitable for industrial production. In-vitro activity research confirms that the main flavonoids contained in the psoralea corylifolia have different degrees of inhibition activity for multiple related targets of the AD; animal experiments prove that the total flavonoids in psoralea corylifolia can remarkably improve neurodegeneration memory loss symptoms of AD model mice through oral medication, have no toxic and side effects after long-term medication and can be used for preparing drugs for preventing or treating the AD.
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Description

technical field

[0001] The invention relates to a preparation method of total plant flavonoids and its new medical application in the field of preventing or treating Alzheimer's disease. Background technique

[0002] Alzheimer's Disease (AD), also known as senile dementia, is a neurodegenerative disease with frequent occurrence in the elderly. The incidence rate is about 5% among the elderly over 65 years old, and the incidence rate gradually increases with age. The incidence rate reaches 30-40% in the elderly population over 85 years old. Patients suffering from this disease are due to the progressive death and loss of memory-related neurons, which leads to progressive decline in memory and cognitive ability. Generally, it takes about 8-10 years since the onset to develop severe dementia, often accompanied by bedsores, fractures, Pneumonia, malnutrition and other secondary physical diseases or organ failure lead to death. Due to the complex pathogenic mechanism of the dis...

Claims

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