Method for preparing alternate lamellar bio-degraded polymer drug controlled-release composite

Abstract

The invention provides a method for preparing an alternate lamellar bio-degraded polymer drug controlled-release composite. The method mainly includes the steps that polymer-based drug quick release layers and polymer-based drug slow release layers with different release behaviors are alternately and orderly arranged in a melt co-extrusion mode, polymers deform and are oriented in the extrusion process through the shear and stretching effects of a layer multiplier during multiple times of lamellar overlapping, drug diffusion and release channels are improved, and the obtained alternate lamellar bio-degraded polymer drug controlled release composite has the reasonable initial release concentration and required long-term release rate and achieves controllable, flexible and effective release of drugs to meet different drug release requirements. The alternate lamellar bio-degraded polymer drug controlled release composite is controllable in form and adjustable in formula; the mechanical property is excellent; continuous volume production can be achieved, and the production efficiency can be improved; the application range is wide, and wide industrial and market prospects are achieved.

Description

technical field [0001] The invention relates to the preparation of an alternate layered biodegradable polymer drug slow-release material with configurable structure, designable performance, continuous production and flexible and controllable drug release behavior, which belongs to the field of functional composite material preparation. Background technique [0002] Compared with traditional drug delivery systems, drug sustained-release preparations do not require frequent drug administration, can maintain effective drug concentrations in the body for a long time, reduce the pain and inconvenience caused by frequent drug use, and can greatly improve drug efficacy and reduce toxic side effect. Polymer drug sustained-release materials are generally divided into two categories: non-biodegradable materials and biodegradable materials. Among them, biodegradable polymer materials do not require secondary surgery due to their good biocompatibility and non-toxicity, and metabolites h...

AI Technical Summary

Problems solved by technology

There are many deficiencies in these traditional homogeneous sustained-release preparations: the drug release of some preparation methods is nonlinear; the preparation form is relatively single, and it is difficult to flexibly and effectively control the dosage and administration plan, which increases the difficulty of compound administration; some preparations have poor stability, low efficacy

[0005] Although the above studies can overcome the problems of the traditional homogeneous drug-loading materials, such as the difficulty in flexible and effective control of the drug dosage and drug regimen, but due to the multi-use solution method for preparation, there are difficulties in solvent removal, and there are relatively large limitations in the choice of matrix and drugs. , The process is complex, it is difficult to meet the needs of industrial mass production

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