Extraction technology of wall-broken ganoderma lucidum spore powder polysaccharide

A technology of broken-wall Ganoderma lucidum spore powder and extraction process, which can be used in medical preparations containing active ingredients, organic active ingredients, pharmaceutical formulations, etc., and can solve the problems of harsh optimal operating conditions, low extraction efficiency, and large solvent consumption. , to achieve the effect of retaining biological activity, high condition requirements, and low condition requirements

Inactive Publication Date: 2017-02-22
NANJING XIYUAN BIOPHARML SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The traditional extraction and separation methods of Ganoderma lucidum polysaccharides generally have disadvantages such as low extraction efficiency, low purity, and large amount of solvents.
Although new extraction and separation technologies such as ultrasonic extraction, enzymatic extraction, and macroporous resin separation can make up for the shortcomings of traditional methods to a certain extent, due to the harsh optimal operating conditions of the above methods, if they are to be applied to actual production , a large amount of basic experimental research is still needed

Method used

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  • Extraction technology of wall-broken ganoderma lucidum spore powder polysaccharide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation of broken ganoderma lucidum spore powder:

[0031] (1) Raw material preparation: take the ganoderma lucidum spore powder raw material, wash with water, and remove impurities;

[0032] (2) Vacuum drying: set the vacuum degree and vacuum drying time, the vacuum degree is 0.9MPa, the vacuum drying time is 6h, so that the moisture after vacuum drying is ≤6%;

[0033] (3) Freeze embrittlement and wall breaking: place the vacuum-dried raw materials at -18°C for embrittlement for 4 hours; then at 55°C, carry out ultrasonic mixing to break the wall. The time is 8 minutes, the mixing speed is 35 rpm, and the broken ganoderma spore powder is obtained.

[0034] The extraction process of the broken ganoderma lucidum spore powder polysaccharide comprises the following steps:

[0035] 1) Pretreatment: Take 70kg of broken Ganoderma lucidum spore powder, add purified water and mix in a mixer to obtain a mixture; the speed of the mixer is 30rpm, the mixing temperature is 5...

Embodiment 2

[0042] Preparation of broken ganoderma lucidum spore powder:

[0043] (1) Raw material preparation: take the ganoderma lucidum spore powder raw material, wash with water, and remove impurities;

[0044] (2) Vacuum drying: set the vacuum degree and vacuum drying time, the vacuum degree is 0.9MPa, the vacuum drying time is 6h, so that the moisture after vacuum drying is ≤6%;

[0045] (3) Freeze embrittlement and wall breaking: place the vacuum-dried raw materials at -18°C for embrittlement for 4 hours; then at 55°C, carry out ultrasonic mixing to break the wall. The time is 8 minutes, the mixing speed is 35 rpm, and the broken ganoderma spore powder is obtained.

[0046] The extraction process of the broken ganoderma lucidum spore powder polysaccharide comprises the following steps:

[0047] 1) Pretreatment: Take 70kg of broken Ganoderma lucidum spore powder, add purified water and mix in a mixer to obtain a mixture; the speed of the mixer is 40rpm, the mixing temperature is 60°...

Embodiment 3

[0054] Preparation of broken ganoderma lucidum spore powder:

[0055] (1) Raw material preparation: take the ganoderma lucidum spore powder raw material, wash with water, and remove impurities;

[0056] (2) Vacuum drying: set the vacuum degree and vacuum drying time, the vacuum degree is 0.9MPa, the vacuum drying time is 6h, so that the moisture after vacuum drying is ≤6%;

[0057] (3) Freeze embrittlement and wall breaking: place the vacuum-dried raw materials at -18°C for embrittlement for 4 hours; then at 55°C, carry out ultrasonic mixing to break the wall. The time is 8 minutes, the mixing speed is 35 rpm, and the broken ganoderma spore powder is obtained.

[0058] The extraction process of the broken ganoderma lucidum spore powder polysaccharide comprises the following steps:

[0059] 1) Pretreatment: take 70kg of broken Ganoderma lucidum spore powder, add purified water and mix in a mixer to obtain a mixture; the speed of the mixer is 35rpm, the mixing temperature is 5...

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Abstract

The invention discloses an extraction technology of wall-broken ganoderma lucidum spore powder polysaccharide. The extraction technology comprises the following steps of 1 pretreating; 2 ultrasonic cavitating; 3 primary purifying; 4 extract concentrating; 5 freeze-drying; 6 pulverizing and collecting, wherein freeze-dried powder is pulverized uniformly through a pulverizer, particles are screened with a 70-90-mesh screen and then bagged, and bags are sealed. According to the technology, the technological processes are all conducted under the condition of low temperature and the condition of not making contact with chemical solvent, the biological activity of the wall-broken ganoderma lucidum spore powder polysaccharide is effectively retained, and therefore the wall-broken ganoderma lucidum spore powder polysaccharide is prevented from being influenced by physical and chemical factors such as the solvent and the temperature. The ganoderma lucidum spore powder polysaccharide extracted through the technology is mellow and fragrant in mouthfeel, does not have the bitter taste of ganoderma lucidum mycelium polysaccharide and ganoderma lucidum fruiting body polysaccharide and has the sweet and mellow taste of sucrose, a flavor covering agent does not need to be added in a follow-up finished product formula, and the ganoderma lucidum spore powder polysaccharide can be directly added into the formula; the polysaccharide material has the good fluidity and compressibility and the high stacking density and is suitable for being processed into tablets and capsules.

Description

technical field [0001] The invention relates to a process for extracting polysaccharide from wall-broken ganoderma lucidum spore powder, which belongs to the technical field of pharmaceutical preparations. Background technique [0002] Ganoderma lucidum polysaccharide is the active ingredient of Ganoderma lucidum "strengthening the body and strengthening the foundation". Ganoderma lucidum polysaccharide exists in the mycelium of Ganoderma lucidum, fruiting body, spore powder and the fermentation broth of engineering strains of Ganoderma lucidum, and is a mixture composed of peptidoglycan, dextran, and heteropolysaccharides. Most of the glucans are β2 glucans, a few are α2 glucans, and β2 glucans are the main components of its activity. Studies have shown that Ganoderma lucidum polysaccharides have a wide range of physiological activities, such as improving the body's immunity, inhibiting tumors, enhancing the body's ability to withstand hypoxia, eliminating free radicals, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715
CPCA61K31/715C08B37/0003C08B37/006
Inventor 刘勇业
Owner NANJING XIYUAN BIOPHARML SCI & TECH
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